Abstract:Post-Golgi trafficking of the major fast axonally transported (FT) proteins was investigated in the rat optic pathway. Following intra-ocular injection of 35S-methionine, radiolabeled FT proteins in the optic tract (OT) and superior colliculus (SC) were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and fluorography. Twenty FT proteins, including a known plasma membrane protein (SNAP-25) and synaptic vesicle protein (synaptobrevin-2), displayed consistent 2D-PAGE migration behavior an… Show more
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