Thromboembolism and Air Travel

O'Donnell, Dan; Bounameaux, Henri

doi:10.1016/s0140-6736(88)92446-4

Cited by 6 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using an a priori agreed definition of prolonged travelling, the prevalence of recent travelling in the total cohort in the present study was approximately 7%, which was the same in subjects both with and without venous thromboembolism. This figure is in agreement with that found in earlier reports (15,16), although Eklof et al and Ferrari et al observed a higher prevalence of recent travel in patients with venous thromboembolism. It should be noted however that their patients were admitted to a hospital in Hawaii (an island to which flying is the main means of transportation) and in Nice (close to the second busiest airport in France and in an area very popular for tourists), respectively (12,17).…”

Section: Discussionsupporting

confidence: 93%

“…Why are our findings at odds with earlier reports? Almost all previous studies reported on cases with venous thrombosis, in which details about travelling were obtained later (11)(12)(13)(14)(15)(16). Others have used substitute outcome measures, such as asymptomatic thrombi of which the relevance in this population is unknown (30).…”

Section: Discussionmentioning

confidence: 99%

“…Although the literature provides theoretical arguments for the assumption that long distance travel may be a risk factor for venous thromboembolism, the true risk is poorly estimated. It has been described that 5-25% of patients with documented thrombosis had a history of recent prolonged travelling (11)(12)(13)(14)(15)(16). However, these figures were usually based on non-or inappropriately controlled studies and often retrospective analyses.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Travel and the risk of symptomatic venous thromboembolism

Wolde¹,

Kraaijenhagen²,

Schiereck³

et al. 2003

Thromb Haemost

View full text Add to dashboard Cite

SummaryWhether long-distance travel and symptomatic venous thromboembolism (VTE) are associated is debated. On the basis of the available literature a fair risk estimate cannot be obtained. We estimated an accurate odds ratio for the relationship between recent travelling and symptomatic VTE.From three case-control studies consisting of 788 and 170 patients with clinically suspected deep vein thrombosis (DVT) and 989 patients with clinically suspected pulmonary embolism (PE) referred for diagnostic work-up, a pooled odds ratio for the relation between travel and symptomatic VTE was calculated. Cases were patients in whom the diagnosis was confirmed according to a diagnostic management strategy, whereas controls were patients in whom the diagnosis was excluded and who had an uneventful clinical follow-up. Patients were seen in the period April 1997 to September 2000. Travel history was recorded prior to diagnostic work-up.The pooled odds ratio for the association between any travel and symptomatic venous thromboembolism was 0.9 (95% CI: 0.6-1.4). The median travel time was 7 h (quartile range 4 to 10 h). Separate analyses performed for different types of transport (plane, car, bus or train) yielded comparable odds ratios. The analysis for duration of travelling showed an increased odds ratio of 2.5 (95% CI: 1.0-6.2) in the category of 10-15 h of travelling.This study shows that the average traveller does not have an increased risk for symptomatic venous thromboembolism. Only very long travelling (more than 10 h) may be associated with venous thromboembolic disease.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Travel and the risk of symptomatic venous thromboembolism

Wolde¹,

Kraaijenhagen²,

Schiereck³

et al. 2003

Thromb Haemost

View full text Add to dashboard Cite

show abstract

“…Compression of the popliteal vessels on the edge of the seat promotes venous stasis. 15 The decrease in atmospheric humidity, which increases imperceptible losses, 20 insufficient intake of liquids, as well as the diuretic effect that is brought on by drinking alcohol, all bring about a certain degree of dehydration with the consequent hemoconcentration, 1,11,15,16,19,[20][21][22][23][24] as proven by Simons and Krol. 20 Plasma and urine osmolarity increases in healthy subjects after 8 hours of simulated flight.…”

Section: Commentmentioning

confidence: 99%