Thromboinflammatory response in SARS-CoV-2 sepsis

Maiese, Aniello; Passaro, G; Matteis, Alessandra De; Fazio, V.; Raffaele, La Russa; Paolo, Marco Di

doi:10.1177/0025817220926915

Cited by 26 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, patients with ARDS related to COVID-19 had a median static compliance of the respiratory system 28% higher (n = 297; 41 mL/cm H 2 O [IQR [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]) in those with no COVID-19 ARDS related (n = 960; 32 mL/cm H 2 O [25], p < 0.0001). Moreover, they found that most of the patients had markedly increased D-dimer concentrations (median 1880 ng/mL [IQR 820-6243]).…”

Section: ↑D-dimermentioning

confidence: 81%

“…Laboratory findings in COVID-19 (see Table 2) are: prothrombin time (PT) and activated partial thromboplastin time (aPTT) normal or slightly prolonged, platelet counts normal or increased, fibrinogen increased, D-dimer increased, factor VIII activity increased, von Willebrand factor (VWF) antigen greatly increased, minor changes in natural anticoagulants (i.e., slight decreases in antithrombin and mild increase in protein C) [33][34][35][36].…”

Section: Coagulation Abnormalities In Patients With Covid-19mentioning

confidence: 99%

See 1 more Smart Citation

Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection

Zanza

Racca

Longhitano

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease. Bilateral pneumonia, acute respiratory failure, systemic inflammation, endothelial dysfunction and coagulation activation are key features of severe COVID-19. Fibrinogen and D-dimer levels are typically increased. The risk for venous thromboembolism is markedly increased, especially in patients in the intensive care unit despite prophylactic dose anticoagulation. Pulmonary microvascular thrombosis has also been described and the risk for arterial thrombotic diseases also appears to be increased while bleeding is less common than thrombosis, but it can occur. Evaluation for venous thromboembolism may be challenging because symptoms of pulmonary embolism overlap with COVID-19, and imaging studies may not be feasible in all cases. The threshold for evaluation or diagnosis of thromboembolism should be low given the high frequency of these events. Management and treatment are new challenges due to the paucity of high-quality evidence regarding efficacy and safety of different approaches to prevent or treat thromboembolic complications of the disease. All inpatients should receive thromboprophylaxis unless contraindicated. Some institutional protocols provide more aggressive anticoagulation with intermediate or even therapeutic dose anticoagulation for COVID-19 patients admitted to ICU. Therapeutic dose anticoagulation is always appropriate to treat deep venous thrombosis or pulmonary embolism, unless contraindicated. This article reviews evaluation and management of coagulation abnormalities in individuals with COVID-19.

show abstract

Section: ↑D-dimermentioning

confidence: 81%

Section: Coagulation Abnormalities In Patients With Covid-19mentioning

confidence: 99%

Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection

Zanza

Racca

Longhitano

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been reported that inflammatory mechanisms and immune system play a role in this involvement [9,30]. Cytokine storm syndrome with immune system irregularities is thought to exacerbate interstitial pneumonia resulting in diffuse alveolar damage and cause viral sepsis with hypercoagulability, thus creating a vicious cycle [31].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 autopsies of Istanbul

Arslan¹,

Büyük²,

Ziyade³

et al. 2021

Ir J Med Sci

View full text Add to dashboard Cite

Background/aims The aim of this study is to share autopsy findings of COVID-19-positive cases and autopsy algorithms for safely handling of suspicious bodies during this pandemic. Methods COVID-19-positive cases of Istanbul Morgue Department were retrospectively analyzed. Sampling indications for PCR tests in suspicious deaths, macroscopic and microscopic findings obtained in cases with positive PCR tests were evaluated. Results In the morgue department, 345(25.8%) of overall 1336 autopsy cases were tested for COVID-19. PCR test was found positive in 26 cases. Limited autopsy procedure was performed in 7 cases, while the cause of death was determined by external examination in the remaining 19 cases. Male-to-female ratio was found 3.3:1 and mean age was 60.0 ± 13.6 among all PCR-positive cases. Cause of death was determined as viral pneumonia in fully autopsied cases. Most common findings were sticky gelatinous fluid in cavities and firm and swollen lungs, varying degrees of consolidation. In microscopy, diffuse alveolar epithelial damage, type-II pneumocyte hyperplasia, hyaline membrane formation, fibrinous exudate, and fibrinous plaques in the alveoli were the most common findings. Conclusions In COVID-19 autopsies, pulmonary findings were found to be prominent and the main pathology was pneumonia. Older age and findings of chronic diseases indicate that the cases were in the multirisk group in terms of COVID-19 mortality.

show abstract

“…SARS-CoV-2 infection causes the release of a significant amount of pro-inflammatory cytokines that aggravate interstitial pneumonia and acute respiratory distress syndrome (ARDS) [3][4][5][6]. This clinical picture evolves into viral sepsis with prominent hypercoagulability and multiorgan dysfunction [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Autopsy findings in COVID-19-related deaths: a literature review

Maiese

Manetti

Russa

et al. 2020

Forensic Sci Med Pathol

Self Cite

181

172

View full text Add to dashboard Cite

Although many clinical reports have been published, little is known about the pathological post-mortem findings from people who have died of the novel coronavirus disease. The need for postmortem information is urgent to improve patient management of mild and severe illness, and treatment strategies. The present systematic review was carried out according to the Preferred Reporting Items for Systematic Review (PRISMA) standards. A systematic literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from database inception to June 2020 was performed. We found 28 scientific papers; the total amount of cases is 341. The major histological feature in the lung is diffuse alveolar damage with hyaline membrane formation, alongside microthrombi in small pulmonary vessels. It appears that there is a high incidence of deep vein thrombosis and pulmonary embolism among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed. A uniform COVID-19 post-mortem diagnostic protocol has not yet been developed. In a time in which international collaboration is essential, standardized diagnostic criteria are fundamental requirements.

show abstract

Thromboinflammatory response in SARS-CoV-2 sepsis

Cited by 26 publications

References 10 publications

Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection

Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection

COVID-19 autopsies of Istanbul

Autopsy findings in COVID-19-related deaths: a literature review

Contact Info

Product

Resources

About