Thrombocytosis Associated With Malignant Disease

Case Report

“…IL-6 levels are commonly increased in inflammatory conditions and have been correlated with reactive thrombocytosis in humans with rheumatoid arthritis (4). Reactive thrombocytosis has also been observed in chronic inflammatory bowel disease (11), chronic pancreatitis (2), and malignant neoplastic diseases (7). Both marmosets in this report had chronic colonic disease, which may have caused an increase in the inflammatory cytokines (e.g., IL-6) leading to reactive thrombocytosis.…”

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal

“…Therefore, it is not surprising that they are crucial for tumor cell survival. Indeed, nearly 40% of people with platelet counts over 400,000 per cubic millimeter without any evidence of iron deficiency or inflammatory conditions have an occult cancer, most commonly ovarian cancer, among others (53). Aside from the clinic, experimental evidence suggests that platelets can drive tumor progression and metastasis via various mechanisms (54).…”

Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer

“…Platelets have increasingly been recognized as playing an important role in tumor growth and metastasis, in addition to their traditional roles in hemostasis (3)(4)(5)(6). Thrombocytosis (platelet count >450,000/μL) is found in 31% of patients with ovarian cancer and is associated with a poor clinical prognosis (7,8). In addition, platelets in patients with cancer are functionally altered, and often adopt a hyperreactive state (9).…”