Thrombocytosis Is a Marker of Poor Outcome in Community-Acquired Pneumonia

Prina, Elena; Ferrer, Miquel; Ranzani, Otávio T.; Polverino, Eva; Cillóniz, Catia; Moreno, Eva María Olmedo; Mensa, Josep; Montull, Beatriz; Menéndez, Rosário; Cosentini, Roberto

doi:10.1378/chest.12-1235

Cited by 54 publications

(63 citation statements)

References 35 publications

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“…majority of the cases with radiological evidence of pneumonia or pleural effusion also developed thrombocytosis, which was similar to the results of the study by Prina et al (20). They concluded an association between thrombocytosis in patients with the community-acquired pneumonia and pleural effusion, empyema, and poor outcome (20).…”

Section: Discussionsupporting

confidence: 87%

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Thrombocytosis in Under-Five Children with Lower Respiratory Tract Infection

Choudhury

Rath

2017

Arch Pediatr Infect Dis

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Section: Discussionsupporting

confidence: 87%

“…They concluded an association between thrombocytosis in patients with the community-acquired pneumonia and pleural effusion, empyema, and poor outcome (20).…”

Section: Discussionmentioning

confidence: 99%

Thrombocytosis in Under-Five Children with Lower Respiratory Tract Infection

Choudhury

Rath

2017

Arch Pediatr Infect Dis

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“…Thrombopoietin was considered as an acute phase protein which is elevated in various inflammatory diseases, however it could not explain the cause of thrombocytosis in these cases [16]. In agreement with our results a study by Prina et al [17] considered thrombocytosis as a strong indicator for occurrence of respiratory complication of pneumonia. In contrast, thrombocytosis was not considered as an indicator for occurrence of empyema or pleural effusion in children with CAP in a study by Wolach et al [18].…”

Section: Discussionsupporting

confidence: 81%

Usefulness of gender and abnormal blood count for predicting pneumonia outcome in children

Atwa

2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Pneumonia is still a leading cause of death among children in developing countries.The aim of the study is to identify some risk factors for poor pneumonia outcome. The studied factors were: male sex, thrombocytosis, thrombocytopaenia, leucocytosis, leucopaenia and anaemia.Patients and methods: A prospective cross sectional study included 242 children with community acquired pneumonia (CAP) who were attending a tertiary care hospital. Work for the study started at October 2012 and ended at August 2014. Medical history, physical examination, complete blood count (CBC) and C-reactive protein were done for all patients.Results: 27.3% of the patients developed pulmonary complications, 17.4% acquired sepsis while death occurred in 3.7% of cases. Multinomial logistic regression was used to detect the independent effect of each studied factor. Thrombocytosis, anaemia and age 62 years were associated with the development of pulmonary complications. Thrombocytopaenia and leucopaenia were associated with the fatal course of the disease. Male sex was a protective factor against pulmonary complications; however it was a risk factor for acquiring sepsis. Leucocytosis did not affect the prognosis of CAP.Conclusion: Sex of the patient and data from complete blood count are very useful for the prediction of pneumonia outcome. Anaemia, thrombocytosis, thrombocytopaenia, and leucopaenia are considered as predictors of bad prognosis. Females are more vulnerable to pulmonary complications while maleness is associated with sepsis and determination of these indicators highlights suspicion of pneumonia prognosis and allows application of early appropriate interventions.

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“…They suggested that the presence of TP was indicative that the immune system elicited an inadequate response to the H1N1 infection. In another study involving patients with community-acquired pneumonia, those with TP more often presented with severe sepsis, septic shock, ICU admission, and the need for invasive mechanical ventilation [17]. TP was associated with higher mortality in acute kidney injury patients requiring dialysis [18].…”

Section: Discussionmentioning

confidence: 97%

Thrombocytopenia as a Marker of Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Rahimi-Rad

Soltani

Rabieepour

et al. 2015

Advances in Respiratory Medicine

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Introduction: Thrombocytopenia (TP) is associated with poor outcome in patients who are critically ill with pneumonia, burns, and H1N1 influenza. To our knowledge, no similar study in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has been conducted to date. The aim of this study was to determine the impact of platelet count on the outcome of patients with AECOPD. Material and methods: Patients admitted to our teaching hospital for AECOPD were divided into two cohorts, those with and without TP. The outcome of all patients was followed. Results: Of the 200 patients with AECOPD, 55 (27.5%) had TP. Of these, 14 (25.5%) died in the hospital, whereas of the 145 non-TP patents, 11 (7.5%) died (p-value = 0.001). There was a significantly higher transfer rate to the ICU and mechanical ventilation in TP patients. The mean platelet count was significantly lower in patients who died than those who were discharged (161,672 vs. 203,005 cell/µL; p-value = 0.017). There was negative correlation between duration of hospitalization and platelet count. Conclusion: TP was associated with poor outcome in AECOPD. TP could be considered as a marker for the assessment of inflammation and prognosis in AECOPD patients based on its cost-effective features.

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Thrombocytosis Is a Marker of Poor Outcome in Community-Acquired Pneumonia

Cited by 54 publications

References 35 publications

Thrombocytosis in Under-Five Children with Lower Respiratory Tract Infection

Thrombocytosis in Under-Five Children with Lower Respiratory Tract Infection

Usefulness of gender and abnormal blood count for predicting pneumonia outcome in children

Thrombocytopenia as a Marker of Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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