“…Randomized trials and nonrandomized controlled trials of transfemoral TAVI describe incidences from 6% to 11% and 3% to 11%, respectively [3,[14][15][16][17]. Supported by Barbanti and colleagues [18], who described no significant difference in vascular outcome between highly (The Society of Thoracic Surgeons score more than 7) or less cardiovascular affected (The Society of Thoracic Surgeons score less than 7) transfemoral TAVI patients [18], we expect that the impact of patient characteristics on vascular outcome is relatively small. Based on our results, we hypothesize that the combination of axillary access by surgical cutdown [19], the proximity to the native valve with less bending of the delivery device, less shear stress along the aortic wall, and lower burden of atherosclerotic disease all contribute to favorable vascular outcome.…”