Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

Fisher, Patrick M.; Madsen, Mogens; Mahon, Brenda Mc; Holst, Klaus K.; Andersen, S. B.; Laursen, Helle Ruff; Hasholt, Lis; Siebner, Hartwig R.; Knudsen, Gitte M.

doi:10.1016/j.biopsych.2013.11.031

Cited by 36 publications

(36 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All participants were recruited from the Copenhagen region via online advertisements for research projects approved by the Ethics Committee of Copenhagen and Frederiksberg, Denmark (H-1-2010-091, amendments: 28633, 30043;H-1-2010-085, amendments 28641, 33540;(KF)01-2006-20, amendment: 23504, 23830). Emotional faces fMRI data from 30 [Fisher et al, 2014b] and 32 [Fisher et al, 2015] of the participants included in the current study have been described in unrelated studies. Notably, some projects recruited only males and others recruited based on 5-HTTLPR genotype status (i.e., oversampling of L A L A and S 0 S 0 individuals).…”

Section: Participantsmentioning

confidence: 99%

“…Participants underwent a scan session in a 3T-Trio MRI scanner using an eight-channel head coil (Siemens, Erlangen, Germany) as described previously [Fisher et al, 2014b;Grady et al, 2013;Hornboll et al, 2013]. Blood oxygen level-dependent (BOLD) functional magnetic resonance images (fMRI) images were acquired using a T2*-weighted echo-planar imaging sequence (repetition time 5 2500 msec, echo time 5 26 msec, flip angle 5 76 , in-plane matrix 5 64 3 64, in-plane resolution 5 3 3 3 mm, number of slices within a whole-brain volume 5 41, slice thickness 5 3 mm, gap 5 0.75 mm).…”

Section: Magnetic Resonance Imaging Acquisitionmentioning

confidence: 99%

“…Participants completed a gender discrimination task described previously [Fisher et al, 2014b;Hornboll et al, 2013] including blocks of fearful, angry or neutral faces from the Karolinska Directed Emotional Faces database [Lundqvist et al, 1998]. Each trial consisted of the stimulus presented for 1800 ms and an inter-stimulus interval of 200 ms during which time a fixation cross ("1") was present on the screen.…”

Section: Emotional Faces Paradigmmentioning

confidence: 99%

“…ac.uk/spm/) and VBM5 (http://dbm.neuro.uni-jena.de/ vbm/vbm5-for-spm5/) in Matlab version 8.1 (www.mathworks.com) as previously described [Fisher et al, 2014b]. ac.uk/spm/) and VBM5 (http://dbm.neuro.uni-jena.de/ vbm/vbm5-for-spm5/) in Matlab version 8.1 (www.mathworks.com) as previously described [Fisher et al, 2014b].…”

Section: Functional Magnetic Resonance Imaging Data Analysismentioning

confidence: 99%

See 3 more Smart Citations

5‐HTTLPR differentially predicts brain network responses to emotional faces

Fisher

Grady

Madsen

et al. 2015

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

The effects of the 5-HTTLPR polymorphism on neural responses to emotionally salient faces have been studied extensively, focusing on amygdala reactivity and amygdala-prefrontal interactions. Despite compelling evidence that emotional face paradigms engage a distributed network of brain regions involved in emotion, cognitive and visual processing, less is known about 5-HTTLPR effects on broader network responses. To address this, we evaluated 5-HTTLPR differences in the whole-brain response to an emotional faces paradigm including neutral, angry and fearful faces using functional magnetic resonance imaging in 76 healthy adults. We observed robust increased response to emotional faces in the amygdala, hippocampus, caudate, fusiform gyrus, superior temporal sulcus and lateral prefrontal and occipito-parietal cortices. We observed dissociation between 5-HTTLPR groups such that LA LA individuals had increased response to only angry faces, relative to neutral ones, but S' carriers had increased activity for both angry and fearful faces relative to neutral. Additionally, the response to angry faces was significantly greater in LA LA individuals compared to S' carriers and the response to fearful faces was significantly greater in S' carriers compared to LA LA individuals. These findings provide novel evidence for emotion-specific 5-HTTLPR effects on the response of a distributed set of brain regions including areas responsive to emotionally salient stimuli and critical components of the face-processing network. These findings provide additional insight into neurobiological mechanisms through which 5-HTTLPR genotype may affect personality and related risk for neuropsychiatric illness.

