Thrombocytopenia at baseline is a predictor of inhospital mortality in patients undergoing percutaneous coronary intervention

Thrombotic events in patients with antiplatelet factor 4/heparin antibodies

“…Patients with heparin-induced thrombocytopenia have an increased rate of bleeding complications, ischaemic events and early mortality18 19 Vanderschueren and co-workers evaluated the prognostic significance of thrombocytopenia in patients admitted to an intensive care unit, and found that it is a powerful predictor of adverse events 20. A similar finding was reported by Overgaard et al : in patients referred for PCI, baseline thrombocytopenia was an independent predictor of in-hospital mortality 19…”

Comparison of Equipressor Doses of Norepinephrine, Epinephrine, and Phenylephrine on Septic Myocardial Dysfunction

“…Myocardial function was explored with a conductance catheter placed in the left ventricle, which is the gold standard for myocardial function assessment, 16 and with micro positron emission tomography (PET), a new tool allowing the exploration of myocardial metabolism and myocardial function. 17 We thus hypothesized that infusion of recommended vasopressors in septic shock induces different effects on intrinsic myocardial function and myocardial efficiency 18 and both explorative methods are complementary to fully characterize global hemodynamics and cardiac contractility during septic shock.…”

Baseline Platelet Count and Clinical Outcome in Acute Coronary Syndrome

“…Although the trend of protective effect of middle PLT as compared with the bottom PLT was seen in several studies, 11,12,20,23 a single study demonstrating that thrombocytopenia at baseline is an independent predictor was conducted by Overgaard et al in 2008. 13 Explanations of the prognostic value of PLT might require multiple mechanisms. First, the role of platelets in the inflammation at a local vascular level might partially account for the results.…”

“…After removing the single study in which PLTs were divided into 2 segments, 13 Subgroup analyses were available in the patients at 1-month follow-up. We found that the pooled risk estimate adjusted for confounders was significantly higher than that without adjusting in the top PLT group (RR=1.70 vs. RR=1.41; P<0.01), and in the middle PLT group (RR=1.24 vs. RR=0.79; P<0.01).…”

“…Disease at baseline was ACS in 8 studies; 10,11,20- 23 Overgaard et al reported the outcomes of ACS and non-ACS patients, respectively. 13 The quality of the included studies was assessed using a modified method (Table S1). All studies were high quality, as indicated in Table 1.…”