Thrombocytopenia in Children Infected with Human Immunodeficiency Virus

Rigaud, Mona; Leibovitz, Eugene; Quee, Corinne Sin; Kaul, Aditya; Nardi, Michael A.; Pollack, Henry; Lawrence, Robert M.; DiJohn, David; Krasinski, Keith; Karpatkin, Margaret; Borkowsky, William

doi:10.1097/00126334-199205000-00003

Cited by 24 publications

(13 citation statements)

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“…Early in the epidemic, Duliege and colleagues [14] raised awareness with their report that a number of factors, including bacterial, viral or opportunistic infections, nutritional diseases, neurological disorders, and thrombocytopenia, might be associated with HIV related causes of death among children in California. Similarly, although not the original purpose of the report, a high mortality rate was evident in Rigaud's series [162] in which 36% of the thrombocytopenic children died. While HIV mortality was quite high early in the HIV epidemic, the overall rate of mortality seems to be even higher in this thrombocytopenic group.…”

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 76%

“…It has been suggested by the New York State Department of Health [102], among others, that antiretroviral therapy be the primary treatment of HIV-associate thrombocytopenia unless it has proven to be ineffective or the patient requires an immediate increase in platelets. Even so, zidovudine responses in children with thrombocytopenia seem to be poorer than those observed in adults [162]. According to Rigaud [162], only 30% of HIV infected thrombocytopenic children responded to zidovudine treatment for a period of 3-20 months (Table 1).…”

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 99%

“…Newman [164] showed that a high dose of intravenous anti-D (75 g/kg/d) resulted in overnight platelet increases in a significant number of pediatric cases. Bussel (n=2) and Rigaud (n=8) have reported small case series clinical responses of the use of intravenous immunoglobulins in HIV infected children [162,165]. With no existing up-todate treatment guidelines, Rigaud described her clinical experiences as a struggle to provide appropriate treatment for HIV infected children with thrombocytopenia for a period of over 18 months.…”

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 99%

“…With no existing up-todate treatment guidelines, Rigaud described her clinical experiences as a struggle to provide appropriate treatment for HIV infected children with thrombocytopenia for a period of over 18 months. Despite clinical evidence of IVIG's efficacy in HIV (-) thrombocytopenic patients, only transient increases in platelet counts were observed in HIV infected thrombocytopenic children [162]. For those who became refractory to IVIG, corticoids were attempted, however, its results were also restricted to a small group of HIV infected thrombocytopenic children [162].…”

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 99%

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Thrombocytopenia in HIV Disease: Clinical Relevance, Physiopathology and Management

Míguez‐Burbano¹,

Jackson²,

Hadrigan³

2005

CMCCHA

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HIV infection is associated with a myriad of hematopoietic abnormalities. Thrombocytopenia (TCP), the condition in which platelet counts fall below 150x10(3)/mm3 in two or more consecutive platelet counts, is a condition frequently seen in HIV infected individuals regardless of HIV status, gender, or age. Having recently been associated with rapid disease progression, and by complicating the management of AIDS patients, thrombocytopenia has become a medical challenge, highlighting the urgent need for evidence-based treatment protocols in this area. Due to the physiopathology of HIV, therapeutic options currently available for TCP in this already vulnerable population are severely limited. Whereas clinicians often intervene to prevent life-threatening, thrombocytopenia-associated outcomes in the general population, there is no intervention protocol: for the HIV subjects. Management of the condition seems to be the norm for these individuals. As a result, thrombocytopenia in HIV is a subject that is in urgent need of re-examination. In this review, the importance of thrombocytopenia and current knowledge regarding the physiopathology of HIV-associated thrombocytopenia is discussed, and an overview of current and under-investigation treatment approaches to this adverse hematological condition is provided.

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Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 76%

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 99%

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 99%

Section: Treatment Of Hiv Infected Childrenmentioning

confidence: 99%

See 2 more Smart Citations

Thrombocytopenia in HIV Disease: Clinical Relevance, Physiopathology and Management

Míguez‐Burbano¹,

Jackson²,

Hadrigan³

2005

CMCCHA

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“…À semelhança do que é referido em literatura 9,16 , observou-se plaquetopenia em 10 a 25% das crianças. Em adultos, tal freqüência varia de 8 a 30% 38 .…”

Section: Discussionunclassified

Evolution of hematological parameters in a group of children with human immunodeficiency virus infection - HIV 1

Silva¹,

Silva²,

Vilela³

1999

J Pediatr (Rio J)

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Objective: To analyze the evolution of clinical and hematological aspects of the children infected with HIV 1.Methods: Using the CDC criteria, 1994, 37 children with HIV infection were selected, followed up at the Immunodeficiency Clinic at UNICAMP. The study is longitudinal descriptive. Complete blood count, ferritin, serum iron, TIBC and direct Coombs were carried out.Results: The clinical category that predominated was B (45.94%) and categories A and C were equal (27.03%). All of them were having antiretroviral therapy. Hypochromic and microcytic anemia were seen in 100% of patients up to 12 months of age. There was association between anemia and the progression of the disease, both clinical (p=0.031) and immunological (p=0.0027) and with lymphopenia too (p=0.033). Thrombocytopenia occurred in 10 to 25% of the patients. Low serical ferritin was seen in 2.7% of the cases and low serum iron in 11.1%. All the 15 patients analyzed had negative Coombs test. There was weight and height reduction in 23.5 to 45% of the children and 70.3% had clinical manifestations up to 9 months of age. During the follow up 13.2% of the patients died.Conclusions: There was association between anemia and lymphopenia with the progression of the disease. In relation to the aetiology of the anemia, about 10% can be considered anemia of chronic disease. Probably the hematological abnormalities seen in peripheral blood are the consequences of loss of control of cellular death mechanism and hematopoiesis in individuals infected by HIV 1.J. pediatr. (Rio J.). 1999; 75(6): 442-448: acquired immunodeficiency syndrome, anemia, lymphopenia.

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Inherited and Congenital Thrombocytopenia

Smith¹

2006

Pediatric Hematology

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Thrombocytopenia in Children Infected with Human Immunodeficiency Virus

Cited by 24 publications

References 0 publications

Thrombocytopenia in HIV Disease: Clinical Relevance, Physiopathology and Management

Thrombocytopenia in HIV Disease: Clinical Relevance, Physiopathology and Management

Evolution of hematological parameters in a group of children with human immunodeficiency virus infection - HIV 1

Inherited and Congenital Thrombocytopenia

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