Thrombocytosis of active rheumatoid disease.

Farr, M.; Scott, D L; Constable, T. J.; Hawker, R J; Hawkins, C F; Stuart, J.

doi:10.1136/ard.42.5.545

Cited by 68 publications

(34 citation statements)

References 20 publications

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“…This is most likely on the basis of anaemia of chronic inflammation, mediated by inflammatory cytokines, in particular interleukin (IL)-6 21 . Similarly, a reactive thrombocytosis associated with active RA is thought to be due to the pro-inflammatory effects of IL-1β and IL-4 22,23 .…”

Section: Discussionmentioning

confidence: 99%

Response to traditional disease-modifying anti-rheumatic drugs in indigent South Africans with early rheumatoid arthritis

et al. 2011

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Objective: To investigate clinical response to traditional disease modifying anti-rheumatic drugs (DMARDs) in indigent South Africans with early RA. Methods: A cohort of patients with early (≤ 2 years) RA who were DMARD-naïve at inception were prospectively assessed for response to DMARDs using the simplified disease activity index (SDAI) over a 12-month period. Patients with low disease activity (LDA) at 12 months were compared to those with moderate and high disease activity with respect to demographic, clinical, autoantibody and radiographic features. Results: The 171 patients (140 females) had a mean (SD) age of 47.1 (12.4) years, symptom duration of 11.7 (7.1) months and baseline SDAI of 39.4 (16.2). There was a significant overall improvement in the

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Section: Discussionmentioning

confidence: 99%

Response to traditional disease-modifying anti-rheumatic drugs in indigent South Africans with early rheumatoid arthritis

et al. 2011

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“…Only the 6.2-kd form of CTAP-Ill was recovered from the extract of normal-appearing synovium from 1 patient with OA. Lanes 2 and 5 in Figure 1 also reveal higher molecular weight isoforms (15)(16) kd) which are recognized by the anti-rCTAP-111 antibody; Tables I and 2). Higher molecular weight isoforms were also detected with patient samples.…”

Section: Detection Of Ctap-111 Isoforms In Extracts Ofmentioning

confidence: 97%

“…Evidence suggesting a link between platelets and articular inflammation includes the association between thrombocytosis and decreased platelet survival time in patients with severe RA (15)(16)(17)(18)(19)(20)(21). Direct evidence indicating significant platelet traffic through inflamed synovial membrane includes detection of extravascular platelets and/or platelet antigens in RA and other inflammatory synovial membranes and joint fluid samples (22)(23)(24)(25)(26).…”

mentioning

confidence: 99%

“…Direct evidence indicating significant platelet traffic through inflamed synovial membrane includes detection of extravascular platelets and/or platelet antigens in RA and other inflammatory synovial membranes and joint fluid samples (22)(23)(24)(25)(26). An important observation was the demonstration that ' "indium-labeled platelets can localize t o inflamed rheumatoid joints (15).…”

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confidence: 99%

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Connective tissue activation. xxxv. detection of connective tissue activating peptide–iii isoforms in synovium from osteoarthritis and rheumatoid arthritis patients: patterns of interaction with other synovial cytokines in cell culture

