Thresholds for cavitation produced in water by pulsed ultrasound

Atchley, Anthony A.; Frizzell, Leon A.; Apfel, Robert E.; Holland, Christy K.; Madanshetty, Sameer I.; Roy, Ronald A.

doi:10.1016/0041-624x(88)90018-2

Cited by 130 publications

(74 citation statements)

References 8 publications

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“…Cavitation thresholds for UCAs have been shown to decrease with an increase in ultrasound pulse duration for pulses of 10 or fewer cycles (Atchley et al, 1988;Chen et al, 2003). However, Giesecke and Hynynen (2003) showed no change in the inertial cavitation thresholds for longer pulse durations (20-100 ms).…”

Section: DC Dependencementioning

confidence: 96%

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Gruber

Bader

Holland

2014

The Journal of the Acoustical Society of America

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Ultrasound contrast agents (UCAs) can be employed to nucleate cavitation to achieve desired bioeffects, such as thrombolysis, in therapeutic ultrasound applications. Effective methods of enhancing thrombolysis with ultrasound have been examined at low frequencies (<1 MHz) and low amplitudes (<0.5 MPa). The objective of this study was to determine cavitation thresholds for two UCAs exposed to 120-kHz ultrasound. A commercial ultrasound contrast agent (Definity V R ) and echogenic liposomes were investigated to determine the acoustic pressure threshold for ultraharmonic (UH) and broadband (BB) generation using an in vitro flow model perfused with human plasma. Cavitation emissions were detected using two passive receivers over a narrow frequency bandwidth (540-900 kHz) and a broad frequency bandwidth (0.54-1.74 MHz). UH and BB cavitation thresholds occurred at the same acoustic pressure (0.3 6 0.1 MPa, peak to peak) and were found to depend on the sensitivity of the cavitation detector but not on the nucleating contrast agent or ultrasound duty cycle.

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Section: DC Dependencementioning

confidence: 96%

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Gruber

Bader

Holland

2014

The Journal of the Acoustical Society of America

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“…Focused PCDs provide high sensitivity and spatial specificity in the focal region but are insensitive outside the focal region. 18,27 Unfocused PCDs can record cavitation emissions over a large area but have decreased sensitivity and spatial specificity. 28,29 More recently, PCDs using multiple-element arrays have been shown to reduce the limitations of focused and unfocused PCDs by allowing for spatial resolution over a large area.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Current research focuses on increasing efficacy and illuminating the specific mechanisms by which acoustic cavitation induces a bioeffect. Many passive and active cavitation detection techniques [17][18][19] have been developed to monitor acoustic cavitation.…”

Section: Introductionmentioning

confidence: 99%

Passive imaging with pulsed ultrasound insonations

Haworth¹,

Mast²,

Radhakrishnan³

et al. 2012

The Journal of the Acoustical Society of America

110

138

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Previously, passive cavitation imaging has been described in the context of continuous-wave high-intensity focused ultrasound thermal ablation. However, the technique has potential use as a feedback mechanism for pulsed-wave therapies, such as ultrasound-mediated drug delivery. In this paper, results of experiments and simulations are reported to demonstrate the feasibility of passive cavitation imaging using pulsed ultrasound insonations and how the images depend on pulsed ultrasound parameters. The passive cavitation images were formed from channel data that was beamformed in the frequency domain. Experiments were performed in an in vitro flow phantom with an experimental echo contrast agent, echogenic liposomes, as cavitation nuclei. It was found that the pulse duration and envelope have minimal impact on the image resolution achieved. The passive cavitation image amplitude scales linearly with the cavitation emission energy. Cavitation images for both stable and inertial cavitation can be obtained from the same received data set.

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“…Acoustic cavitation is the formation and collapse of gaseous and vapor bubbles in a liquid due to an acoustic pressure field [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Cavitation is generally classified into two types: stable cavitation, which results in acoustic emissions at sub-harmonics of the fundamental frequency and associated ultra-harmonics, and inertial cavitation, which is characterized by broadband acoustic emissions.…”

Section: Us Technology For Therapeutic Delivery and Monitoringmentioning

confidence: 99%

Ultrasound-Mediated Drug Delivery for Cardiovascular Disease

Holland

2017

Ultrasound in Medicine & Biology

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Introduction-Ultrasound (US) has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. These effects can be mediated by mechanical oscillations of circulating microbubbles, or US contrast agents, which may also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid effects that effect drug penetration into vascular tissue, lyse thrombi or direct drugs to optimal locations for delivery.Areas covered-The present review summarizes investigations that have provided evidence for US-mediated drug delivery as a potent method to deliver therapeutics to diseased tissue for cardiovascular treatment. In particular, the focus will be on investigations of specific aspects relating to US-mediated drug delivery, such as delivery vehicles, drug transport routes, biochemical mechanisms and molecular targeting strategies.Expert opinion-These investigations have spurred continued research into alternative therapeutic applications, such as bioactive gas delivery and new US technologies. Successful implementation of US-mediated drug delivery has the potential to change the way many drugs are administered systemically, resulting in more effective and economical therapeutics, and lessinvasive treatments.

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Thresholds for cavitation produced in water by pulsed ultrasound

Cited by 130 publications

References 8 publications

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Passive imaging with pulsed ultrasound insonations

Ultrasound-Mediated Drug Delivery for Cardiovascular Disease

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