Three sudden deaths in men associated with undiagnosed chronic thyroiditis

Edston, Erik

doi:10.1007/bf01355524

Cited by 21 publications

(14 citation statements)

References 25 publications

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“…Such an undiagnosed chronic thyroiditis has been described in cases of sudden death [4] and in our case, postmortem biochemistry results were consistent with Hashimoto's disease. Edston et al [5] showed that it is possible to use postmortem measurements of thyroid function in combination with histology but postmortem thyroxin and TSH blood levels must be carefully interpreted.…”

Section: Discussionsupporting

confidence: 89%

Myocarditis associated with Hashimoto’s disease: a case report

et al. 2003

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We report on a sudden cardiac death case involving a 40-year-old man with no known medical history. Forensic autopsy showed lymphocytic myocarditis associated with lymphocytic thyroiditis. In both the heart and the thyroid gland, the inflammatory foci often had a nodular pattern with a germinal centre. Virological and toxicological analyses were negative. Postmortem biochemistry showed a slight increase in TSH in combination with normal T3 and T4 blood levels suggesting hypothyroidism. High titres of antiperoxidase and antithyroglobulin antibodies with normal levels of TSH receptor antibodies, in addition to biological hypothyroidism and lymphocytic inflammation were consistent with the diagnosis of Hashimoto's thyroiditis. Immunohistochemical studies excluded a lymphoma and showed no evidence of viral myocarditis. In contrast to Grave's disease, Hashimoto's thyroiditis has never been reported in association with myocarditis as a cause of sudden death. We conclude that the cardiac immunological and histological pattern, similar to that found in the thyroid gland suggests an autoimmune myocarditis.

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Section: Discussionsupporting

confidence: 89%

Myocarditis associated with Hashimoto’s disease: a case report

et al. 2003

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“…Hypokalemia can be a cause of ventricular fibrillation in Cushing's syndrome [395]. Thyroid-related heart disease is recognized [396,397], but there has been recent interest in an apparent association between chronic thyroiditis and sudden death [398][399][400]. Death due to presumed arrhythmia has been noted in association with thyrotoxicosis [39] and abuse of thyroid hormone [401].…”

Section: Central Nervous System Causes Of Sudden Deathmentioning

confidence: 99%

Sudden adult death

Langlois

2009

Forensic Sci Med Pathol

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In the investigation of sudden death in adults, channelopathies, such as long QT syndrome, have risen to the fore in the minds of forensic pathologists in recent years. Examples of these disorders are touched upon in this review as an absence of abnormal findings at postmortem examination is characteristic and the importance of considering the diagnosis lies in the heritable nature of these conditions. Typically, a diagnosis of a possible channelopathy is evoked as an explanation for a 'negative autopsy' in a case of apparent sudden natural death. However, the one potential adverse effect of this approach is that subtle causes of sudden death may be overlooked. The intention of this article is to review and discuss potential causes of sudden adult death (mostly natural) that should be considered before resorting to a diagnosis of possible channelopathy. Nonetheless, it becomes apparent that many of the potential causes of sudden death can have a genetic basis. Thus, it becomes an important consideration that there may be a genetic basis to sudden death that extends beyond the negative autopsy.

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“…Recently studies about the postmortem applications of other markers (thyroid hormones, biogenic amines and antioxidant related enzymes) involved in sudden death have been published (Edston 1996;Hirvonen and Huttunen 1996;Ramos et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Cardiac troponin I (cTn I) and the postmortem diagnosis of myocardial infarction

Osuna

Pérez-Cárceles

Alvarez

et al. 1998

International Journal of Legal Medicine

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In clinical practice several biochemical markers are used for the diagnosis of myocardial infarction. Because of its extremely high specificity for myocardial damage, cardiac troponin I (cTn I) is frequently used. The aim of this study was to evaluate the diagnostic efficacy of postmortem cTn I determinations in pericardial fluid and serum and to compare these results with other biochemical markers and with structural findings used to diagnose acute myocardial ischaemia. We studied 89 cadavers with a mean age of 51.38 +/- 2.04 (SD 19.27 years). Cases were allocated to 1 of 4 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. In pericardial fluid we obtained statistically significant differences for the four biochemical parameters, while in serum myosin heavy chains and myoglobin showed statistically significant differences. The highest levels of biochemical markers in pericardial fluid were observed in subjects who had died from definite myocardial infarction.

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Three sudden deaths in men associated with undiagnosed chronic thyroiditis

Cited by 21 publications

References 25 publications

Myocarditis associated with Hashimoto’s disease: a case report

Myocarditis associated with Hashimoto’s disease: a case report

Sudden adult death

Cardiac troponin I (cTn I) and the postmortem diagnosis of myocardial infarction

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