Thromboelastography for the Prevention  of Perioperative Venous Thromboembolism  in Orthopedics

Fan, De-Jing; Ouyang, Ziyao; Ying, Yanping; Huang, Shuangxia; Tao, Pinyue; Pan, Xiao‐Ben; Lu, Shuyu; Pan, Qi-Ni

doi:10.1177/10760296221077975

Cited by 13 publications

(5 citation statements)

References 54 publications

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“…CK MA has previously been used as the primary TEG outcome parameter for CVD risk assessment [28][29][30][31][32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

“…Thrombelastography (TEG) is widely used to monitor and direct haemostatic treatment and captures the different aspects of haemostasis from clot initiation to clot lysis [28]. In recent years, it has been demonstrated that TEG can detect prothrombotic haemostatic alterations in populations with high CVD risk compared to controls and may be a useful tool for predicting CVD risk [28][29][30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

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The effect of Mycobacterium tuberculosis treatment on thrombelastography-assessed haemostasis: a prospective cohort study

Lorentsson,

Clausen,

Faurholt-Jepsen

et al. 2024

Thrombosis J

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Background and objective Tuberculosis disease (TB) and tuberculosis infection (TBI) have been associated with increased risk of cardiovascular disease which may be connected to infection-related haemostatic changes. It is unknown if treatment of Mycobacterium tuberculosis influences haemostasis. Here, we assessed if TB or TBI treatment affects thrombelastography (TEG)-assessed haemostasis. Methods Individuals with TB or TBI were included from a TB outpatient clinic in Copenhagen, Denmark. Patients treated with antithrombotic medication or systemic immunosuppressants were excluded. TEG analysis was performed before and after TB/TBI treatment using the TEG®6s analyser to provide data on the reaction time of clot initiation (R) (min), the speed of clot formation (K) (min) and clot build-up (Angle) (°), maximum clot strength (MA) (mm), and clot breakdown/fibrinolysis (LY30) (%). Differences in TEG were assessed using paired t tests. Results We included eleven individuals with TB with median [interquartile range] [IQR] age 52 (Liu et al. in Medicine (United States) 95, 2016) years and mean (standard deviation) (SD) body mass index (BMI) 24.7 (6.3) kg/m2 as well as 15 individuals with TBI with median [IQR] age 49 (Wells et al. in Am J Respir Crit Care Med 204:583, 2021) years and BMI 26.0 (3.2) kg/m2. Treatment reduced MA for both TB (64.0 (6.3) vs. 57.9 (5.2) mm, p = 0.016) and TBI (61.3 (4.1) vs. 58.6 (5.0) mm, p = 0.023) whereas R, K, Angle and LY30 were unaffected. Conclusion TEG analysis showed that treatments of TB and TBI were associated with reduced MA which may indicate the existence of cardiovascular benefits from therapy. Trial registration Registered at ClinicalTrials.gov 05 April 2021 with registration number NCT04830462.

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“…CK MA has previously been used as the primary TEG outcome parameter for CVD risk assessment [28][29][30][31][32][33][34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of Mycobacterium tuberculosis treatment on thrombelastography-assessed haemostasis: a prospective cohort study

Lorentsson,

Clausen,

Faurholt-Jepsen

et al. 2024

Thrombosis J

View full text Add to dashboard Cite

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“…LY30 and LY60 represent the strength of blood clotting at 30 and 60 min after the beginning of fibrinolysis, respectively, reflecting the speed of clot dissolution ( 62 ), despite the no clear variation between LY30 and LY60 in our study. An increase in these values indicates hyperfibrinolysis, while a decrease indicates a weakened fibrinolysis ( 63 ). As discussed above, the controlling and/or regulatory factors of blood hypercoagulability are complex, and our current research found statistical correlations between them.…”

Section: Discussionmentioning

confidence: 99%

Thromboelastogram and coagulation function index: relevance for female breast cancer

Peng,

Zhu,

Ren

2024

Front. Oncol.

