Three Unsuspected CT Diagnoses of COVID-19

Abstract

PURPOSE: Coronavirus disease 2019 (COVID-19) is caused by a novel strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has quickly spread around the globe. Health care facilities in the United States currently do not have an adequate supply of COVID-19 tests to meet the growing demand. Imaging findings for COVID-19 are nonspecific but include pulmonary parenchymal ground-glass opacities in a predominantly basal and peripheral distribution.METHODS: Three patients imaged for non-respiratory related symptoms with a portion of the lungs in the imaged field.RESULTS: Each patient had suspicious imaging findings for COVID-19, prompting the interpreting radiologist to suggest testing for COVID-19. All 3 patients turned out to be infected with COVID-19 and one patient is the first reported case of the coincident presentation of COVID-19 and an intraparenchymal hemorrhage.CONCLUSION: Using imaging characteristics of COVID-19 on abdominal or neck CT when a portion of the lungs is included, patients not initially suspected of COVID-19 infection can be quarantined earlier to limit exposure to others.

Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis

“…One prospective study 10 , 35 retrospective studies 1,3, , and 13 case report/series [44][45][46][47][48][49][50][51][52][53][54][55][56] with information from a total of 6,335 individuals with COVID-19 infection were involved in this THE CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES review. Patient data from the included studies were obtained from various countries, as follows: China, France, India, Iran, Japan, South Korea, Spain, Thailand, and the USA.…”

“…Vascular disorders were noted to be most frequent (n = 23; 69.7%); these presented as acute cerebral infarction (n = 18), acute intracerebral hemorrhage (n = 4), and cerebral venous sinus thrombosis (n = 1); eight cases survived and five cases died. 3,14,46,50,51 Four case reports described patients who manifested with encephalopathy/ encephalitis, with two patients recovering. 44,49,53,54 A COVID-19 case with documented acute necrotizing hemorrhagic encephalopathy presented as altered mental status but the patient's outcome was unclear.…”

COVID-19 Impact on Neurosurgical Practice: Lockdown Attitude and Experience of a European Academic Center

“…Major hemorrhagic complications with spontaneous intraparenchymal bleeding in severely infected patients are starting to emerge in the literature. [19][20][21][22] Panciani et al 23 described 4 patients with COVID-19 who underwent surgery or embolization for chronic subdural hematomas, with a mortality of 100%. Sharifi-Razavi et al 21 hypothesized that the angiotensinconverting-enzyme II receptor, used by the SARS-CoV-2 virus for cell entry, is responsible for dysfunction of the cerebrovascular endothelial cells and may lead to disruption of autoregulation as well as blood pressure spikes as a result of arterial wall rupture.…”

“…Major hemorrhagic complications with spontaneous intraparenchymal bleeding in severely infected patients are starting to emerge in the literature. 19 , 20 , 21 , 22 Panciani et al. 23 described 4 patients with COVID-19 who underwent surgery or embolization for chronic subdural hematomas, with a mortality of 100%.…”

COVIDXception-Net: A Bayesian Optimization Based Deep Learning Approach to Diagnose COVID-19 from X-Ray Images

“…In case of COVID-19, the most common CXR and CT findings are Ground Glass Opacity (GGO) and lung consolidation [9]. CT was found helpful in early diagnosis of COVID-19 even when the patient did not show any respiratory symptoms or fever [44]. In some cases, GGO was seen Fig.…”