Thrombin generation potential is increased in patients with autoimmune inflammatory myopathies

Kuszmiersz, Piotr; Siwiec-Koźlik, Andżelika; Pacholczak-Madej, Renata; Rams, Anna; Celińska-Löwenhoff, Magdalena; Iwaniec, Teresa; Kosałka-Węgiel, Joanna; Zaręba, Lech; Dziedzic, Radosław; Bazan-Socha, Stanisława; Dropiński, Jerzy

doi:10.1016/j.advms.2022.08.005

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Our results mirror previously published data on increased thrombin generation in other chronic inflammatory diseases, such as asthma 35 , rheumatoid arthritis 36 , systemic sclerosis 37 , systemic lupus erythematosus 33 and autoimmune inflammatory myopathies 38 . They all point to the complex nature of the coagulation pathway control; however, inflammation and endothelial damage were essential factors associated with the prothrombotic state in most of them.…”

Section: Discussionsupporting

confidence: 91%

Prothrombotic state, endothelial injury, and echocardiographic changes in non-active sarcoidosis patients

Siwiec-Koźlik

Kuszmiersz

Kasper

et al. 2022

Sci Rep

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Sarcoidosis is a multisystem inflammatory granulomatous disease of unknown cause that most commonly affects lungs and lymph nodes, with frequent yet asymptomatic cardiac involvement. The epidemiologically associated cardiovascular risk suggests an underlying prothrombotic state and endothelial dysfunction, currently understudied in the available literature. Therefore, we aimed to investigate prothrombotic plasma properties together with selected echocardiographic and laboratory biomarkers of cardiovascular injury in that disease. N = 53 patients with pulmonary sarcoidosis in clinical remission and N = 66 matched controls were assessed for inflammatory and endothelial injury biomarkers, plasma thrombin generation profile, and echocardiographic and lung function parameters. Sarcoidosis cases had impaired systolic and diastolic left ventricular function, higher concentrations of inflammatory markers, D-dimer and factor VIII activity compared to the controls. The coexistence of extrapulmonary disease was associated with elevated circulating vascular cell adhesion molecule 1, while cases with hypercalcemia had higher thrombomodulin concentration. Sarcoidosis was characterized by the unfavorably altered thrombin generation profile, reflected by the 16% higher endogenous thrombin potential (ETP), 24% increased peak thrombin concentration, and 12% shorter time to thrombin peak in comparison to the control group. ETP was higher in cases with proxies of pulmonary restriction, extrapulmonary–extracutaneous manifestation, and need for corticosteroids use. Despite the clinical remission, sarcoidosis is related to prothrombotic plasma properties and signs of endothelial injury, likely contributing to the higher risk of cardiovascular events. In addition, subclinical cardiac involvement may play an additional role, although further clinical and experimental studies are needed to verify these findings.

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Section: Discussionsupporting

confidence: 91%

Prothrombotic state, endothelial injury, and echocardiographic changes in non-active sarcoidosis patients

Siwiec-Koźlik

Kuszmiersz

Kasper

et al. 2022

Sci Rep

Self Cite

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“…Patients with IIM are no exception, with several studies having reported a significantly increased risk of venous thromboembolism in patients with DM/PM [ 34 , 39 – 42 ]. An enhanced in vitro thrombin generation profile in patients with DM/PM has been demonstrated, which may correlate to an increased risk of thromboembolic events [ 43 ]. Carruthers et al reported an eight- and six-fold higher risk of developing venous thromboembolism in patients with DM and PM respectively.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular manifestations in idiopathic inflammatory myopathies

et al. 2023

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Cardiovascular involvement in idiopathic inflammatory myopathies (IIM) is an understudied area which is gaining increasing recognition in recent times. Recent advances in imaging modalities and biomarkers have allowed the detection of subclinical cardiovascular manifestations in IIM. However, despite the availability of these tools, the diagnostic challenges and underestimated prevalence of cardiovascular involvement in these patients remain significant. Notably, cardiovascular involvement remains one of the leading causes of mortality in patients with IIM. In this narrative literature review, we outline the prevalence and characteristics of cardiovascular involvement in IIM. Additionally, we explore investigational modalities for early detection of cardiovascular involvement, as well as newer approaches in screening to facilitate timely management. Key points• Cardiac involvement in IIM in majority cases is subclinical and a major cause of mortality.• Cardiac magnetic resonance imaging is sensitive for detection of subclinical cardiac involvement.

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Polymyositis and dermatomyositis biomarkers

Hu²,

Wang

et al. 2023

Clinica Chimica Acta

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Thrombin generation potential is increased in patients with autoimmune inflammatory myopathies

Cited by 4 publications

References 39 publications

Prothrombotic state, endothelial injury, and echocardiographic changes in non-active sarcoidosis patients

Prothrombotic state, endothelial injury, and echocardiographic changes in non-active sarcoidosis patients

Cardiovascular manifestations in idiopathic inflammatory myopathies

Polymyositis and dermatomyositis biomarkers

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