Thromboembolic Complications of Pregnancy

Bolan, Jean C.

doi:10.1097/00003081-198312000-00014

Cited by 24 publications

(8 citation statements)

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“…Maternal complications may be related to underlying disease (e.g., the 20-fold increased risk of maternal mortality/serious morbidity associated with early gestational hypertension and proteinuria), direct complications of the obstetric problem (e.g., chorioamnionitis associated with preterm prelabour rupture of membranes), or treatment (e.g., thromboembolism associated with bed rest prescribed for fetal growth restriction). 2,3 To date, severe maternal morbidity associated with very preterm delivery has not been adequately studied.…”

Section: Introductionmentioning

confidence: 99%

The Canadian Perinatal Network: A National Network Focused on Threatened Preterm Birth at 22 to 28 Weeks’ Gestation

Magee

Dadelszen

Allen

et al. 2011

Journal of Obstetrics and Gynaecology Canada

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OBSTETRICS AbstractObjective: The Canadian Perinatal Network (CPN) maintains an ongoing national database focused on threatened very preterm birth . The objective of the network is to facilitate between-hospital comparisons and other research that will lead to reductions in the burden of illness associated with very preterm birth .Methods: Women were included in the database if they were admitted to a participating tertiary perinatal unit at 22+0 to 28+6 weeks' gestation with one or more conditions most commonly responsible for very preterm birth, including spontaneous preterm labour with contractions, incompetent cervix, prolapsing membranes, preterm prelabour rupture of membranes, gestational hypertension, intrauterine growth restriction, or antepartum hemorrhage . Data were collected by review of maternal and infant charts, entered directly into standardized electronic data forms and uploaded to the CPN via a secure network .Results: Between 2005 and 2009, the CPN enrolled 2524 women from 14 hospitals including those with preterm labour and contractions (27 .4%), short cervix without contractions (16 .3%), prolapsing membranes (9 .4%), antepartum hemorrhage (26 .1%), and preterm prelabour rupture of membranes (23 .0%) . The mean gestational age at enrolment was 25 .9 ± 1 .9 weeks and the mean gestation age at delivery was 29 .9 ± 5 .1 weeks; 57 .0% delivered at < 29 weeks and 75 .4% at < 34 weeks . RésuméObjectif : Le Réseau périnatal canadien (RPC) tient une base de données nationale continue centrée sur l'accouchement très prématuré appréhendé . L'objectif du réseau est de faciliter les comparaisons interhôpitaux et la tenue d'autres recherches qui mèneront à des réductions du fardeau de la maladie associé à l'accouchement très prématuré .Méthodes : Les femmes étaient incluses à la base de données lorsqu'elles étaient admises dans une unité périnatale tertiaire participante entre 22+0 et 28+6 semaines de gestation en raison de la présence d'un ou de plusieurs des états pathologiques les plus couramment à l'origine de l'accouchement très prématuré (dont le travail préterme spontané s'accompagnant de contractions, la béance du col utérin, le prolapsus des membranes, la rupture prématurée des membranes préterme, l'hypertension gestationnelle, le retard de croissance intra-utérin ou l'hémorragie antepartum) . Les données ont été recueillies au moyen de l'analyse des dossiers maternels et infantiles, saisies directement dans des formulaires de données électroniques standardisés et téléchargées dans le RPC par l'intermédiaire d'un réseau sécurisé . Résultats :Entre 2005 et 2009, le RPC a sollicité la participation de 2 524 femmes issues de 14 hôpitaux, y compris celles qui présentaient un travail préterme s'accompagnant de contractions (27,4 %), un col court sans contractions (16,3 %), un prolapsus des membranes (9,4 %), une hémorragie antepartum (26,1 %) et la rupture prématurée des membranes préterme (23,0 %) . L'âge gestationnel moyen au moment de l'admission à l'étude était de 25,9 ± 1,9 semaines et l'âge ge...

