Thrombocytopenic Purpura in Toluene Di-Isocyanate Workers

Jennings, G. H.; Gower, N.D.

doi:10.1016/s0140-6736(63)92301-8

Cited by 22 publications

(9 citation statements)

References 6 publications

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“…In the only previous report of thrombocytopenic purpura associated with toluene di-isocyanate, the two adult patients were not rechallenged [4]. The fact that no other family member had petechiae suggests that the effect of polyurethane is idiosyncratic.…”

Section: Discussionmentioning

confidence: 83%

“…The fact that no other family member had petechiae suggests that the effect of polyurethane is idiosyncratic. The mechanism of polyurethane-induced thrombocytopenia is probably immunological in view of a) the delay between exposure and the onset of thrombocytopenic purpura (in this case and the previous cases of toluene di-isocyanate exposure [4]); b) the increase in megakaryocytes in the bone marrow (in this and previous cases [4]); c j the lack of response to a platelet transfusion but cure by splenectomy in a previous case [4]; and, d) the response to steroids and high-dose immune globulin in the present case.…”

Section: Discussionmentioning

confidence: 92%

“…The aromatic hydrocarbons toluene di-isocyanate and xylene are widely used in the production of foam plastics and other polyurethane materials, including protective resins for floors and walls [4]. The usual routes of entry into the body are inhalation (solvent fumes) and dermal (direct contact) [4].…”

Section: Discussionmentioning

confidence: 99%

“…The usual routes of entry into the body are inhalation (solvent fumes) and dermal (direct contact) [4].…”

Section: Discussionmentioning

confidence: 99%

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Thrombocytopenia associated with environmental exposure to polyurethane

Michelson

1991

American J Hematol

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Few chemicals in the environment have been implicated as causes of isolated thrombocytopenia, and the evidence is usually less than convincing because the patients were not rechallenged with the chemical in vivo. In the present paper, a child is reported with the onset of thrombocytopenia in temporal association with environmental exposure to polyurethane. Five years after the initial thrombocytopenia had resolved, an inadvertent in vivo rechallenge with environmental polyurethane resulted in recurrence of the thrombocytopenia. This recurrence, together with the fact that only 1-4% of cases of idiopathic thrombocytopenic purpura in children recur, provided strong evidence for a causal role for the polyurethane exposure in this patient's thrombocytopenia. In summary, environmental exposure to polyurethane should be considered in the differential diagnosis of acquired thrombocytopenia in childhood.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…The usual routes of entry into the body are inhalation (solvent fumes) and dermal (direct contact) [4].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Thrombocytopenia associated with environmental exposure to polyurethane

Michelson

1991

American J Hematol

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“…Exposure to isocyanates may cause health risks, mainly in occupational environment. The most common disease is asthma (3), while allergic or irritant contact dermatitis (4), contact urticaria (5) and systemic toxicity (6) have been rarely reported.…”

Section: Discussionmentioning

confidence: 99%