Thrombocytopenia and pulmonary hypertension in the perinatal aspiration syndromes

Segall, Michael; Goetzman, Boyd W.; Schick, James B. M.

doi:10.1016/s0022-3476(80)80754-2

Cited by 28 publications

(9 citation statements)

References 10 publications

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“…For example, prolonged indwelling catheters, respiratory distress, and mechanical ventilation can all increase PLT consumption. [22][23][24][25][26][27] Figure 4 illustrates that thrombocytopenia is more persistent than generally recognized, particularly in the smallest infants. Noninfected, unventilated, AGA infants born at less than 27 weeks gestation exhibited prolonged risk of thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Thrombocytosis and Thrombocytopenia in Hospitalized Neonates

McPherson

Juul

2004

J Perinatol

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We sought to identify changes in platelet (PLT) counts over time, and to evaluate the patterns of thrombocytopenia and thrombocytosis in hospitalized infants 23.8 weeks to term gestation. STUDY DESIGN:Neonates were divided into four gestational age groups and their PLT counts were retrospectively compared for prevalence of thrombocytopenia, thrombocytosis, and associated conditions. RESULTS:Postconceptional age, postnatal age, and sepsis (among other factors) affected PLT counts. When counts from noninfected appropriately grown infants were evaluated, the risk of thrombocytopenia and thrombocytosis were highest in the most preterm infants, and these risks changed with corrected gestational age. PLT counts increased weekly over the first 4 weeks of life for all but the most preterm infants. CONCLUSIONS:These data characterize the incidence of thrombocytopenia and thrombocytosis across a wide range of gestational ages and show that, even in noninfected neonates, these conditions are common, and risk decreases with increasing maturity. The age-related changes in PLT patterns may reflect maturation of platelet regulation.

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Section: Discussionmentioning

confidence: 99%

Patterns of Thrombocytosis and Thrombocytopenia in Hospitalized Neonates

McPherson

Juul

2004

J Perinatol

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“…As shown in the Figure , 14 articles qualified for inclusion following the review of full articles from the database searches, and an additional 6 articles were identified from the review of bibliographies, giving a total of 20 included studies. Ten studies presented data on the occurrence of pulmonary hypertension in children classified under the umbrella terms ILD/chILD, or DLD, and 10 studies presented data on the frequency of pulmonary hypertension in specific types of chILD . Three studies were identified that reported mortality rates and/or the effect of pulmonary hypertension on mortality among children with ILD classified under broad ILD groups.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary hypertension in childhood interstitial lung disease: A systematic review of the literature

Bromley

Vizcaya

2016

Pediatric Pulmonology

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Childhood interstitial lung disease (chILD) comprises a wide heterogeneous group of rare parenchymal lung disorders associated with substantial morbidity and mortality. Pulmonary hypertension is a common comorbidity in adults with interstitial lung disease (ILD) and associated with poor survival. We aimed to systematically review the literature regarding the occurrence of pulmonary hypertension (PH) in chILD, its effect on prognosis and healthcare use, and its treatment in clinical practice. Searches of PubMed and EMBASE databases (up to February 2016), and American Thoracic Society conference abstracts (2009-2015) were conducted using relevant keywords. References from selected articles and review papers were scanned to identify further relevant articles. A total of 20 articles were included; estimates of PH in chILD ranged from 1% to 64% with estimates among specific chILD entities ranging from 0% to 43%. Comparisons between studies were limited by differences in the study populations, including the size, age range, and heterogeneous composition of the ILD case series in terms of the nature and severity of the clinical entities, and also the methods used to diagnose PH. Three studies found that among patients with chILD, those with PH had a significantly higher risk (up to sevenfold) of death compared with those without PH. Information on the treatment of pulmonary hypertension in chILD or the effect of PH on healthcare use was not available. Data on the use and effectiveness of treatments for pulmonary hypertension in chILD are required to address this area of unmet need. Pediatr Pulmonol. 2017;52:689-698. © 2016 Wiley Periodicals, Inc.

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“…This metabolite also appears to play an important role in the pulmonary hyper tension induced in newborn animals by en dotoxin and group B streptococcal sepsis, mediating the immediate gas exchange ab normalities and hypoxemia that develops in these experimental situations [10,11]. In addition, thromboxane A2 may mediate the persistent pulmonary hypertension that ac companies perinatal aspiration [18,19]. In tralipid infusion in lambs has been associ ated with increased thromboxane produc tion and increased pulmonary arterial pres sure [20].…”

Section: Discussionmentioning

confidence: 99%

Decreased Plasma Arachidonic Acid Binding Capacity in Neonates

Pd¹,

Rw²,

Clark³

et al. 1987

Neonatology

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Arachidonic acid (AA) metabolites have been implicated in neonatal pathologic states such as respiratory distress syndrome (RDS). Since free (nonprotein bound) AA is the substrate for synthesis of these compounds, a decreased capacity to bind AA in neonatal plasma could contribute to these disorders. AA binding was assayed by equilibrium dialysis in plasma samples from healthy adults and various infant groups. Plasma from these infant groups bound significantly less AA than adult plasma. Premature infants with RDS and premature infants receiving intralipid had the lowest capacity to bind AA. The increased availability of free AA may be important in neonatal pathophysiologic states involving arachidonate metabolites.

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Thrombocytopenia and pulmonary hypertension in the perinatal aspiration syndromes

Cited by 28 publications

References 10 publications

Patterns of Thrombocytosis and Thrombocytopenia in Hospitalized Neonates

Patterns of Thrombocytosis and Thrombocytopenia in Hospitalized Neonates

Pulmonary hypertension in childhood interstitial lung disease: A systematic review of the literature

Decreased Plasma Arachidonic Acid Binding Capacity in Neonates

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