Geç Neonatal Sepsi̇s Tanisinda Trombosi̇t Parametreleri̇ Ve Nötrofi̇l Lenfosi̇t Oranlarinin Değerlendi̇ri̇lmesi̇

Yalınbaş, Emine Esin; Bilgin, Hüseyin

doi:10.18229/kocatepetip.557896

Cited by 2 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In their study, Yalınbaş et al determined that leukocyte levels, neutrophil levels, PLR and NLR values were higher in sepsis patients compared to the healthy control group (7).…”

Section: Discussionmentioning

confidence: 94%

“…Despite the availability of many screening tests used in the early diagnosis of sepsis, the sensitivity of these tests varies between 30% and 90% (7). This study attempted to evaluate the hemogram, biochemical and inflammatory markers involved in the diagnosis, pathology and progression of sepsis and to determine the relationship between these markers.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation and Diagnostic Effectiveness of Hemogram, Biochemistry and Inflammatory Markers (Immature Granulocyte, Procalcitonin, Crp, Nlr, Plr) in Patients With Sepsis

Gedik

Çiftçioğlu

2023

Eurasian Journal of Critical Care

View full text Add to dashboard Cite

Aim This study aimed to reveal the contributions of hemogram values and inflammatory markers involved in the pathology and progression of sepsis, and other biochemical markers such as C-reactive protein, procalcitonin, delta neutrophil index (immature granulocyte), calcium and zinc levels to the diagnosis of sepsis, and the relationship of these markers with each other. Material and Method This is a descriptive epidemiological study. Patients aged 18 years and over who were diagnosed with sepsis in the Emergency Department and Internal Diseases Service of Kahramanmaraş Sütçü Imam University Medical Faculty Hospital between 11.10.2022 - 11.06.2023 were prospectively included in the study. Results In our study, it was found that leukocyte, neutrophil, neutrophil lymphocyte ratio, platelet lymphocyte ratio, immature granulocyte, copper, phosphorus, blood glucose, C-reactive protein and procalcitonin values were high in patients with sepsis. The levels of albumin, calcium, zinc and lymphocyte were found to be low. Conclusion The use of biomarkers in sepsis has increasingly become important in diagnosing, following treatment, determining prognosis and predicting mortality. The biomarkers examined in this study are believed to be a reference for future studies on their use in the diagnosis, treatment and prognosis follow-up of sepsis.

show abstract

“…In their study, Yalınbaş et al determined that leukocyte levels, neutrophil levels, PLR and NLR values were higher in sepsis patients compared to the healthy control group (7).…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Evaluation and Diagnostic Effectiveness of Hemogram, Biochemistry and Inflammatory Markers (Immature Granulocyte, Procalcitonin, Crp, Nlr, Plr) in Patients With Sepsis

Gedik

Çiftçioğlu

2023

Eurasian Journal of Critical Care

View full text Add to dashboard Cite

show abstract

Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis

Chen,

Yasrebinia,

Ghaedi

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

Introduction The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis. Methods PubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022. Results Thirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14–2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40–3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63–1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62–90%), and a pooled specificity of 91% (95% CI = 73–97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76–3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69–0.86%), and a pooled specificity of 73% (95% CI = 54–85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63–0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55–0.80), and the pooled specificity was 0.80 (95% CI, 0.68–0.88). Conclusion Our findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems.

show abstract

Geç Neonatal Sepsi̇s Tanisinda Trombosi̇t Parametreleri̇ Ve Nötrofi̇l Lenfosi̇t Oranlarinin Değerlendi̇ri̇lmesi̇

Cited by 2 publications

References 19 publications

Evaluation and Diagnostic Effectiveness of Hemogram, Biochemistry and Inflammatory Markers (Immature Granulocyte, Procalcitonin, Crp, Nlr, Plr) in Patients With Sepsis

Evaluation and Diagnostic Effectiveness of Hemogram, Biochemistry and Inflammatory Markers (Immature Granulocyte, Procalcitonin, Crp, Nlr, Plr) in Patients With Sepsis

Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis

Contact Info

Product

Resources

About