Three types of ossifying fibroma: A report of 4 cases with an analysis of CBCT features

Abstract

Ossifying fibroma is a slow-growing benign neoplasm that occurs most often in the jaws, especially the mandible. The tumor is composed of bone that develops within fibrous connective tissue. Some ossifying fibromas consist of cementum-like calcifications, while others contain only bony material; however, a mixture of these calcification types is commonly seen in a single lesion. Of the craniofacial bones, the mandible is the most commonly involved site, with the lesion typically inferior to the premolars and molars. Ossifying fibroma of the jaw shows a female predominance. Some reports of ossifying fibroma have been published in the literature; however, this report continues the research on this topic by detailing 3 types of ossifying fibroma findings on panoramic radiographs and cone-beam computed tomographic images of 4 patients. The radiographs of the presented cases could help clinicians understand the variations in the radiographic appearance of this lesion.

Ossifying Fibroma in the Maxilla and Mandible: A Case Report With a Brief Literature Review

“…OF is the most common fibro-osseous tumor that presents as a slow-growing, encapsulated benign neoplasm composed of varying amounts of bone or cementum-like tissue in a fibrous stroma welldemarcated from adjacent normal bone [2]. It is most common in the jaw bones, with a predilection for the mandible.…”

“…Due to the presence of cementum-like tissue and bone in OF, the term OF or COF is sometimes used to describe this tumor. However, the consensus is that these terms describe similar underlying histology and are thus the same underlying type of lesion [2]. The cell of origin is unknown, although it is presumed to arise from multipotential mesenchymal cells in the periodontal ligament space [3].…”

An Uncommon Presentation of Ossifying Fibroma in the Maxilla

“…Only a few lesions are radiolucent, while the vast majority appear as distinctly mixed density lesions (predominantly radiopaque), and it is determined by the maturity of mineralized contents. Few aggressive ossifying fibromas of the maxilla resemble ground-glass appearance [ 10 ]. The typical OF grows in a centrifugal pattern, expanding in all directions, and leading to cortical expansion parallel to the growth area.…”

A practical overview of CT and MRI features of developmental, inflammatory, and neoplastic lesions of the sphenoid body and clivus

“…Intraosseous meningioma — compared with fibrous dysplasia — shows feathering of lesions edges, soft tissue involvement and vivid homogenous CE [ 41 ]. Ossifying fibroma is a benign tumour with similar features, but it typically shows better-defined boundaries with osteosclerotic shells, whereas the periphery of fibrous dysplasia usually blends with the surrounding bone [ 42 ]. Malignant transformation of fibrous dysplasia into osteosarcoma should be suspected by the presence of periosteal response on CT and by areas of restricted diffusion on MRI, although these are not specific signs [ 39 , 43 ].…”