Thromboembolism and Oral Contraceptivers: An Epidemiologic Case-Control Study12

Sartwell, Philip E.; Masi, Alfonse T.; Arthes, Federico G.; Greene, Gerald R.; Smith, Helen

doi:10.1093/oxfordjournals.aje.a121082

Cited by 333 publications

(87 citation statements)

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“…The present investigation examined a subgroup of middle-class white women aged [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] In the regression analysis for fasting triglycerides (table 3), the significant variables were current smoking (p = 0.001) and current OC use (p = 0.007), the mean triglyceride levels for OC users being approximately 19 mg/100 ml higher than for nonusers. Total plasma cholesterol has been shown to be a strong predictor of coronary risk, especially at younger ages.…”

Section: Subjects and Methods Study Populationmentioning

confidence: 99%

Oral contraceptive use and fasting triglyceride, plasma cholesterol and HDL cholesterol.

Hennekens¹,

Da²,

Castelli³

et al. 1979

Circulation

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SUMMARY Fasting plasma triglyceride, plasma cholesterol and high-density lipoprotein (HDL) cholesterol levels were studied for 190 white women, ages 21-39 years, who were classified according to their oral contraceptive (OC) usage patterns at two community surveys, 3 years apart. The mean level of fasting triglyceride was higher among current OC users (95 mg/100 ml) than among nonusers (73 mg/100 ml) (p = 0.002). After adjustment for the possible confounding effects of age, weight, current cigarette smoking and fasting glucose level, current OC users still had a mean plasma triglyceride level 19 mg/100 ml higher than that of nonusers (p = 0.007). Current OC users also appeared to have somewhat higher levels of total cholesterol which were of borderline significance in crude and adjusted analyses. Methods of ProcedureDuring each community survey, questionnaire information was obtained concerning cigarette smoking (yes or no), age, and stated body weight. In the clinic, fasting blood specimens were drawn by antecubital venipuncture with the women sitting. The specimens were collected between 8 and 10 a.m. in tubes that contained sodium EDTA. The tubes were inverted eight times and centrifuged, and the plasma was decanted. In addition, a fasting blood glucose was collected in a tube containing fluoride-oxalate, and measured by the glucose oxidase method.8Triglycerides were measured by a modification of the Kessler-Lederer method.9 Cholesterol concentrations in the total plasma were measured by the method of Abell-Kendall." HDL cholesterol fractions were separated by precipitating the other lipoproteins with heparin-manganese chloride, and measured by a modification of the method of Burstein and colleagues.1' These determinations were performed in the laboratory of the Framingham Heart Study, which participates in a quality-control program through a cooperative arrangement with the Lipid Research Clinics. 12 486

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Section: Subjects and Methods Study Populationmentioning

confidence: 99%

Oral contraceptive use and fasting triglyceride, plasma cholesterol and HDL cholesterol.

Hennekens¹,

Da²,

Castelli³

et al. 1979

Circulation

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“…Among the 1396 controls, eight refused to participate, were mentally retarded, or lived abroad; 18 returned an uncompleted questionnaire; 17 had had thromboembolic disease previously; 31 50 ,ug oestrogen were associated with an odds ratio for cerebral thromboembolic attack of 2*9 (95% confidence interval 1-6 to 5 4), those containing 30-40 ,ug oestrogen an odds ratio of [1][2][3][4][5][6][7][8] (1.1 to 2.9), those containing progestogen only an odds ratio of 0 9 (0*4 to 2.4). The odds ratio did not change with increasing age or with duration oforal contraceptive use.…”

mentioning

confidence: 99%

Oral contraception and risk of a cerebral thromboembolic attack: results of a case-control study.

Lidegaard

1993

BMJ

195

103

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“…4 Fifty of the 60 cases had had thrombophlebitis of the lower extremities subsequent to the inciting event, three had had thrombophlebitis and a pulmonary embolus, and another three had had a pulmonary embolus alone. One case had had thrombophlebitis and a cerebrovascular accident, another a myocardial infarction, another a popliteal artery thrombosis, and one an axillary vein thrombosis.…”

Section: Methodsmentioning

confidence: 99%

Oral contraceptive use in patients with thromboembolism following surgery, trauma, or infection.

Greene¹,

Sartwell²

1972

Am J Public Health

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Thromboembolism and Oral Contraceptivers: An Epidemiologic Case-Control Study12

Cited by 333 publications

References 0 publications

Oral contraceptive use and fasting triglyceride, plasma cholesterol and HDL cholesterol.

Oral contraceptive use and fasting triglyceride, plasma cholesterol and HDL cholesterol.

Oral contraception and risk of a cerebral thromboembolic attack: results of a case-control study.

Oral contraceptive use in patients with thromboembolism following surgery, trauma, or infection.

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