Thrombocytopenia in term infants: a population-based study

Sainio, Susanna; Järvenpää, Anna‐Liisa; Renlund, Martin; Riikonen, Seija; Teramo, Kari; Kekomäki, Riitta

doi:10.1016/s0029-7844(99)00543-8

Cited by 76 publications

(82 citation statements)

References 17 publications

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“…24 Also, this study confirmed that the CB PLT count is higher after vaginal delivery than after Cesarean section. 25 Recently, PLT count and MPV reference ranges for the first 3 days of life were reported for neonates in a large, multi-hospital study.…”

Section: Discussionsupporting

confidence: 76%

Association of cord blood platelet count and volume with hemoglobin in healthy term infants

et al. 2010

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Objective: The aim of this study was to investigate relationships of cord blood cells in healthy term infants both from vaginal and Cesarean sections.Study Design: The study sample comprised 167 consecutive cord blood collections accepted for processing in an accredited cord blood bank. The effect of varying anticoagulant-to-blood ratio was excluded by standardizing the cell concentrations to reflect the values in native blood. Statistical analysis included descriptive statistics, simple linear regression analysis, MannWhitney U-test, cumulative frequency plots and Smirnov two-sample test.Result: As expected, hemoglobin correlated with red blood cell concentration. Interestingly, mean platelet volume was associated with hemoglobin, red blood cell concentration and hematocrit. The platelet count was inversely associated with the parameters. Conclusion:The observed associations of cord blood hemoglobin with mean platelet volume and platelet count reflect the physiology of fetal hematopoiesis at term.

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Section: Discussionsupporting

confidence: 76%

Association of cord blood platelet count and volume with hemoglobin in healthy term infants

et al. 2010

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“…After critical appraisal of the full text of the remaining 21 articles independently by 2 authors (MK and NP), 6 studies were included in the review. 1,2,[8][9][10][11] The main reason for exclusion was that screening was not performed in a low-risk population but in newborns selected by the history of siblings who suffered from fetal and neonatal alloimmune thrombocytopenia (FNAIT) during pregnancy or at birth. Another important reason for exclusion was the use of case finding through maternal HPA-1a typing in unselected pregnant women, with further analysis in those women who were typed negative for HPA-1a.…”

Section: Systematic Literature Searchmentioning

confidence: 99%

“…The other 3 studies focused on neonatal thrombocytopenia. 1,8,10 One study analyzed 2 control groups to identify the incidence of alloimmunization in respectively thrombocytopenic mothers of nonthrombocytopenic newborns and nonthrombocytopenic mothers of nonthrombocytopenic newborn. 2 The difference was statistically significant between the group of mothers with thrombocytopenic newborns and the control groups but not between the 2 control groups Only 1 paper reported a sample size calculation 1 ; all the others chose a fixed time period, varying from 1 to 7 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Incidence and Consequences of Neonatal Alloimmune Thrombocytopenia: A Systematic Review

Kamphuis¹,

Paridaans²,

Porcelijn

et al. 2014

Pediatrics

102

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BACKGROUND: Neonatal alloimmune thrombocytopenia (NAIT) is a potentially devastating disease that may lead to intracranial hemorrhage in the fetus or neonate, often with death or major neurologic damage. There are no routine screening programs for NAIT, preventive measures are taken only in a subsequent pregnancy. To estimate the population incidence of NAIT and its consequences, we conducted a review of the literature. Our results may aid in the design of a screening program.METHODS: An electronic literature search included Medline, Embase, Cochrane database and references of retrieved articles. Eligible for inclusion were all prospective studies aimed at diagnosing NAIT in a general, nonselected newborn population, with sufficient information on platelet count at birth, bleeding complications, and treatment. Titles and abstracts were reviewed, followed by review of full text publications. Studies were independently assessed by 2 reviewers for methodologic quality. Disagreements were resolved by consensus, including a third reviewer.

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“…Accelerated consumption of thrombocytes and their sequestration from blood are the main causes of 25% to 35% neonatal thrombocytopenia. Out of all thrombocytopeniae manifested at birth, 15% to 20% are result of transplacental transmission of mother's antibodies, and disseminated intravascular coagulation, which is responsible for the remaining 10% to 15% cases, almost always occurs in the newborn with poorer clinical status and is connected with prenatal asphyxia and infection [3][4][5]. The newborn may develop thrombocytopenia due to various neonatal complications, such as: infection, perinatal asphyxia, respiratory distress syndrome, polycythaemia and necrotizing enterocolitis.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia: Diagnostic Tool of Neonatal Infection?

Brzica¹,

Raguž²,

Mikulić³

et al. 2017

Gynecol Obstet Case Rep

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Objective:To research the occurrence of thrombocytopenia in the newborn and to establish the connection of thrombocytopenia with risk factors. Materials and methods:The study encompassed 136 newborn, to whom thrombocytopenia diagnosis was confirmed in laboratory test, and who were treated at the neonatal intensive care unit (NICU) at the Clinic for Children's Diseases at the University Clinical Hospital in Mostar (SKB) in Mostar. Results:Out of the total number of 1164 newborn who were treated at the NICU during a two-year period, 2013/2014, at the University Clinical Hospital in Mostar, 136 (11.7%) newborn had thrombocytopenia. Risk factors from mother's side that affected development of thrombocytopenia were medications 53.7%, cigarettes consumption 56.6% and complications at delivery 34.6%. Placental insufficiency occurred in 32.4% newborn. Out of the total number of the newborn with thrombocytopenia, 38.2% suffered from some kind of infection (sepsis, urinary system infection, bacteraemia...), which is one of the main risk factors for development of thrombocytopenia on the side of the newborn. The most frequently isolated cause was Escherichia coli, which was isolated in 19.9% examinees. Conclusion:This study shows that the most important risk factors for development of thrombocytopenia in the newborn at the NICU are the risk factors on the side of the mother.

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Thrombocytopenia in term infants: a population-based study

Abstract: Immunologic studies should be considered in all cases of severe neonatal thrombocytopenia for careful monitoring and prevention of potentially severe complications in subsequent pregnancies.

Cited by 76 publications

References 17 publications

Association of cord blood platelet count and volume with hemoglobin in healthy term infants

Association of cord blood platelet count and volume with hemoglobin in healthy term infants

Incidence and Consequences of Neonatal Alloimmune Thrombocytopenia: A Systematic Review

Thrombocytopenia: Diagnostic Tool of Neonatal Infection?

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