“…The larger the area treated, the greater is the tissue damage from backscatter (allowance for which must be made in computing dosage) and the greater is the tissue injury effect, a phenomenon which also delays and disturbs healing (Belisario, 1942(Belisario, , 1951. Also the cosmetic effect in general (within therapeutic Mmits) is improved in proportion to the greater fractionation of the dose of radiation.…”