Thrombin Generation in Normal Subjects and Cardiac Patients

Abstract

Reagents1) Sodium citrate, USP, 3.8%. 2) 0.5 M calcium chloride. 3) Buffered saline, pH 7.42, consisting of four parts 0.85% sodium chloride and one part

Effect of moderate exercise on the fibrinolytic system in normal young men and women.

“…We postulate that it may represent, in part, the ability of the individual to generate circulating plasminogen activator to stress. Exercise has also been shown to increase the coagulability of the blood (Vuori, 1950;Bond et al, 1961 ;Iatridis and Ferguson, 1963 ;Burt et al, 1964;von Kaulla and von Kaulla, 1964). Thus, on the basis of a dynamic equilibrium between coagulation and fibrinolysis, an increase in fibrinolysis would be anticipated.…”

“…We believe that the study of coagulation and fibrinolysis, simultaneously, before and after exercise may prove to be a more relevant focusing-point for observing potential states of coagulation-fibrinolysis disequilibrium than a measurement of these values in the resting state, as has been the practice in the past (Hume, 1958 ;Lackner and Merskey, 1960;Nestel, 1960;Ogston, 1962;Katz et al, 1963 ;Naimi et al, 1963 ;MacKay and Hume, 1964;Chakrabarti et al, 1966).…”

Influence of Spinal and General Anaesthesia on Haemostasis During Total Hip Arthroplasty

“…These differences included an absence of the immediate postoperative increase in FVIIIRAg activity, minimal change in platelet count and less activation of fibrinolysis in the SAB group compared with the GA group. The perioperative reduction in thrombin generation index in the SAB group was significant, especially since some workers (von Kaulla and von Kaulla, 1964;Zuck and Bergin, 1973;Peck, 1979) consider this laborious test, which is a non-specific but sensitive measure of the coagulation system, to be valuable in the identification of the hypercoagulable state. The differences between the two anaesthetic groups in these variables, but not in PTT and PTTK, suggest only a minor modulation of the haemostatic response by spinal anaesthesia compared with general anaesthesia.…”

Changes in Blood Clotting Systems During Migraine Attacks

“…The thrombin generation test which reflects the amount and speed with which thrombin is formed. 7 The ethanol gelation test. Plasma containing soluble fibrin is gelled by ethanol at room temperature.…”