Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding

Li, Hao; Vento, Peter J.; Parrilla-Carrero, Jeffrey; Pullmann, Dominika; Chao, Ying S.; Eid, Maya; Jhou, Thomas C.

doi:10.1016/j.neuron.2019.08.040

Cited by 53 publications

(56 citation statements)

References 71 publications

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“…70 Furthermore, a recent study has shown that there are three distinct afferents to the RMTg from prelimbic cortex, brainstem parabrachial nucleus, and LHb that drive triply dissociable RMTg responses to aversive cues, outcomes and prediction errors, respectively. 54 As for the downstream, data show that RMTg neurons broadcast punishment signals to multiple targets including the VTA and SNc. 53,54,71 Nature and Science of Sleep 2020:12 submit your manuscript | www.dovepress.com…”

Section: Dovepressmentioning

confidence: 94%

The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice

Zhao¹,

Yan²,

Wang³

et al. 2020

NSS

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The rostromedial tegmental nucleus (RMTg), a brake of the dopamine system, is specifically activated by aversive stimuli, such as foot shock. It is principally composed of gamma-aminobutyric acid neurons. However, there is no exact location of the RMTg on the brain stereotaxic atlas. The RMTg can be defined by c-Fos staining elicited by psychostimulants, the position of retrograde-labeled neurons stained by injections into the ventral tegmental area (VTA), the terminal field formed by axons from the lateral habenula, and some molecular markers identified as specifically expressed in the RMTg such as FoxP1. The RMTg receives a broad range of inputs and produces diverse outputs, which indicates that the RMTg has multiple functions. First, the RMTg plays an essential role for non-rapid eye movement sleep. Additionally, the RMTg serves a vital role in response to addiction. Opiates increase the firing rates of dopaminergic neurons in the VTA by acting on μ-opioid receptors on RMTg neurons and their terminals inside the VTA. In this review, we summarize the recent research advances on the anatomical location of the RMTg in rats and mice, its projections, and its regulation of sleep–wake behavior and addiction.

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Section: Dovepressmentioning

confidence: 94%

The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice

Zhao¹,

Yan²,

Wang³

et al. 2020

NSS

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“…RPE computations could also occur in the cortex-basal ganglia pathway itself, where subsets of neurons have RPErelated signals [52][53][54][55]. Indeed, these areas have all been implicated in predicting values, controlling the RPE system, or both [48,[55][56][57][58][59][60][61][62][63][64][65][66].…”

Section: How Do These Network Cooperate To Motivate Behavior?mentioning

confidence: 99%

Neural circuitry of information seeking

Bromberg-Martin

Monosov

2020

Current Opinion in Behavioral Sciences

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Humans and animals navigate uncertain environments by seeking information about the future. Remarkably, we often seek information even when it has no instrumental value for aiding our decisions-as if the information is a source of value in its own right. In recent years, there has been a flourishing of research into these non-instrumental information preferences and their implementation in the brain. Individuals value information about uncertain future rewards, and do so for multiple reasons, including valuing resolution of uncertainty and overweighting desirable information. The brain motivates this information seeking by tapping into some of the same circuitry as primary rewards like food and water. However, it also employs cortex and basal ganglia circuitry that predicts and values information as distinct from primary reward. Uncovering how these circuits cooperate will be fundamental to understanding information seeking and motivated behavior as a whole, in our increasingly complex and information-rich world.

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“…Much of the interest in the LHb has been driven by its modulation of rewardrelated phenomena and dopamine activity via the GABAergic neurons of the RMTg (Jhou et al, 2009a;Kaufling et al, 2009;Balcita-Pedicino et al, 2011;Stamatakis and Stuber, 2012;Laurent et al, 2017;Li et al, 2019a;Li et al, 2019b). However, only a minority of LHb neurons, predominantly in LHbL, appear to map to the RMTg (Goncalves et al, 2012;Quina et al, 2015).…”

Section: Components Of Gabaergic Transmission Expressed In the Lateramentioning

confidence: 99%

GAD2 Expression Defines a Class of Excitatory Lateral Habenula Neurons in Mice that Project to the Raphe and Pontine Tegmentum

Quina¹,

Walker²,

Morton³

et al. 2020

eNeuro

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Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding

Cited by 53 publications

References 71 publications

The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice

The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice

Neural circuitry of information seeking

GAD2 Expression Defines a Class of Excitatory Lateral Habenula Neurons in Mice that Project to the Raphe and Pontine Tegmentum

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