Thrombocytopenic Purpura and Chickenpox

Welch, R. G.

doi:10.1136/adc.31.155.38

Cited by 21 publications

(3 citation statements)

References 29 publications

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“…ITP-VZV typically resolves spontaneously within 1 to 3 weeks. 28,31 Occasionally, the course is protracted and requires ITP therapy. 28 Hepatitis C virus: ITP-HCV.…”

Section: Cytomegalovirus: Itp-cmvmentioning

confidence: 99%

The ITP syndrome: pathogenic and clinical diversity

Cines

Bussel

Liebman

et al. 2009

Blood

706

560

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Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate platelet destruction and inhibit their production. Most cases are considered idiopathic, whereas others are secondary to coexisting conditions. Insights from secondary forms suggest that the proclivity to develop platelet-reactive antibodies arises through diverse mechanisms. Variability in natural history and response to therapy suggests that primary ITP is also heterogeneous. Certain cases may be secondary to persistent, sometimes inapparent, infections, accompanied by coexisting antibodies that influence outcome. Alternatively, underlying immune deficiencies may emerge. In addition, environmental and genetic factors may impact platelet turnover, propensity to bleed, and response to ITP-directed therapy. We review the pathophysiology of several common secondary forms of ITP. We suggest that primary ITP is also best thought of as an autoimmune syndrome. Better understanding of pathogenesis and tolerance checkpoint defects leading to autoantibody formation may facilitate patientspecific approaches to diagnosis and management. (Blood. 2009;113:6511-6521)

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“…ITP-VZV typically resolves spontaneously within 1 to 3 weeks. 28,31 Occasionally, the course is protracted and requires ITP therapy. 28 Hepatitis C virus: ITP-HCV.…”

Section: Cytomegalovirus: Itp-cmvmentioning

confidence: 99%

The ITP syndrome: pathogenic and clinical diversity

Cines

Bussel

Liebman

et al. 2009

Blood

706

560

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“…The reported complications of varicella include cutaneous superinfection, epistaxis secondary to shedding of crusts in the nasal mucosa, encephalomyelitis, idiopathic thrombocytopenic purpura, pneumonia, ulcerative keratitis, myocarditis, pericarditis, pancreatitis complicated by pancreatic pseudocyst and duodenal obstruction, hepatitis, nephritis, orchitis, arthritis, and myositis (8)(9)(10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Varicella and Perforation of the Stomach

Paret,

Yahav,

Cohen

et al. 1990

J. pediatr. gastroenterol. nutr.

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“…The earliest description is that of Berard and de Lavit in 1816 and we have found published accounts of some 40 cases since then, excluding those on steroids or with pre-existing chronic disease (Andrew, 1890;Hamann, 1892de Lannoise, 1896Lockwood, 1897;Grancher and Comby, 1904;Rundle, 1906;Porter, 1907;Alexander, 1909;Elliott, 1910 ;Knowles, 1911 ;Storrie, 1914 ;Campbell, 1915 ;Whitaker, 1915;Shanks, 1922;Wanklyn, 1922;Gordon and Rolleston, 1927;Knauer, 1927;Apert and Goldberg, 1930;Slim, 1930;Tancredi, 1933 ;Cohen, 1936;Mir, 1938;Stoesser and Lockwood, 1938;Ford and Marin, 1944;Cohen and Bansmer, 1947;Marsden and Coughlan, 1952;Ghosh et al, 1955 ;Welch, 1956;Krugman et al, 1957;Charkes, 1961 ;Rotem, 1961). Among these cases 10 fatalities are recorded.…”

Section: Discussionmentioning

confidence: 99%