Thrombocytosis With Peritoneal Mesothelioma

Jori, Giulio; Turrisi, E; Donnorso, R. Perrone

doi:10.1016/s0140-6736(68)90514-x

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…Other typical symptoms as pre s e n ted in this case a re nausea and vomiting, abdominal enl a r gement, marked weight loss, dys p n e a and ascites fe a t u ring the most common p hysical sign, occurring in 90% of the patients (1). Inte re st i n gly th e re are also rep o rts of an association with th ro m b o c y tosis (18,19) that we also found in our case. Incidenta l finding of malignant mesothelioma during abdominal s u r ge ry has also been described (20).…”

Section: Discussionsupporting

confidence: 86%

Malignant peritoneal mesothelioma with mimicry of pseudomyxoma peritonei in a patient with a history of perforated sigmadiverticulitis

Gölkel¹,

Widjaja²,

Hiller³

et al. 2000

Z Gastroenterol

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We describe a 57-year-old man who presented with diffuse abdominal pain, abdominal enlargement, vomitus, dyspnea and a weight loss of 30 kg within 6 months. These acute symptoms were preceded by an episode of ascites and an acute sigmadiverticulitis 7 months ago. Ultrasonography and computed tomography were suggestive of pseudomyxoma peritonei. However, malignant mesothelioma peritonei was diagnosed by open surgery with biopsy for histological examination. Despite R-2-resection of the tumor and following open hyperthermic intraperitoneal chemotherapy with initial remarkable recovery the patient died 5 months after therapeutical intervention. Malignant peritoneal mesothelioma is an extremely rare tumor with great diagnostic and therapeutic difficulties. We report a case including diagnostical work up and the medical surgical therapy of this disease.

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Section: Discussionsupporting

confidence: 86%

Malignant peritoneal mesothelioma with mimicry of pseudomyxoma peritonei in a patient with a history of perforated sigmadiverticulitis

Gölkel¹,

Widjaja²,

Hiller³

et al. 2000

Z Gastroenterol

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Primary Malignant Peritoneal Mesothelioma

1990

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Mesothelioma of the peritoneum is a rare malignant neoplasm easily mistaken by both surgeon and pathologist for one of the more common neoplasms of the abdomen. Review of our records from metropolitan-area hospitals for the past 15 years identified seven patients with primary peritoneal mesotheliomas. Their diagnosis, management, and survival is analyzed. We report a case of an extended survivor (7 years) and one of a long-term survivor (15 years), as well as what we believe to be the only case in the literature presenting with a coexistent malignant neoplasm. Prevention of this commonly fatal neoplasm is linked to avoiding occupational exposure to asbestos; long-term survival for a few patients may be achieved with correct identification of the neoplasm and aggressive management. This report includes a review of the literature.

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Increased secretion of lnterleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis

Higashihara

Sunaga

Tange

et al. 1992

Cancer

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Background. A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown. Methods. The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, enzyme‐linked immunosorbent assay and immunohistochemical analysis were used. Results. Tumor cells produced large amounts of in‐terleukin‐6 (IL‐6) and small amounts of granulocyte macrophage colony stimulating factor (GM‐CSF) and monocyte colony stimulating factor (M‐CSF). Immunocytochemical staining of tumor cells showed strong positivity for IL‐6. Conclusions. These results indicated that persistant secretion of IL‐6 promoted thrombogenesis in this patient.

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Thrombocytosis With Peritoneal Mesothelioma

Cited by 6 publications

References 2 publications

Malignant peritoneal mesothelioma with mimicry of pseudomyxoma peritonei in a patient with a history of perforated sigmadiverticulitis

Malignant peritoneal mesothelioma with mimicry of pseudomyxoma peritonei in a patient with a history of perforated sigmadiverticulitis

Primary Malignant Peritoneal Mesothelioma

Increased secretion of lnterleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis

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