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Section: Introductionmentioning

confidence: 99%

The Canadian Perinatal Network: A National Network Focused on Threatened Preterm Birth at 22 to 28 Weeks’ Gestation

Magee

Dadelszen

Allen

et al. 2011

Journal of Obstetrics and Gynaecology Canada

View full text Add to dashboard Cite

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“…Pulmonary embolism follows ectopic pregnancy as the second leading cause of maternal mortality with a death rate of 0.1 1 to 0.7 for every 10,000 deliveries [30]. Thromboembolic complications have been estimated to occur in 2 to 5 of every 1,000 deliveries [30,31]. The increased frequency of thromboembolic disease associated with pregnancy has been attributed to an increase in clotting factors VII, VIII, and X, as well as to an increased fibrinogen level and decreased fibrinolytic activity [31].…”

Section: Causes Of Acute Respiratory Failurementioning

confidence: 99%

“…Thromboembolic complications have been estimated to occur in 2 to 5 of every 1,000 deliveries [30,31]. The increased frequency of thromboembolic disease associated with pregnancy has been attributed to an increase in clotting factors VII, VIII, and X, as well as to an increased fibrinogen level and decreased fibrinolytic activity [31]. Depression in antithrombin III activity may also have a role, if one can extrapolate from data on estrogen therapy [32].…”

Section: Causes Of Acute Respiratory Failurementioning

confidence: 99%

“…Several authors have reviewed the appropriate diagnostic steps and treatment of venous thrombosis and pulmonary embolism in general [33] and during pregnancy and the puerperium [30,31]; this review will therefore focus on the diagnosis and management of massive pulmonary embolism associated with severe respiratory and hemodynamic compromise. Respiratory failure in pulmonary embolism may be caused by extensive occlusion of the vasculature or by concomitant pulmonary edema.…”

Section: Causes Of Acute Respiratory Failurementioning

confidence: 99%

“…The typical symptoms and signs of betaadrenergic tocolytic-induced pulmonary edema are chest discomfort, dyspnea, tachypnea (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) breaths/min), rales, and pulmonary edema on chest roentgenogram. Evidence of pulmonary edema develops relatively acutely, within 30 to 72 hours into beta-adrenergic tocolytic therapy.…”

Section: Causes Of Acute Respiratory Failurementioning

confidence: 99%

See 2 more Smart Citations

Acute Respiratory Failure in Pregnancy

Hollingsworth¹,

Pratter²,

Irwin³

1989

J Intensive Care Med

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Acute respiratory failure in pregnancy has multiple etiologies, including thromboembolism, amniotic fluid embolism, venous air embolism, aspiration of gastric contents, respiratory infections, asthma, beta-adrenergic tocolytic therapy, and pneumomediastinum and pneu mothorax. Proper management of acute respiratory fail ure in pregnancy requires an understanding of the specific diseases and the normal gestational changes that occur in maternal respiration (decreased functional re sidual capacity, increased minute ventilation, mild respi ratory alkalosis) and hemodynamics (increased cardiac output, increased blood and plasma volume, unchanged central pressures). Knowledge of the determinants of oxygen delivery to fetal tissue (uterine blood flow, pla cental transfer, fetal circulation) and how they are af fected by changes in maternal hemodynamics, position, acid-base status, and medications can help sustain nor mal fetal development, whenever possible, without compromising maternal care. Diagnostic testing such as radiography, hemodynamic monitoring, and fetal moni toring are considered in terms of attendant risk to the mother or the fetus, alterations in normal values related to gestation, and indications for usage. Similarly, the risks and benefits of supportive and specific therapies for the various etiologies of acute respiratory therapy are reviewed.

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Ambulatory Management of Thromboembolic Disease During Pregnancy With Continuous Infusion of Heparin

Brabeck¹

1987

JAMA

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Thromboembolic Complications of Pregnancy

Cited by 24 publications

References 0 publications

The Canadian Perinatal Network: A National Network Focused on Threatened Preterm Birth at 22 to 28 Weeks’ Gestation

The Canadian Perinatal Network: A National Network Focused on Threatened Preterm Birth at 22 to 28 Weeks’ Gestation

Acute Respiratory Failure in Pregnancy

Ambulatory Management of Thromboembolic Disease During Pregnancy With Continuous Infusion of Heparin

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