Thrombolysis With Fibrinolysin in Cerebral Arterial Occlusion; the Role of Angiography

Sussman, Bernard J.; Fitch, Thomas S.P.

doi:10.1177/000331975901000413

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Thrombolytic Therapy1

Clinical Pharmacology and Therapeutics1

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1960

2021

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Cited by 16 publications

(2 citation statements)

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“…Already small series of patients treated with fibrinolysin have been reported (Sussman and Fitch, 1959;Herndon, Meyer, Johnson and Landers, I960;Clarke and Cliffton, I960) but results are inconclusive. It would seem probable that commercial preparation and standardization of thrombolytic agents of the types used in these studies, and also the methods of therapeutic control are as yet at a stage when clinical evaluation is premature.…”

Section: Thrombolytic Therapymentioning

confidence: 99%

The Diagnosis and Treatment of Cerebrovascular Disease

Shaw

1961

Postgraduate Medical Journal

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Section: Thrombolytic Therapymentioning

confidence: 99%

The Diagnosis and Treatment of Cerebrovascular Disease

Shaw

1961

Postgraduate Medical Journal

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“…Recently apreparation of human fibrinolysin'i> has become commercially available, and clinical experiences with it recorded. [145][146][147][148][149][150][151][152][153][154][155] Since details of its biochemical characterization have not been published and the potency of the material is expressed in undefined fibrinolytic units, we have analyzed sampIes in our laboratory. Each vial of astated potency of 50,000 fibrinolytic units contain 5.1 casein units of plasmin and 6,500 Christensen units of streptokinase.…”

Section: Clinical Pharmacology and Therapeuticsmentioning

confidence: 99%

Proteolytic enzymes: a therapeutic evaluation

Sherry

Fleteher

1960

Clin Pharma and Therapeutics

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A promising development 0/ recent years has been the application of proteolytic enzymes to the therapy of disease in the human. Originally applied directly to the diseased area to efJect a local enzymatic debridement, proteolytic enzyme therapy is now being extended on a systemic basis to widen considerably the scope of its applicability. This report summarizes the current state of knowledge of proteolytic enzymes as therapeutic agents. It indicates those areas where the usefulness of proteolytic enzyme therapy is well established and those areas where the efficacy of such enzyme therapy is less well accepted or under active clinical investigation. Though much has been accomplished already at the clinicallevel, particular stress is placed on the problems which remain to be solved if proper exploitation of this new and exciting area of pharmacology is to be achieved.

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