Threshold increases in plasma growth hormone in relation to plasma catecholamine and blood lactate concentrations during progressive exercise in endurance-trained athletes

Chwalbińska-Moneta, J; Krysztofiak, F; Ziemba, Andrzej; Nazar, K; Kaciuba-Uściłko, H.

doi:10.1007/bf00262819

Cited by 50 publications

(35 citation statements)

References 21 publications

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“…Previous research has suggested that exercise intensity plays a key role, wherein a particular threshold of exercise intensity must be exceeded to elicit GH release (3)(4)(5). However, recent data from our laboratory indicate that, in young men, the magnitude of GH release rises with increasing exercise intensity in a linear doseresponse relationship (as opposed to a threshold relationship) (20).…”

contrasting

confidence: 41%

Gender governs the relationship between exercise intensity and growth hormone release in young adults

Pritzlaff-Roy¹,

Widemen²,

Weltman³

et al. 2002

Journal of Applied Physiology

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We previously reported that in young adult males growth hormone (GH) release is related to exercise intensity in a linear dose-response manner (Pritzlaff et al. J Appl Physiol 87: 498-504, 1999). To investigate the effects of gender and exercise intensity on GH release, eight women (24.3 Ϯ 1.3 yr, 171 Ϯ 3.2 cm height, 63.6 Ϯ 8.7 kg weight) were each tested on six randomly ordered occasions [1 control condition (C), 5 exercise conditions (Ex)]. Serum GH concentrations were measured in samples obtained at 10-min intervals between 0700 and 0900 (baseline) and 0900 and 1300 (Ex ϩ recovery or C). Integrated GH concentrations (IGHC) were calculated by trapezoidal reconstruction. During Ex, subjects exercised for 30 min (0900-0930) at one of the following intensities [normalized to the lactate threshold (LT)]: 25 and 75% of the difference between LT and rest, at LT, and at 25 and 75% of the difference between LT and peak O2 uptake. No differences were observed among conditions for baseline IGHC. To determine whether total (Ex ϩ recovery) IGHC changed with increasing exercise intensity, slopes associated with individual linear regression models were subjected to a Wilcoxon signed-rank test. To test for gender differences, data in women were compared with the previously published data in men. A Wilcoxon ranked-sums two-tailed test was used to analyze the slopes and intercepts from the regression models. Total IGHC increased linearly with increasing exercise intensity. The slope and intercept values for the relationship between total IGHC and exercise intensity were greater in women than in men. Deconvolution analysis (0700-1300 h) revealed that, regardless of gender, increasing exercise intensity resulted in a linear increase in the mass of GH secreted per pulse and summed GH production rate, with no changes in GH secretory pulse frequency or apparent half-life of elimination. Exercise reduced the half-duration of GH secretory burst in men but not in women. Gender comparisons revealed that women had greater basal (nonpulsatile) GH secretion across all conditions, more frequent GH secretory pulses, a greater GH secretory pulse amplitude, a greater production rate, and a trend for a greater mass of GH secreted per pulse than men. We conclude that, in young adults, the GH secretory response to exercise is related to exercise intensity in a linear dose-response pattern. For each incremental increase in exercise intensity, the fractional stimulation of GH secretion is greater in women than in men. male; female; lactate threshold; endocrinology; pituitary; somatotropin ACUTE EXERCISE IS A POWERFUL stimulus to growth hormone (GH) release (2-5, 15, 17, 20, 32, 33). Previous research has suggested that exercise intensity plays a key role, wherein a particular threshold of exercise intensity must be exceeded to elicit GH release (3-5). However, recent data from our laboratory indicate that, in young men, the magnitude of GH release rises with increasing exercise intensity in a linear doseresponse relationship (as opposed to a thre...

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contrasting

confidence: 41%

Gender governs the relationship between exercise intensity and growth hormone release in young adults

Pritzlaff-Roy¹,

Widemen²,

Weltman³

et al. 2002

Journal of Applied Physiology

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“…During and after exercise, there are a number of potential stimuli for GH release (lactate, hydrogen ion, catecholamines, core temperature), but the factors that determine the magnitude of GH release remain unclear. Some research have suggested a stimulatory effect of lactic acid on GH release (Chwalbinska-Moneta et al 1996;Langfort et al2001). However, other studies (Kozlowski et al 1983;Zoladz et al 2002) found no causal relationship between blood lactate and GH.…”

Section: Discussionmentioning

confidence: 98%

Effect of training on GH and IGF-1 responses to a submaximal exercise in football players

et al. 2005

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To study the effects of regular football training on basal and exercise induced levels of growth hormone (GH) and insulin-like growth factor (IGF-1), 13 young football players were investigated by a submaximal exercise at the beginning of the sporting season in October (S1), at the middle of the season in January (S2) and at the end in May (S3). At each session, an exercise test on an ergogycle was performed for 25 min, beginning with an incremental exercise to reach 90% of theoretical maximal heart, which was maintained for the last 10 min of the test. Venous blood samples were collected at rest, at the end of the exercise and at 30 and 60 min during the recovery period. Plasma lactate and glucose concentrations increased during exercise with no difference found between sessions. GH level increased with exercise at each session but the response was significantly higher in S1 than in S2 and S3 (P<0.01). The GH area under the curve decreased significantly all along the football season (P<0.01); the IGF-1 level did not significantly change during exercise nor with training. Basal insulin-like growth factor binding protein-3 (IGFBP3) remained stable during the three sessions. Football training decreased significantly the exercise-stimulated GH levels all along the football season but did not have any significant effect on IGF-1 levels or on basal IGFBP3 levels.

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“…Furthermore, a strong correlation has been observed between the plasma catecholamine and lactate levels during incremental exercise [26]. The stress produced in rats that are forced to run on a treadmill might produce a lot of catecholamine, and as a result the blood lactate concentration could increase even under relatively lowlevel exercise.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Lactate Threshold During Treadmill Exercise After Microsphere-Induced Infarction in Rats

Takahashi¹,

Himi²,

Kuniyasu³

et al. 2012

Journal of Stroke and Cerebrovascular Diseases

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Objectives The aim of this study was to clarify changes in the lactate threshold (LT) in the acute period after cerebral infarction.Methods Cerebral infarction was induced by the injection of microspheres (MS) into the right internal carotid artery. To estimate the degree of neurological deficit caused by surgery, the behaviors of all rats were evaluated in terms of typical symptoms of stroke in rats. A rotarod test was used to evaluate equilibrium function. Rats were forced to perform stepwise treadmill exercises and serial changes in the blood lactate concentration were measured for determination of the LT. ResultsThe average treadmill speed at the LT and rotarod performance in MS rats was significantly lower than those in sham-operated rats on the 2 nd days after surgery.However, while neurological deficits disappeared on the 7 th days after surgery in MS rats, the LT and rotarod performance were significantly lower than those in shamoperated rats. ConclusionThese results suggest that the decrease in the LT in the acute period following cerebral infarction may be induced by impairment of the equilibrium function.Other possibilities are also discussed.

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Threshold increases in plasma growth hormone in relation to plasma catecholamine and blood lactate concentrations during progressive exercise in endurance-trained athletes

Cited by 50 publications

References 21 publications

Gender governs the relationship between exercise intensity and growth hormone release in young adults

Gender governs the relationship between exercise intensity and growth hormone release in young adults

Effect of training on GH and IGF-1 responses to a submaximal exercise in football players

Changes in the Lactate Threshold During Treadmill Exercise After Microsphere-Induced Infarction in Rats

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