Three Years' Experience With the Biological Agent Denosumab Used to Treat Women With Postmenopausal Osteoporosis: Efficacy, Safety and Treatment Adherence

Торопцова, Н. В.; Никитинская, О. А.; Смирнов, А. В.

doi:10.14412/1995-4484-2017-261-266

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Препарат показан для лечения остеопороза, при этом в литературе отсутствуют сообщения о связи деносумаба и синдрома ЛВ, а также о взаимодействии деносумаба с иФНОα [61]. Данные, касающиеся деносумаба, в основном демонстрируют его эффективность и безопасность при лечении больных с постменопаузальным остеопорозом, при этом нет указаний на случаи развития синдрома ЛВ [62,63].…”

Section: с р а в н и т е л ь н а я х а р а к т е р и с т и к а и д и unclassified

Drug-induced lupus

Клюквина¹,

Гунчикова

Aa³

2018

Sovremennaâ revmatologiâ

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Drug-induced lupus (DIL) is an autoimmune phenomenon that has similar clinical and laboratory manifestations with idiopathic systemic lupus erythematosus (SLE). About 100 drugs are now known to be associated with the development of DIL. Its diagnosis is verified in the presence of a chronological relationship between the long-term administration of drugs and the mandatory presence of one clinical and one laboratory diagnostic criteria for SLE.The paper deals with the etiology, pathogenesis, and differential diagnosis of DIL. It presents a spectrum of drugs that can cause DIL and considers the features of its different forms.Based on the recent data available in the literature, the authors analyze the occurrence of autoimmune responses due to the useof biologic agents (BAs), primarily tumor necrosis factor-αinhibitors. Therapeutic approaches for DIL are discussed. Recommendations are given for screening the patients in the use of BAs. Clinical examples are provided.

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Section: с р а в н и т е л ь н а я х а р а к т е р и с т и к а и д и unclassified

Drug-induced lupus

Клюквина¹,

Гунчикова

Aa³

2018

Sovremennaâ revmatologiâ

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Steroid osteoporosis within the framework of the Itsenko-Cushing drug syndrome: demonstration of a clinical case

Fleyshman

Belyaeva

2021

Clinical Medicine and Pharmacology

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A case of severe systemic osteoporosis complicated by multiple fractures of the ribs and vertebrae in a young patient with late diagnosis of Still's disease as a result of independent long-term uncontrolled use of corticosteroids is presented. Lack of medical supervision, taking a high dose (35 mg / day) of prednisolone without recommendation and control of treatment led to untimely recognition and treatment of the underlying disease and the development of irreversible disabling transformations of the skeleton.

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Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement

Торопцова¹

2018

Sovremennaâ revmatologiâ

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Osteoporosis is a chronic disease requiring long-term treatment aimed at reducing the risk of low-energy fractures, by improving the quality and strength of bones when taking this or that drug. Bisphosphonates (BPs) are deposited in the bone, so that they have an aftereffect. Due to the increased risk of adverse reactions with BPs, the author considers that the patients may take a drug holiday or be switched to alternative therapy. Denosumab may be used continuously for years and, unlike BPs, does not require discontinuation. It is effective in both untreated and already BP-treated patients. At the same time, when the treatment is discontinued, the effect of denosumab is reversible; therefore, oral BP or intravenous zoledronic acid is recommended to maintain the achieved effect.

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Three Years' Experience With the Biological Agent Denosumab Used to Treat Women With Postmenopausal Osteoporosis: Efficacy, Safety and Treatment Adherence

Cited by 3 publications

References 13 publications

Drug-induced lupus

Drug-induced lupus

Steroid osteoporosis within the framework of the Itsenko-Cushing drug syndrome: demonstration of a clinical case

Treatment of patients with osteoporosis: issues of therapy duration, adherence, and replacement

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