Three stages of the menopausal transition from the Seattle Midlife Womenʼs Health Study: toward a more precise definition

Mitchell, Ellen Sullivan; Woods, Nancy Fúgate; Mariella, Anne

doi:10.1097/00042192-200007050-00008

Cited by 151 publications

(118 citation statements)

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“…Previous studies have explored CAM intake in the general population (Eisenberg et al, 1998;MacLennan et al, 1996), in women aged 15-60 years for reproductive conditions (Biddle et al, 2003), explored a limited range of CAMS (Anderson & Posner, 2002;Mitchell et al, 2000), or have given a preliminary indication of the types used during menopause (Newton et al, 2002). Yet few studies exist on the use of CAMs during the menopausal period.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 22% had used CAMs specifically to treat menopausal symptoms; the three most commonly cited were natural therapies, including herbal and naturopathic remedies (13%), followed by relaxation (9%) and dietary soy supplements (7%). In the Seattle Midlife Women's Health Study, a study of women aged 42-61 years, 10% used exercise and yoga to treat depression and although CAM use was low, women indicated that they were "very" or a "bit effective" (Mitchell, Woods, & Mariella, 2000). A study of 207 Australian women aged 45-54 years investigated the use of selected CAMs and found that 61% of women ate healthy foods and 61% participated in regular physical Activity to improve their health (Anderson & Posner, 2002).…”

Section: Introductionmentioning

confidence: 99%

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The use of complementary and alternative medications by menopausal women in South East Queensland

Gollschewski

Anderson

Skerman

et al. 2004

Women’s Health Issues

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This study aimed to identify the prevalence and types of complementary and alternative medications (CAMs) used by women during menopause and explore potential associations between CAM use and menopausal symptoms. Analysis was undertaken with 886 randomly selected menopausal women aged 47-67 years who participated in a postal questionnaire on the menopause experience. The prevalence of CAM use was relatively high (82.5%), with nutrition most commonly cited (67%), followed by phytoestrogens (56%), herbal therapies (41%), and CAM medications (25%). Multivariate analysis adjusted for confounders revealed that women who consumed CAM medications were 17-23% more likely to report anxiety (p _ .019) or vasomotor symptoms (p _ .013). Women who used herbal therapies (p _ .009) or phytoestrogens (p _ .030) were 13-16% more likely to experience vasomotor symptoms. Women who used nutrition were 18% more likely to experience anxiety (p _ .049). These results highlight the importance for health professionals to incorporate CAMs into their practice to better inform menopausal women of their treatment choices.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The use of complementary and alternative medications by menopausal women in South East Queensland

Gollschewski

Anderson

Skerman

et al. 2004

Women’s Health Issues

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“…There is no available uniform definition for menopausal transition, although recently some definitions based on increasing variability in cycle length have been proposed (20,21). We defined menopausal transition in two ways.…”

Section: Methodsmentioning

confidence: 99%

Serum antimüllerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: A longitudinal study

Rooij

Broekmans

Scheffer

et al. 2005

Fertility and Sterility

521

295

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Objective: The aim of this study was to assess which of the basal ovarian reserve markers provides the best reflection of the changes occurring in ovarian function over time (i.e., reproductive aging). Design: Prospective longitudinal study. Setting: Healthy volunteers in an academic research center. Patient(s): Eighty-one women with normal reproductive performance during the course of their lives were longitudinally assessed. In this select group of women, becoming chronologically older was considered as a proxy variable for becoming older from a reproductive point of view. Intervention(s):The women were assessed twice, with on average a 4-year interval (T 1 and T 2 ). The number of antral follicles on ultrasound (AFC) and blood levels of antimüllerian hormone (AMH), FSH, inhibin B, and E 2 were assessed. Main Outcome Measure(s): Longitudinal changes of the markers mentioned and the consistency of these parameters over time. Result(s):The mean ages at T 1 and T 2 were 39.6 and 43.6 years, respectively. Although AFC was strongly associated with age in a cross-sectional fashion, it did not change over time. The AMH, FSH, and inhibin B levels showed a significant change over time, in contrast to E 2 levels. The AMH and AFC were highly correlated with age both at T 1 and T 2 , whereas FSH and inhibin B predominantly changed in women more than 40 years of age. To assess the consistency of these parameters over time, we investigated whether a woman's individual level above or below the mean of her age group at T 1 remained above or below the mean of her age group at T 2 . Serum AMH concentrations showed the best consistency, with AFC as second best. The FSH and inhibin B showed only modest consistency, whereas E 2 showed no consistency at all. Conclusion(s):These results indicate that serum AMH represents the best endocrine marker to assess the age-related decline of reproductive capacity. (Fertil Steril 2005;83:979 -87.

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“…This definition was based on an adaptation of recent results from three studies (4)(5)(6)(7). Together these three studies identified five different criteria, or marker events, for the onset of early transition.…”

Section: Introductionmentioning

confidence: 99%

The ReSTAGE Collaboration: defining optimal bleeding criteria for onset of early menopausal transition

Harlow

Mitchell

Crawford

et al. 2008

Fertility and Sterility

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Study objective-Criteria for staging the menopausal transition are not established. This paper evaluates five bleeding criteria for defining early transition and provides empirically-based guidance regarding optimal criteria. Main outcome measure(s)-Age at and time to menopause for: standard deviation >6 and >8 days, persistent difference in consecutive segments >6 days, irregularity, and >=45 day segment. Serum follicle stimulating hormone concentration.Results-Most women experienced each of the bleeding criteria. Except for persistent >6 day difference which occurs earlier, the criteria occur at a similar age and at approximately the same age as late transition in a large proportion of women. FSH was associated with all proposed markers.Conclusions-The early transition may be best described by ovarian activity consistent with the persistent >6 day difference, but further study is needed, as other proposed criterion are consistent with later menstrual changes.

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Three stages of the menopausal transition from the Seattle Midlife Womenʼs Health Study: toward a more precise definition

Cited by 151 publications

References 0 publications

The use of complementary and alternative medications by menopausal women in South East Queensland

The use of complementary and alternative medications by menopausal women in South East Queensland

Serum antimüllerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: A longitudinal study

The ReSTAGE Collaboration: defining optimal bleeding criteria for onset of early menopausal transition

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