Thrombocytopenia with absent radii (TAR) syndrome: A new increased cellular radiosensitivity syndrome

Symonds, R.P.; Clark, Barry; George, W.D.; Bryant, Peter E.; Liu, N.; Connor, Jason

doi:10.1016/s0936-6555(05)80640-5

Cited by 5 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In any case, the fact that these entities are very infrequent suggests that their coincidence is not due to chance. The association of TAR syndrome with different types of cancer has been reported previously (5)(6) supporting the idea that there is an increased risk of neoplasia in this condition.…”

Section: Discussionsupporting

confidence: 83%

“…It is characterized by the association of thrombocytopenia, usually more intense during the neonatal period, and bilateral radial aplasia or hypoplasia. A great variability of associated abnormalities involving ihe skin, the eyes and skeletal, gastrointestinal, renal and cardiac systems have been reported (4)(5)(6). In addition some of the patients reported so far developed haematological and solid organ tumours (6-7).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Progressive Nodular Histiocytoma Associated with Thrombocytopenia with Absent Radii (TAR Syndrome) and Angiofibromas

Rosón¹,

Flórez²,

Feal³

et al. 2006

Acta Derm Venereol

View full text Add to dashboard Cite

A 50-year-old woman was admitted due to a long-standing history of cutaneous lesions, which were gradually increasing in number and size, located on the trunk and extremities. Histological studies confirmed the initial clinical diagnosis of histiocytomas. Moreover, the patient had numerous smooth erythematous papules on her chin and around her nose, which were diagnosed histologically as angiofibromas. The patient had congenital phocomelia. Analytical and imaging studies revealed the presence of bilateral phocomelia due to absent radii and thrombocytopenia (TAR syndrome). Multiple histiocytomas in a normolipaemic patient bring up several differential diagnoses. Slow progressive evolution without spontaneous resolution and a scattered distribution on the trunk and extremities suggest the diagnosis of progressive nodular histiocytoma. To our knowledge progressive nodular histiocytoma has not been reported previously associated either with TAR syndrome or with angiofibromas. These entities are uncommon, thus their association may not be due to chance.

show abstract

Section: Discussionsupporting

confidence: 83%

mentioning

confidence: 99%