Three SARS-CoV-2 PCR-negative cases of COVID-19 diagnosed using isothermal amplification methods

Shinozawa, Saeko; Moriyama, Yuki

doi:10.1016/j.jiac.2022.04.002

Cited by 3 publications

(2 citation statements)

References 13 publications

(12 reference statements)

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“…PCR is still regarded as the gold standard test for diagnosing COVID-19. The sensitivity and specificity of PCR tests for detection of SARS-CoV-2 were 99% (95% CI, 97–99%) and 97% (95% CI, 95–98%), which are the most reliable test . A PCR test for one patient requires about 90 min .…”

Section: Resultsmentioning

confidence: 99%

“…The sensitivity and specificity of PCR tests for detection of SARS-CoV-2 were 99% (95% CI, 97−99%) and 97% (95% CI, 95−98%), which are the most reliable test. 50 A PCR test for one patient requires about 90 min. 51 Compared with the PCR test, our mini-portable sensor has lower sensitivity (0.917 (95% CI 0.760, 1.000)) and specificity (0.957 (95% CI 0.873, 1.000)).…”

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confidence: 99%

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Ultrasensitive NO Sensor Based on a Nickel Single-Atom Electrocatalyst for Preliminary Screening of COVID-19

Zhou

Tan

et al. 2022

ACS Sens.

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A new coronavirus, SARS-CoV-2, has caused the coronavirus disease-2019 (COVID-19) epidemic. A rapid and economical method for preliminary screening of COVID-19 may help to control the COVID-19 pandemic. Here, we report a nickel single-atom electrocatalyst that can be printed on a paper-printing sensor for preliminary screening of COVID-19 suspects by efficient detection of fractional exhaled nitric oxide (FeNO). The FeNO value is confirmed to be related to COVID-19 in our exploratory clinical study, and a machine learning model that can accurately classify healthy subjects and COVID-19 patients is established based on FeNO and other features. The nickel single-atom electrocatalyst consists of a single nickel atom with N2O2 coordination embedded in porous acetylene black (named Ni-N2O2/AB). A paper-printed sensor was fabricated with the material and showed ultrasensitive response to NO in the range of 0.3–180 ppb. This ultrasensitive sensor could be applied to preliminary screening of COVID-19 in everyday life.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%