Three-week treadmill training changes the electrophysiological properties of spinal interneurons in the mice

Chen, Ke; Ge, Renkai; Cheng, Yi; Dai, Yue

doi:10.1007/s00221-019-05647-3

Cited by 7 publications

(16 citation statements)

References 44 publications

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“…However, it must be noted that these latter studies were cross-sectional and the tested populations were elite in terms of their performance, making it difficult to separate the effect of training and heritability (Georgiades et al 2017). In conclusion, because many different plasticity mechanisms co-exist in the spinal cord (Wang & Brehm, 2017;Bertuzzi et al 2018;Chen et al 2019), short-and long-term general and task-specific adaptations most probably co-exist.…”

Section: Discussionmentioning

confidence: 99%

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Motor learning induces time‐dependent plasticity that is observable at the spinal cord level

Giboin

Tokuno

Krämer

et al. 2020

The Journal of Physiology

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The spinal cord is an important contributor to motor learning r It remains unclear whether short-term spinal cord adaptations are general or task-specific r Immediately after task acquisition, neural adaptations were not specific to the trained task (i.e. were general) r Twenty-four hours after acquisition, neural adaptations appeared to be task-specific r The neural reorganization and generalization of spinal adaptations appears to be timedependent.

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Section: Discussionmentioning

confidence: 99%

“…2018; Chen et al . 2019), short‐ and long‐term general and task‐specific adaptations most probably co‐exist.…”

Section: Discussionmentioning

confidence: 99%

Motor learning induces time‐dependent plasticity that is observable at the spinal cord level

Giboin

Tokuno

Krämer

et al. 2020

The Journal of Physiology

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“…One of the mechanisms responsible for the neural adaptations to exercise training was modulation of ion channels, including acute modulation of channel kinetics and chronic changes in the density, location, or types of ion channels (Gardiner, 2006 ; Chen et al, 2019 ). In this study, neuronal properties were measured 24 h after the last exercise training.…”

Section: Discussionmentioning

confidence: 99%

Three-Week Treadmill Exercise Enhances Persistent Inward Currents, Facilitates Dendritic Plasticity, and Upregulates the Excitability of Dorsal Raphe Serotonin Neurons in ePet-EYFP Mice

Dai

2020

Front. Cell. Neurosci.

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Exercise plays a key role in preventing or treating mental or motor disorders caused by dysfunction of the serotonergic system. However, the electrophysiological and ionic channel mechanisms underlying these effects remain unclear. In this study, we investigated the effects of 3-week treadmill exercise on the electrophysiological and channel properties of dorsal raphe nucleus (DRN). Serotonin (5-HT) neurons in ePet-EYFP mice, using whole-cell patch clamp recording. Treadmill exercise was induced in ePet-EYFP mice of P21-24 for 3 weeks, and whole-cell patch clamp recording was performed on EYFP-positive 5-HT neurons from DRN slices of P42-45 mice. Experiment data showed that 5-HT neurons in the DRN were a heterogeneous population with multiple firing patterns (single firing, phasic firing, and tonic firing). Persistent inward currents (PICs) with multiple patterns were expressed in 5-HT neurons and composed of Cav1.3 (Ca-PIC) and sodium (Na-PIC) components. Exercise hyperpolarized the voltage threshold for action potential (AP) by 3.1 ± 1.0 mV (control: n = 14, exercise: n = 18, p = 0.005) and increased the AP amplitude by 6.7 ± 3.0 mV (p = 0.031) and firing frequency by more than 22% especially within a range of current stimulation stronger than 70 pA. A 3-week treadmill exercise was sufficient to hyperpolarize PIC onset by 2.6 ± 1.3 mV (control: −53.4 ± 4.7 mV, n = 28; exercise: −56.0 ± 4.7 mV, n = 25, p = 0.050) and increase the PIC amplitude by 28% (control: 193.6 ± 81.8 pA; exercise: 248.5 ± 105.4 pA, p = 0.038). Furthermore, exercise hyperpolarized Na-PIC onset by 3.8 ± 1.8 mV (control: n = 8, exercise: n = 9, p = 0.049) and increased the Ca-PIC amplitude by 23% (p = 0.013). The exercise-induced enhancement of the PIC amplitude was mainly

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“…Following rapid toe movement, well-trained swimmers demonstrated higher spinal excitability than non-trained individuals (Ogawa et al 2009 ), and similar results were later presented in endurance runners (Ogawa et al 2012 ). In general, long-term endurance training results in enhanced spinal excitability and provides increased blood flow, and oxygen delivery through angiogenesis, to brain regions, but appears not to participate directly in the modulation of synaptic number or topology (Churchill et al 2002 ; Taubert et al 2015 ; Chen et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Modulations of corticospinal excitability following rapid ankle dorsiflexion in skill- and endurance-trained athletes

Avela

Kidgell

et al. 2022

Eur J Appl Physiol

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Purpose Long-term sports training, such as skill and endurance training, leads to specific neuroplasticity. However, it remains unclear if muscle stretch-induced proprioceptive feedback influences corticospinal facilitation/inhibition differently between skill- and endurance-trained athletes. This study investigated modulation of corticospinal excitability following rapid ankle dorsiflexion between well-trained skill and endurance athletes. Methods Ten skill- and ten endurance-trained athletes participated in the study. Corticospinal excitability was tested by single- and paired-pulse transcranial magnetic stimulations (TMS) at three different latencies following passive rapid ankle dorsiflexion. Motor evoked potential (MEP), short-latency intracortical inhibition (SICI), intracortical facilitation (ICF), and long-latency intracortical inhibition (LICI) were recorded by surface electromyography from the soleus muscle. Results Compared to immediately before ankle dorsiflexion (Onset), TMS induced significantly greater MEPs during the supraspinal reaction period (~ 120 ms after short-latency reflex, SLR) in the skill group only (from 1.7 ± 1.0 to 2.7 ± 1.8%M-max, P = 0.005) despite both conditions being passive. ICF was significantly greater over all latencies in skill than endurance athletes (F(3, 45) = 4.64, P = 0.007), although no between-group differences for stimulations at specific latencies (e.g., at SLR) were observed. Conclusion The skill group showed higher corticospinal excitability during the supraspinal reaction phase, which may indicate a “priming” of corticospinal excitability following rapid ankle dorsiflexion for a supraspinal reaction post-stretch, which appears absent in endurance-trained athletes.

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Three-week treadmill training changes the electrophysiological properties of spinal interneurons in the mice

Cited by 7 publications

References 44 publications

Motor learning induces time‐dependent plasticity that is observable at the spinal cord level

Motor learning induces time‐dependent plasticity that is observable at the spinal cord level

Three-Week Treadmill Exercise Enhances Persistent Inward Currents, Facilitates Dendritic Plasticity, and Upregulates the Excitability of Dorsal Raphe Serotonin Neurons in ePet-EYFP Mice

Modulations of corticospinal excitability following rapid ankle dorsiflexion in skill- and endurance-trained athletes

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