Three-year follow-up of the ARTS-II# – sirolimus-eluting stents for the treatment of patients with multivessel coronary artery disease

Serruys, Patrick W.; Daemen, Joost; Morice, Marie‐Claude; Bruyne, Bernard De; Colombo, Antonio; Macaya, Carlos; Richardt, Gert; Fajadet, Jean; Hamm, Christian W.; Dawkins, Keith D.; Vranckx, Pascal; Bressers, Marco; Domburg, Ron van; Schuijer, Monique; Wittebols, Kristel; Pieters, Magdaleen; Stoll, Hans Peter

doi:10.4244/eijv3i4a81

Cited by 48 publications

(35 citation statements)

References 24 publications

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“…In contrast to the above trials, the ARTS-II registry (consisting of patients with multivessel disease treated with DES) has reported 1-year results similar to the CABG cohorts in the first ARTS study. 24 The dramatic reduction of TVF and subsequent revascularization seen with DES propounds the possibility that a strategy of PCI with DES conferred at least similar if not beneficial results compared with CABG. This possibility prompted the present study.…”

Section: Javaid Et Al Cabg Vs Pci With Des For Multivessel Cad Patienmentioning

confidence: 99%

“…22,23 Theoretically, this should reduce the combined end points (mortality, MI, and TVF) that often comprise the primary end points of pivotal trials. Using DES, the Arterial Revascularization Therapies Study Part II (ARTS-II) investigators 24 reported favorable early results, and prospective, randomized trials comparing PCI with DES and CABG in patients with multivessel disease and in diabetics are currently under way. 25 We evaluated outcomes associated with PCI with DES and CABG in a "real-world" population of patients with multivessel disease at a single high-volume center.…”

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confidence: 99%

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Outcomes of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention With Drug-Eluting Stents for Patients With Multivessel Coronary Artery Disease

et al. 2007

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Background-Advances in coronary artery bypass grafting (CABG) surgery and percutaneous coronary intervention (PCI) with drug-eluting stents have dramatically improved results of these procedures. The optimal treatment for patients with multivessel coronary artery disease is uncertain given the lack of prospective, randomized data reflecting current practice. This study represents a "real-world" evaluation of current technology in the treatment of multivessel coronary artery disease. Methods and Results-A total of 1680 patients undergoing revascularization for multivessel coronary artery disease were identified. Of these, 1080 patients were treated for 2-vessel disease (196 CABG and 884 PCI) and 600 for 3-vessel disease (505 CABG and 95 PCI). One-year mortality, cerebrovascular events, Q-wave myocardial infarction, target vessel failure, and composite major adverse cardiovascular and cerebrovascular events were compared between the CABG and PCI cohorts. Outcomes were adjusted for baseline covariates and reported as hazard ratios.

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Section: Javaid Et Al Cabg Vs Pci With Des For Multivessel Cad Patienmentioning

confidence: 99%

mentioning

confidence: 99%

Outcomes of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention With Drug-Eluting Stents for Patients With Multivessel Coronary Artery Disease

et al. 2007

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“…It was demonstrated that the SYNTAX score was one of the strongest predictors of MACE (odds ratio [OR] 1.43, 95% confidence interval [95% CI] 1.08-1.90; P = 0.014), as was diabetes mellitus (OR 1.76, 95% CI 1.13-2.74; P = 0.012). 8 This evidence was used to determine which patients would be ineligible for percutaneous revascularisation techniques, based on higher anatomic complexity.…”

Section: Discussionmentioning

confidence: 99%

Impacto do escore SYNTAX na estratificação de risco após intervenção coronária percutânea em pacientes não-selecionados

Barbosa¹,

Costa²,

Feres³

et al. 2012

Rev. Bras. Cardiol. Invasiva

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Background:The SYNTAX score was developed as an angiographic tool to grade the complexity of coronary artery disease in patients with three-vessel and/or left main disease. The role of this score in predicting clinical outcomes after percutaneous coronary intervention (PCI) in non-selected patients treated in the daily clinical practice of a referral centre was evaluated. Methods: Analysis of patients undergoing PCI from March to September of 2009, and at the 12-month follow-up. Patients were divided into tertiles according to the SYNTAX score. The primary endpoint included major adverse cardiac events (MACE) -death, non-fatal acute myocardial infarction, and target-vessel revascularisation. The ability of the SYNTAX score to predict MACE was assessed by the receiver operator characteristic (ROC) curve. Results: Two hundred and thirty-four patients with a mean SYNTAX score of 11.6 ± 6.2 points were included. Tertile I had a SYNTAX score ≤ 9 (average 5.9); tertile II, > 9 and ≤ 13 (average 10.8); and tertile III, > 13 (average 18.3). During the clinical follow-up of 7.2 ± 4.9 months, the incidence of MACE was greater in tertile III than in tertiles I and II (2.5% vs. 6.4% vs. 14.1%; P = 0.0075). The ROC curve showed an area under the curve of 0.667 (P = 0.012), indicating a moderate ability to anticipate the occurrence of MACE in this population. Conclusions: The SYNTAX score proved to be useful in predicting the occurrence of MACE after PCI in patients treated in clinical practice.

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“…However, in the last years, evidence has narrowed the indication of revascularization procedures in stable patients, with conflicting results regarding the benefits and impact on mortality when comparing the initial treatment options. [1][2][3][4][5][6][7][8][9] Prior studies have suggested that PCI decreases symptoms without a long-term prognostic effect, even when compared to medical treatment alone. 7,8 More recent data reinforced the superiority of CABG in preventing major cardiac events in patients with multivessel disease, especially in patients with more complex coronary artery disease and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Medical and Revascularization Procedures as the Initial Strategy in Stable Coronary Artery Disease: A Cohort Study

Furtado

Araújo

Jost

et al. 2017

International Journal of Cardiovascular Sciences

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Three-year follow-up of the ARTS-II# – sirolimus-eluting stents for the treatment of patients with multivessel coronary artery disease

Cited by 48 publications

References 24 publications

Outcomes of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention With Drug-Eluting Stents for Patients With Multivessel Coronary Artery Disease

Outcomes of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention With Drug-Eluting Stents for Patients With Multivessel Coronary Artery Disease

Impacto do escore SYNTAX na estratificação de risco após intervenção coronária percutânea em pacientes não-selecionados

Effectiveness of Medical and Revascularization Procedures as the Initial Strategy in Stable Coronary Artery Disease: A Cohort Study

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