show abstract

Section: Participantsmentioning

confidence: 99%

Section: Magnetic Resonance Imaging Acquisitionmentioning

confidence: 99%

Section: Emotional Faces Paradigmmentioning

confidence: 99%

Section: Functional Magnetic Resonance Imaging Data Analysismentioning

confidence: 99%

See 2 more Smart Citations

5‐HTTLPR differentially predicts brain network responses to emotional faces

Fisher

Grady

Madsen

et al. 2015

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, a recent critical review of light therapy literature showed that most bright light therapy studies have methodological issues and evidence is not unequivocal 17 . Further, cognitive response to bright light therapy can vary based on genetics 18 . A proper prescription for light therapy requires knowing the dim light melatonin onset (DLMO) of SAD individuals (2/3 are phase-delayed) to determine circadian phase 19 .…”

Section: Introductionmentioning

confidence: 99%

Normalizing sleep quality disturbed by psychiatric polypharmacy: a single patient open trial (SPOT)

2016

View full text Add to dashboard Cite

There is a growing interest in personalized and preventive medicine initiatives that leverage serious patient engagement, such as those initiated and pursued among participants in the quantified-self movement. However, many of the self-assessments that result are not rooted in good scientific practices, such as exploiting controls, dose escalation strategies, multiple endpoint monitoring, etc. Areas where individual monitoring and health assessments have great potential involve sleep and behavior, as there are a number of very problematic sleep and behavior-related conditions that are hard to treat without personalization. For example, winter depression or seasonal affective disorder (SAD) is a serious, recurrent, atypical depressive disorder impacting millions each year. In order to prevent yearly recurrence antidepressant drugs are used to prophylactically treat SAD. In turn, these antidepressant drugs can affect sleep patterns, further exacerbating the condition. Because of this, possibly unique combinatorial or ‘polypharmaceutical’ interventions involving sleep aids may be prescribed. However, little research into the effects of such polypharmacy on the long-term sleep quality of treated individuals has been pursued. Employing wireless monitoring in a patient-centered study we sought to gain insight into the influence of polypharmacy on sleep patterns and the optimal course of therapy for an individual being treated for SAD with duloxetine (Cymbalta) and temazepam. We analyzed continuous-time sleep data while dosages and combinations of these agents were varied. We found that the administration of Cymbalta led to an exacerbation of the subject’s symptoms in a statistically significant way. We argue that such analyses may be necessary to effectively treat individuals with similar overall clinical manifestations and diagnosis, despite their having a unique set of symptoms, genetic profiles and exposure histories. We also consider the limitations of our study and areas for further research.

show abstract

Imaging genetics in neurodevelopmental psychopathology

Klein

Donkelaar

Verhoef

et al. 2017

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Neurodevelopmental disorders are defined by highly heritable problems during development and brain growth. Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and intellectual disability (ID) are frequent neurodevelopmental disorders, with common comorbidity among them. Imaging genetics studies on the role of disease-linked genetic variants on brain structure and function have been performed to unravel the etiology of these disorders. Here, we reviewed imaging genetics literature on these disorders attempting to understand the mechanisms of individual disorders and their clinical overlap. For ADHD and ASD, we selected replicated candidate genes implicated through common genetic variants. For ID, which is mainly caused by rare variants, we included genes for relatively frequent forms of ID occurring comorbid with ADHD or ASD. We reviewed case-control studies and studies of risk variants in healthy individuals. Imaging genetics studies for ADHD were retrieved for SLC6A3/DAT1, DRD2, DRD4, NOS1, and SLC6A4/5HTT. For ASD, studies on CNTNAP2, MET, OXTR, and SLC6A4/5HTT were found. For ID, we reviewed the genes FMR1, TSC1 and TSC2, NF1, and MECP2. Alterations in brain volume, activity, and connectivity were observed. Several findings were consistent across studies, implicating, for example, SLC6A4/5HTT in brain activation and functional connectivity related to emotion regulation. However, many studies had small sample sizes, and hypothesis-based, brain region-specific studies were common. Results from available studies confirm that imaging genetics can provide insight into the link between genes, disease-related behavior, and the brain. However, the field is still in its early stages, and conclusions about shared mechanisms cannot yet be drawn.

show abstract

Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

Cited by 36 publications

References 42 publications

5‐HTTLPR differentially predicts brain network responses to emotional faces

5‐HTTLPR differentially predicts brain network responses to emotional faces

Normalizing sleep quality disturbed by psychiatric polypharmacy: a single patient open trial (SPOT)

Imaging genetics in neurodevelopmental psychopathology

Contact Info

Product

Resources

About