Thresholds for perception of direction of linear acceleration as a possible evaluation of the otolith function

Kingma, Herman

doi:10.1186/1472-6815-5-5

Cited by 73 publications

(70 citation statements)

References 10 publications

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“…However, these studies have not provided two important details: possible effects of aging and possible directional asymmetries. Prior work in the field has focused on a young population that almost never included subjects beyond the age of 40, even though it has been shown that age does effect perception of steady-state translation (Kingma 2005). Because the prevalence of vestibular disorders is much higher after the age of 50 (Agrawal et al 2009), there is a need for normative data in older individuals.…”

Section: Discussionmentioning

confidence: 99%

“…In comparing cervical (cVEMP) and ocular (oVEMP) results between subjects in their twenties and those older than 50, the amplitude of both responses was decreased by half in the older group. Perception of sinusoids in surge has been shown to decline with age, but no effect of age was seen with lateral motion (Kingma 2005). These prior axis dependent effects have been difficult to interpret because the thresholds found by Kingma et al were significantly lower than those found by others (Benson et al 1986;Gianna et al 1996).…”

Section: The Effect Of Agingmentioning

confidence: 91%

“…Vestibular reflexes including the VOR (Stefansson and Imoto 1986;Tian et al 2001), spinal reflexes (Liaw et al 2009), and VEMP (Nguyen et al 2010) also decline with age. Most prior studies of motion perception have focused on a population under age 40 (Walsh 1961;Benson et al 1986Grabherr et al 2008;MacNeilage et al 2010;Mallery et al 2010;Soyka et al 2011), but when older subjects were included, advanced age was associated with higher perceptual thresholds in fore-aft motion (Kingma 2005).…”

Section: Introductionmentioning

confidence: 99%

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Directional Asymmetries and Age Effects in Human Self-Motion Perception

Roditi

Crane

2012

JARO

109

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Directional asymmetries in vestibular reflexes have aided the diagnosis of vestibular lesions; however, potential asymmetries in vestibular perception have not been well defined. This investigation sought to measure potential asymmetries in human vestibular perception. Vestibular perception thresholds were measured in 24 healthy human subjects between the ages of 21 and 68 years. Stimuli consisted of a single cycle of sinusoidal acceleration in a single direction lasting 1 or 2 s (1 or 0.5 Hz), delivered in sway (leftright), surge (forward-backward), heave (up-down), or yaw rotation. Subject identified self-motion directions were analyzed using a forced choice technique, which permitted thresholds to be independently determined for each direction. Non-motion stimuli were presented to measure possible response bias. A significant directional asymmetry in the dynamic response occurred in 27% of conditions tested within subjects, and in at least one type of motion in 92% of subjects. Directional asymmetries were usually consistent when retested in the same subject but did not occur consistently in one direction across the population with the exception of heave at 0.5 Hz. Responses during null stimuli presentation suggested that asymmetries were not due to biased guessing. Multiple models were applied and compared to determine if sensitivities were direction specific. Using Akaike information criterion, it was found that the model with direction specific sensitivities better described the data in 86% of runs when compared with a model that used the same sensitivity for both directions. Mean thresholds for yaw were 1.3±0.9°/s at 0.5 Hz and 0.9±0.7°/s at 1 Hz and were independent of age. Thresholds for surge and sway were 1.7±0.8 cm/s at 0.5 Hz and 0.7±0.3 cm/s at 1.0 Hz for subjects G50 and were significantly higher in subjects 950 years old. Heave thresholds were higher and were independent of age.