Castor

Smith

Hossler

et al. 1992

Arthritis & Rheumatism

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Objective. To determine whether extracts of unincubated osteoarthritis (OA) and rheumatoid arthritis (RA) synovial tissue contain connective tissue activating peptide–III (CTAP‐III) isoforms and prostaglandin E2 (PGE2), and whether such extracts have growth‐promoting activity, and to determine whether binary combinations of CTAP‐III with other cytokines reported to be present in synovial tissue lead to synergistic, additive, or inhibitory effects on growth. Methods. Acid–ethanol extracts of human synovium were examined for growth‐promoting activity by measuring formation of 14C‐glycosaminoglycan (14CGAG) and 3H‐DNA in synovial cell cultures; PGE2 was measured by enzyme immunoassay, and CTAP‐III isoforms were identified by Western blotting of extracted proteins separated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis. Growth‐promoting activity of CTAP‐III and other cytokines was tested in synovial cultures treated with the agonists singly and in binary combination, by measuring changes in synthesis of 14C‐GAG and 3H‐DNA. Results. Platelet‐derived CTAP‐III and a cleavage isoform with the electrophoretic mobility of CTAP‐III–des 1–15/neutrophil‐activating peptide–2 (NAP‐2) and PGE2 were found in biologically active extracts of synovial samples from patients with RA and OA. Five growth factors (recombinant epidermal growth factor [rEGF], recombinant interleukin‐1β [rIL‐1β], basic fibroblast growth factor [bFGF], PGE1, and PGE2) in binary combination with CTAP‐III showed synergism in stimulating GAG synthesis; two (recombinant platelet‐derived growth factor type BB [rPDGF‐BB] and recombinant transforming growth factor β [rTGFβ]) had an additive effect. In combination with CTAP‐III, rEGF and rPDGF‐BB had a synergistic effect in promoting DNA synthesis, rTGFβ and rbFGF had an additive effect, and rIL‐1β, PGE1, and PGE2 were antagonistic. Conclusions. The results suggest that, in addition to endogenous factors, CTAP‐III and other plateletderived cytokines may play roles in regulating synovial cell metabolism in RA and OA, and that combinations of growth factors may be more significant than single agents in amplification or suppression of important cell functions.

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“…Thrombocytosis is a well known feature of active inflammation in sera from patients with rheumatoid arthritis and has been proposed to be a result of a bone marrow stress response to shortened platelet survival with platelet sequestration (30). One explanation of the lower levels of circulating thrombocytes could be production of more abundant aggregates of thrombocytes or Even if no association could be found between decreased patient survival and frequent relapses, the majority of the patients dying did so as a result of sequelae of the vasculitic disease or to cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

High Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (ANCA) Level Measured by the Capture Enzyme-Linked Immunosorbent Assay Method Is Associated with Decreased Patient Survival in ANCA-Associated Vasculitis with Renal Involvement

Westman¹,

Selga

Isberg

et al. 2003

Journal of the American Society of Nephrology

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Abstract. Wegener granulomatosis (WG) and microscopic polyangiitis (MP), diseases associated with antineutrophil cytoplasmic antibodies (ANCA), had an extremely poor prognosis before the introduction of cyclophosphamide and corticosteroids for their treatment. However, there is still reduced patient survival, and some studies have documented severe side effects of the immunosuppressants used. This 10-yr follow-up study assessed 117 consecutive patients with WG or MP with biopsy-confirmed renal involvement. The cumulative relative patient survival was lower: 0.664 for women and 0.648 for men. The causes of death (n ϭ 64) were in most cases registered as associated with the vasculitic disease. Analysis of possible predictive factors for patient survival by multiple Cox regression analysis revealed that a very high level of proteinase 3 (PR3)-ANCA measured by the capture ELISA method, a diagnosis of MP, and older age were factors predicting poorer patient survival. High levels of B-thrombocytes at time of diagnosis were associated with a better prognosis. For patients surviving the first year, remission-sustaining therapy with azathioprine for longer than 12 mo was associated with improved patient survival. Thirty-nine patients developed end-stage renal failure. Elevated serum creatinine at time of diagnosis and a very high level of PR3-ANCA by capture ELISA were factors predicting a higher risk for renal failure during follow-up. The epitope on PR3 assessed by capture ELISA needs to be further analyzed and explored: it seemed to implicate poorer patient and renal survival in WG or MP with renal involvement.

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Thrombocytosis of active rheumatoid disease.

Cited by 68 publications

References 20 publications

Response to traditional disease-modifying anti-rheumatic drugs in indigent South Africans with early rheumatoid arthritis

Response to traditional disease-modifying anti-rheumatic drugs in indigent South Africans with early rheumatoid arthritis

Connective tissue activation. xxxv. detection of connective tissue activating peptide–iii isoforms in synovium from osteoarthritis and rheumatoid arthritis patients: patterns of interaction with other synovial cytokines in cell culture

High Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (ANCA) Level Measured by the Capture Enzyme-Linked Immunosorbent Assay Method Is Associated with Decreased Patient Survival in ANCA-Associated Vasculitis with Renal Involvement

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