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IntroductionScreening and postoperative intervention of breast tumors are critical for the effective diagnosis and treatment of disease development, and reliable diagnostic/screening methods become a key link. ObjectiveThromboelastogram (TEG), routine platelet (PLT) count, and the coagulation function indicators in patients with different breast diseases were determined and analyzed to explore their predictive value in secondary bleeding disorders.MethodsA total of 131 patients with breast diseases, admitted to Jiangsu University Affiliated Hospital from January 2019 to December 2022, were selected as the research subjects. The detection items were analyzed using the receiver operating curve (ROC) after grouping for secondary bleeding disorders of patients with breast cancer.ResultsThe reaction (R) and the coagulation (K) times were lower in the malignant breast disease group, while the coagulation angle (α), maximum amplitude (MA), coagulation index (CI), fibrinogen (FIB), and D-dimer (D-D) were higher than those in the benign breast disease group. The t-tests proved that the MA and FIB values were statistically significant (p < 0.05) in the benign and malignant breast disease groups. The R and K in patients with breast diseases were positively correlated with the activated partial thromboplastin time (aPTT) and D-D, but were negatively correlated with PLT. The α angle was negatively correlated with aPTT and D-D, but was positively correlated with PLT. The MA for PLT function was positively correlated with FIB and PLT. CI was negatively correlated with aPTT, thrombin time (TT), and D-D, but was positively correlated with PLT. ROC curve analysis showed that the CI and α angle had a significant predictive value, whereas the correlation of the other indicators was relatively low.ConclusionCoagulation tests showed significant differences in patients with breast cancer, differing from those with benign breast diseases. TEG combined with conventional coagulation indicators is potentially valuable for the prediction of secondary bleeding disorders in patients with breast cancer.

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“…In addition, the coagulation function, especially changes in D-dimer levels, were monitored. These factors were beneficial in determining whether a patient would be at high risk of VTE, and whether intervention would help prevent the development of VTE [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Padua prediction score-guided use of low-molecular-weight heparin calcium treatment for the prevention of venous thromboembolism in elderly patients with intracerebral hemorrhage: a clinical observation

2023

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This study used the Padua Prediction Score (PPS) to guide low-molecular-weight heparin calcium (LMWHC) treatment for the prevention of venous thromboembolism (VTE) in elderly patients with intracerebral hemorrhage (ICH). This study retrospectively analyzed 225 elderly patients who were admitted to the intensive care unit (ICU) between June 2016 and June 2022. Patients were divided into control (n = 124) and study (n = 101) groups. Control patients received routine prevention and treatment of VTE, while patients in the study group received PPS-guided LMWHC treatment for the prevention of VTE. Multiple analytical parameters were assessed including thromboelastography indices, coagulation function parameters, venous blood flow velocity, and the incidence of VTE and recurrent ICH. Thromboelastography indices, coagulation function parameters, and the venous blood flow velocity did not differ significantly between the control and study groups (p > 0.05) before intervention and treatment. However, following PPS-guided LMWHC treatment, a significant improvement in these parameters was observed in the study group compared to the control group (p < 0.05). Furthermore, the incidence of VTE was significantly lower in the study group (5.6%) than the control group (14.5%; p = 0.038). No significance differences in the incidence of recurrent ICH were observed (p > 0.05). Our PPS data indicate that LMWHC treatment could significantly improve the coagulation function of elderly patients with ICH, as well as increase the venous blood flow velocity and prevent the occurrence of VTE.

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Thromboelastography for the Prevention of Perioperative Venous Thromboembolism in Orthopedics

Cited by 13 publications

References 54 publications

The effect of Mycobacterium tuberculosis treatment on thrombelastography-assessed haemostasis: a prospective cohort study

The effect of Mycobacterium tuberculosis treatment on thrombelastography-assessed haemostasis: a prospective cohort study

Thromboelastogram and coagulation function index: relevance for female breast cancer

Padua prediction score-guided use of low-molecular-weight heparin calcium treatment for the prevention of venous thromboembolism in elderly patients with intracerebral hemorrhage: a clinical observation

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