Thrombin receptor agonist peptide immobilized in microspheres stimulates reparative processes in rats with gastric ulcer

Rusanova, A. V.; Makarova, Anastasia A.; Strukova, S. M.; Марквичева, Елена; Gorbachyova, L. R.; Stashevskaya, K; Васильева, Т. В.; Sidorova, E.; Bespalova, Zh. D.; Grandfils, Christian

doi:10.1007/s10517-006-0285-y

Cited by 8 publications

(4 citation statements)

References 8 publications

(10 reference statements)

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“…PAR 1 has been described in Th 2 -mediated colitis [95]. It is also interesting to notice that the microspheres with an encapsulated PAR 1 -AP accelerated the healing process of experimental ulcers in rats [127].…”

Section: Pars and Inflammatory Gastrointestinal Diseasesmentioning

confidence: 93%

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

Shpacovitch

Feld

Hollenberg

et al. 2008

Journal of Leukocyte Biology

171

135

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Serine proteases are well known as enzymes involved in digestion of dietary proteins, blood coagulation, and homeostasis. Only recent groundbreaking studies revealed a novel role of serine proteases as signaling molecules acting via protease-activated receptors (PARs). Important effects of PAR activation on leukocyte motility, cytokine production, adhesion molecule expression, and a variety of other physiological or pathophysiological functions have been described in vitro and in vivo. The crucial role of PAR activation during disease progression was revealed in animal models of different gastrointestinal pathologies, neuroinflammatory and neurodegenerative processes, skin, joint and airway inflammation, or allergic responses. This review focuses on the findings related to the impact of PAR deficiency in animal models of inflammatory and allergic diseases. Additionally, we observe the role of PAR activation in the regulation of functional responses of innate and adaptive immune cells in vitro. Understanding the mechanisms by which PARs exert the effects of serine proteases on immune cells may lead to new therapeutic strategies in inflammation, immune defense, and allergy.

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Section: Pars and Inflammatory Gastrointestinal Diseasesmentioning

confidence: 93%

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

Shpacovitch

Feld

Hollenberg

et al. 2008

Journal of Leukocyte Biology

171

135

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“…145 Scientists have also coated non-degradable implants with heparin and synthetic thrombin receptor agonist to shorten the inflammatory FBR, since they functions to bind to regulators of coagulation and complement activation. 80,146–153 Also, anti-inflammatory coatings previously reported to reduce neutrophil recruitment and FBR upon implantation of non-biodegradable implants include superoxide dismutase mimetics, 154 interleukin-1 receptor antagonist, 155 curcumin, 156–158 and vitamin E. 159 …”

Section: Efforts To Mitigate Fbrmentioning

confidence: 99%

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini

Wallace

Nukavarapu

2011

J Long Term Eff Med Implants

140

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Presently, orthopedic and oral/maxillofacial implants represent a combined $2.8 billion market, a figure expected to experience significant and continued growth. Although traditional permanent implants have been proved clinically efficacious, they are also associated with several drawbacks, including secondary revision and removal surgeries. Non-permanent, biodegradable implants offer a promising alternative for patients, as they provide temporary support and degrade at a rate matching tissue formation, and thus, eliminate the need for secondary surgeries. These implants have been in clinical use for nearly 25 years, competing directly with, or maybe even exceeding, the performance of permanent implants. The initial implantation of biodegradable materials, as with permanent materials, mounts an acute host inflammatory response. Over time, the implant degradation profile and possible degradation product toxicity mediate long-term biodegradable implant-induced inflammation. However, unlike permanent implants, this inflammation is likely to cease once the material disappears. Implant-mediated inflammation is a critical determinant for implant success. Thus, for the development of a proactive biodegradable implant that has the ability to promote optimal bone regeneration and minimal detrimental inflammation, a thorough understanding of short- and long-term inflammatory events is required. Here, we discuss an array of biodegradable orthopedic implants, their associated short- and long- term inflammatory effects, and methods to mediate these inflammatory events.

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“…135 Synthetic thrombin receptor (PAR1) agonist peptide encapsulated in biodegradable microspheres shortened the inflammatory phase and accelerated tissue healing in a rat ulcer model. 136 Short half-lives and requirements for high dosing frequencies limit the use of therapeutic proteins; however, PEGylation strategies have been investigated as a potential approach to extend the therapeutic lifetime of molecules such as IL-1Ra. 137 Using layer-by-layer deposition techniques, Pierstorff et al have developed a copolymer nanofilm system as a multifunctional platform to release a variety of antiinflammatory drugs; additionally, it may be possible to functionalize these agents onto implant surfaces to enhance delivery specificity over traditional systemic drug administration.…”

Section: Active Strategies: Delivery Of Anti-inflammatory Agentsmentioning

confidence: 99%

Anti-Inflammatory Polymeric Coatings for Implantable Biomaterials and Devices

Bridges

Garcı́a

2008

J Diabetes Sci Technol

160

132

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Synthetic polymer coatings are used extensively in modern medical devices and implants because of their material versatility and processability. These coatings are designed for specific applications by controlling composition and physical and chemical properties, and they can be formed into a variety of complex structures and shapes. However, implantation of these materials into the body elicits a strong inflammatory host response that significantly limits the integration and biological performance of devices. Biomaterial-mediated inflammation is a complex reaction involving protein adsorption, leukocyte recruitment and activation, secretion of inflammatory mediators, and fibrous encapsulation of the implant. Significant research efforts have focused on modifying material properties using various anti-inflammatory polymeric surface coatings to generate more biocompatible implants. This minireview provides a brief background on the events of biomaterial-mediated inflammation and highlights various approaches used for modifying material surfaces to modulate inflammatory responses. These include both passive and active strategies, such as nonfouling surface treatments and delivery of anti-inflammatory agents, respectively. Novel approaches will be needed to extend the in vivo lifetime and performance of devices and reduce the need for multiple implantation surgeries.

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Thrombin receptor agonist peptide immobilized in microspheres stimulates reparative processes in rats with gastric ulcer

Cited by 8 publications

References 8 publications

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Anti-Inflammatory Polymeric Coatings for Implantable Biomaterials and Devices

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