Thrombin generation during cardiac bypass surgery

Duff, E.; Billing, Valerie; McPherson, Duncan; Coakley, M.; Collins, Peter William; Hall, Jeff

doi:10.1111/j.1365-2044.2008.05644_2.x

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2011

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“…Similar to our results, Tanaka et al 30 demonstrated a reduced thrombin generation compared with prebypass values by using the Thrombin Generation and Cardiac Surgery method described by Hemker et al, 45 which was also confirmed by others. 32,52 The postoperative period has not yet been investigated. In our patients, high TDT values and a weak but positive correlation between prothrombin fragment F 1ϩ2 levels and TDT on the first POD suggest that although ongoing thrombin generation is observed, the capacity of the plasma to generate thrombin remains.…”

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confidence: 99%