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Section: Discussionmentioning

confidence: 99%

Section: The Effect Of Agingmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Directional Asymmetries and Age Effects in Human Self-Motion Perception

Roditi

Crane

2012

JARO

109

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“…1C). For inertial motion, these accelerations far exceed vestibular thresholds (for review, see Gundry, 1978) (Benson et al, 1986;Kingma, 2005).…”

Section: Methodsmentioning

confidence: 99%

Visual and Nonvisual Contributions to Three-Dimensional Heading Selectivity in the Medial Superior Temporal Area

Gu¹,

Watkins²,

Angelaki³

et al. 2006

J. Neurosci.

287

626

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Robust perception of self-motion requires integration of visual motion signals with nonvisual cues. Neurons in the dorsal subdivision of the medial superior temporal area (MSTd) may be involved in this sensory integration, because they respond selectively to global patterns of optic flow, as well as translational motion in darkness. Using a virtual-reality system, we have characterized the three-dimensional (3D) tuning of MSTd neurons to heading directions defined by optic flow alone, inertial motion alone, and congruent combinations of the two cues. Among 255 MSTd neurons, 98% exhibited significant 3D heading tuning in response to optic flow, whereas 64% were selective for heading defined by inertial motion. Heading preferences for visual and inertial motion could be aligned but were just as frequently opposite. Moreover, heading selectivity in response to congruent visual/vestibular stimulation was typically weaker than that obtained using optic flow alone, and heading preferences under congruent stimulation were dominated by the visual input. Thus, MSTd neurons generally did not integrate visual and nonvisual cues to achieve better heading selectivity. A simple two-layer neural network, which received eye-centered visual inputs and head-centered vestibular inputs, reproduced the major features of the MSTd data. The network was trained to compute heading in a head-centered reference frame under all stimulus conditions, such that it performed a selective reference-frame transformation of visual, but not vestibular, signals. The similarity between network hidden units and MSTd neurons suggests that MSTd may be an early stage of sensory convergence involved in transforming optic flow information into a (head-centered) reference frame that facilitates integration with vestibular signals.

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“…Alternative methods of testing otolith function are being investigated and validated, including assays based on linear motion perceptual thresholds similar to auditory threshold testing (Kingma 2005;MacNeilage et al 2010a;Merfeld 2011;Roditi and Crane 2012;Valko et al 2012). Motion perceptual threshold testing is a promising vestibular testing modality given that the stimuli (head translations or rotations) are physiological and thus test performance may better correlate with symptoms and functional status relative to VEMP testing (Merfeld et al 2010).…”

mentioning

confidence: 99%

Clinical Testing of Otolith Function: Perceptual Thresholds and Myogenic Potentials

Agrawal

Bremova-Ertl

Kremmyda

et al. 2013

JARO

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Cervical and ocular vestibular-evoked myogenic potential (cVEMP/oVEMP) tests are widely used clinical tests of otolith function. However, VEMP testing may not be the ideal measure of otolith function given the significant inter-individual variability in responses and given that the stimuli used to elicit VEMPs are not physiological. We therefore evaluated linear motion perceptual threshold testing compared with cVEMP and oVEMP testing as measures of saccular and utricular function, respectively. A multi-axis motion platform was used to measure horizontal (along the inter-aural and nasooccipital axes) and vertical motion perceptual thresholds. These findings were compared with the vibration-evoked oVEMP as a measure of utricular function and soundevoked cVEMP as a measure of saccular function. We also considered how perceptual threshold and cVEMP/ oVEMP testing are each associated with Dizziness Handicap Inventory (DHI) scores. We enrolled 33 patients with bilateral vestibulopathy of different severities and 42 controls to have sufficient variability in otolith function. Subjects with abnormal oVEMP amplitudes had significantly higher (poorer) perceptual thresholds in the inter-aural and naso-occipital axes in age-adjusted analyses; no significant associations were observed for vertical perceptual thresholds and cVEMP amplitudes.Both oVEMP amplitudes and naso-occipital axis perceptual thresholds were significantly associated with DHI scores. These data suggest that horizontal perceptual thresholds and oVEMPs may estimate the same underlying physiological construct: utricular function.

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Thresholds for perception of direction of linear acceleration as a possible evaluation of the otolith function

Cited by 73 publications

References 10 publications

Directional Asymmetries and Age Effects in Human Self-Motion Perception

Directional Asymmetries and Age Effects in Human Self-Motion Perception

Visual and Nonvisual Contributions to Three-Dimensional Heading Selectivity in the Medial Superior Temporal Area

Clinical Testing of Otolith Function: Perceptual Thresholds and Myogenic Potentials

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