Thrombocyte functions in the avian immune system

Astill, Jake; Wood, Richard D.; Sharif, Shayan

doi:10.1016/b978-0-12-818708-1.00006-3

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…As stated above, Table S2 [ 33 ] also provides a list of MHC II gene expressions associated with antigen processing and presentation (e.g., DM). Various roles for chicken thrombocytes in adaptive immunity have been covered by Astill et al [ 84 ], who characterized the avian thrombocyte as a central cell in the immune system. Considering the full range of functions identified for avian and fish thrombocytes, it is apropos to consider this cell as a major component of innate and adaptive immunities in a context greater than blood coagulation and phagocytosis.…”

Section: Participation In Adaptive Immunitymentioning

confidence: 99%

The Immunological Capacity of Thrombocytes

Ferdous,

Scott

2023

IJMS

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Thrombocytes are numerous in the blood of aves (birds) and ichthyoids (fish). The origin of this cell type is a common hematopoietic stem cell giving rise to a cell that is active in blood coagulation, inflammatory functions, and the immune response in general. It has been well documented that thrombocytes can phagocytize small particles and bacteria. While phagocytosis with an associated oxidative burst has been reported for chicken thrombocytes, some questions remain as to the degradation capacity of phagosomes in ichthyoids. As innate cells, thrombocytes can be stimulated by bacterial, viral, and fungal pathogens to express altered gene expression. Furthermore, there have been observations that led researchers to state that platelets/thrombocytes are capable of serving as “professional antigen presenting cells” expressing CD40, CD80/86, MHC I, and MHC II. This indeed may be the case or, more likely at this time, provide supporting evidence that these cells aid and assist in the role of professional antigen-presenting cells to initiate adaptive immune responses.

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Section: Participation In Adaptive Immunitymentioning

confidence: 99%

The Immunological Capacity of Thrombocytes

Ferdous,

Scott

2023

IJMS

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“…At 14 dpi, monocyte levels had recovered, and a significant decrease in the percentage of thrombocytes and an increase in the percentage of heterophils were observed. Monocytes, thrombocytes, and heterophils are all part of the innate immune system with the ability to kill microbes through phagocytosis, release of granule contents, and production of inflammatory cytokines [ 58 ]. An increase in blood monocytes following oral Salmonella infection has previously been seen in mice [ 59 ], while heterophils have been found to be an important factor in controlling Salmonella infections in poultry [ 60 ] via the release of the antimicrobial peptide Cathelicidin-2 [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Salmonella Typhimurium Colonization on Microbiota Maturation and Blood Leukocyte Populations in Broiler Chickens

Robinson

Assumpcao

Arsi

et al. 2022

Animals

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Reducing Salmonella in commercial chickens is vital to decreasing human salmonellosis infections resulting from contact with contaminated poultry and poultry products. As the intestinal microbiota plays an important role in preventing pathogen colonization, we sought to understand the relationship between Salmonella infection and the cecal microbiota and the host immune system. Day-of-hatch broiler chicks were assigned to three treatments: control, artificial (SA), and natural (SN) Salmonella infection. At seven days of age, control and SA birds were inoculated with PBS or Salmonella Typhimurium, respectively. Five SA birds were transferred to SN cages to facilitate natural infection. Cecal content and blood samples were collected at 0, 8, 14, and 21 days of age for microbiota and leukocyte analysis, respectively. A significant change in microbiota composition was observed in both groups as noted by a decrease in Lactobacillus and Escherichia and an increase in Bacteroides. Leukocyte analysis revealed a decrease in the percentage of circulating monocytes at 7 days post-infection while a decrease in thrombocyte and an increase in heterophil percentages were seen at 14 days post-infection. Taken together, these results demonstrate the ability of Salmonella to modulate the intestinal microbiota to facilitate colonization. Additionally, results indicated an early role of monocytes and thrombocytes during colonization, followed by heterophils.

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“…The antibodies of CS repeats, on the other hand, eliminate sporozoites via different mechanisms such as, firstly, cytotoxicity as a result of complement cascade activation. The cascade can be activated to attract and enhance innate immune cells’ phagocytosis, which leads to the destruction of the target cells and shields the host from infection and inflammation [ 50 , 60 – 62 ]. Secondly, direct neutralization of sporozoites to prevent cell penetration and migration [ 50 , 63 ].…”

Section: Pathogenesis and Pathophysiology Of Malariamentioning

confidence: 99%

Current advances in nanodrug delivery systems for malaria prevention and treatment

Kekani

Witika

2023

Discover Nano

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Malaria is a life-threatening, blood-borne disease with over two hundred million cases throughout the world and is more prevalent in Sub-Saharan Africa than anywhere else in the world. Over the years, several treatment agents have been developed for malaria; however, most of these active pharmaceutical ingredients exhibit poor aqueous solubility and low bioavailability and may result in drug-resistant parasites, thus increasing malaria cases and eventually, deaths. Factors such as these in therapeutics have led to a better appreciation of nanomaterials. The ability of nanomaterials to function as drug carriers with a high loading capacity and targeted drug delivery, good biocompatibility, and low toxicity renders them an appealing alternative to conventional therapy. Nanomaterials such as dendrimers and liposomes have been demonstrated to be capable of enhancing the efficacy of antimalarial drugs. This review discusses the recent development of nanomaterials and their benefits in drug delivery for the potential treatment of malaria.

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Thrombocyte functions in the avian immune system

Cited by 3 publications

References 45 publications

The Immunological Capacity of Thrombocytes

The Immunological Capacity of Thrombocytes

Effect of Salmonella Typhimurium Colonization on Microbiota Maturation and Blood Leukocyte Populations in Broiler Chickens

Current advances in nanodrug delivery systems for malaria prevention and treatment

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