Thrombocytosis as a prognostic factor in patients with renal cell carcinoma: A meta-analysis of literature

Men, Hai-Tao; Liang, Chunshui; Yu, Min

doi:10.4103/0973-1482.150345

Cited by 17 publications

(9 citation statements)

References 28 publications

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“…Growing evidence has reported that platelets can prevent death of cancer cells by natural killer cells, and can secrete angiogenic and tumor growth factors to promote cancer growth, progression and metastasis [ 35 – 37 ]. Furthermore, it has been reported that thrombocytosis is associated with poor prognosis in renal cancer [ 38 , 39 ]. While lymphocytes are the main components of immune system in the host and can destroy tumor cells and prevent cancer progression [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of pretreatment platelet to lymphocyte ratio in urologic cancer

et al. 2017

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The prognostic value of platelet to lymphocyte ratio (PLR) in urologic cancer does not reach a consensus. Herein, we performed the meta-analysis to determine the prognostic role of PLR in patients with urologic cancer. A literature search was performed in the PubMed, Embase, and Web of Science databases. Hazard ratios (HRs) were extracted to estimate the association between PLR and prognosis. A total of 20 articles comprising 6079 patients were included in this study. The pooled results showed that a high PLR was significantly associated with worse prognosis of overall survival (OS) in urologic cancer [HR=1.65, 95% confidence interval (CI) =1.37-1.99, P<0.01]. The result also indicated that an elevated PLR was significantly associated with poor OS in renal cancer (HR=1.88, 95% CI=1.39-2.55, P<0.01). In addition, the significant association between poor OS and elevated PLR in renal cancer was consistent regardless of treatment, cut-off value, sample size and study quality. Our result also indicated that an elevated PLR predicted shorter OS (HR=1.78, 95% CI=1.38-2.30, P<0.01) and cancer-specific survival (HR=2.02, 95% CI=1.24-3.29, P<0.01) in prostate cancer. In conclusion, an elevated PLR was a predictive indicator of poor survival in renal cancer and prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic role of pretreatment platelet to lymphocyte ratio in urologic cancer

et al. 2017

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“…More and more evidences have recognized that hemostatic variables, particularly platelet counts and plasma fibrinogen levels, have prognostic significance in patients with cancer [10–13, 17]. Platelets and fibrinogen together actively plays an important role in tumor growth, invasion and hematogenous metastasis by promoting tumour neovascularization and by supporting the sustained adhesion of tumour cells [8, 18–19].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies showed an important link between hemostatic factors and innate immunity and indicate that one mechanism by which the platelet-fibrin(ogen) axis contributes to metastatic potential is by impeding natural killer cell elimination of tumor cells [7]. In various types of cancer, thrombocytosis and PLR were proved to have a close relationship with survival outcomes [10–11, 17]. Recently, a meta-analysis of 12 studies including 8735 renal cell carcinoma patients showed thrombocytosis had a significant influence of 5-year OS and CSS in patients with localized renal cell carcinoma [17].…”

Section: Discussionmentioning

confidence: 99%

“…In various types of cancer, thrombocytosis and PLR were proved to have a close relationship with survival outcomes [10–11, 17]. Recently, a meta-analysis of 12 studies including 8735 renal cell carcinoma patients showed thrombocytosis had a significant influence of 5-year OS and CSS in patients with localized renal cell carcinoma [17]. You et al demonstrated that elevated PLR level could significantly increase the rate of overall survival outcome in colorectal cancer patients after surgery [11].…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (F-PLR) in patients with localized upper tract urothelial carcinoma

et al. 2016

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PurposeHemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC).Materials and MethodsA total of 481 patients who underwent radical nephroureterectomy for localized UTUC (pTa-4N0M0) were identified between January 2002 and June 2013. Patients were assigned a F-PLR score of 0, 1, or 2 based upon the presence of elevated plasma fibrinogen level, an elevated PLR, or both. The association between F-PLR score and clinicopathological variables was analysed.ResultsThe optimal cut-off value of plasma fibrinogen and PLR for overall survival stratification was determined to be 4.22 and 241.2. Kaplan–Meier analysis revealed significant differences in cancer specific survival (CSS) and overall survival (OS) among patients with F–PLR scores of 0, 1 and 2. Multivariate analysis identified higher F–PLR score as an independent risk factor for CSS (P < 0.001) and OS (P < 0.001). The estimated c-index of the multivariate model for CSS and OS increased from 0.772 and 0.756 to 0.799 and 0.784 when F–PLR score added, which was higher than fibrinogen level, PLR or neutrophil-to-lymphocyte ratio added.ConclusionsPreoperative F-PLR score is a negative independent prognostic factor for survival outcomes in patients with localized upper tract urothelial carcinoma. Preoperative F-PLR score may become a useful biomarker, particularly because of its low associated cost and easy accessibility.

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“…Thrombocytosis has been identified as an adverse prognostic indicator in lung cancer [ 7 ], esophageal cancer [ 8 ], renal cell carcinoma [ 9 ], and gynecological malignancies [ 10 11 ], and breast cancer [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Preoperative thrombocytosis predicts prognosis in stage II colorectal cancer patients

Lee

Suh

2016

Ann Surg Treat Res

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PurposeThrombocytosis is known to be a poor prognostic factor in several types of solid tumors. The prognostic role of preoperative thrombocytosis in colorectal cancer remains limited. The aim of this study is to investigate the prognostic role of preoperative thrombocytosis in stage II colorectal cancer.MethodsTwo hundred eighty-four patients with stage II colorectal cancer who underwent surgical resection between December 2003 and December 2009 were retrospectively reviewed. Thrombocytosis was defined as platelet > 450 × 109/L. We compared patients with thrombocytosis and those without thrombocytosis in terms of survival.ResultsThe 5-year disease-free survival (DFS) rates were lower in patients with thrombocytosis compared to those without thrombocytosis in stage II colorectal cancer (73.3% vs. 89.6%, P = 0.021). Cox multivariate analysis demonstrated that thrombocytosis (hazard ratio, 2.945; 95% confidence interval, 1.127–7.697; P = 0.028) was independently associated with DFS in patients with stage II colorectal cancer.ConclusionThis study showed that thrombocytosis is a prognostic factor predicting DFS in stage II colorectal cancer patients.

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Thrombocytosis as a prognostic factor in patients with renal cell carcinoma: A meta-analysis of literature

Abstract: Thrombocytosis indicates worse OS and CSS for patients with RCC, and it showed stronger specificity or sensitivity for CSS. Thrombocytosis is more frequently in patients with metastatic RCC but only showed significant influence on survival of localized RCC patients.

Cited by 17 publications

References 28 publications

Prognostic role of pretreatment platelet to lymphocyte ratio in urologic cancer

Prognostic role of pretreatment platelet to lymphocyte ratio in urologic cancer

Prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (F-PLR) in patients with localized upper tract urothelial carcinoma

Preoperative thrombocytosis predicts prognosis in stage II colorectal cancer patients

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