Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples

Desoubries, Charlotte; Chapuis-Hugon, Florence; Bossée, Anne; Pichon, Valérie

doi:10.1016/j.jchromb.2012.05.029

Cited by 21 publications

(19 citation statements)

References 42 publications

(63 reference statements)

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“…The solvent should be strongly maintained in the pores of the ûber, thus the polarity of organic solvent should be very close to the polarity of polypropylene ûber. In addition to, organic membrane solvent nature has to be adapted to the nature of the target analyte in order to favor their transfer [41]. therefore, 1-octanol, n-heptane, ncyclohexanol, and n-hexane were tested as organic membrane solvent.…”

Section: Choice Of the Organic Solventmentioning

confidence: 99%

Determination of Trace Amounts of Methamphetamine in Biological Samples by Hollow Fiber Liquid-phase Microextraction Followed by High Performance Liquid Chromatography

Darvish¹,

Qomi²,

Akhgari³

et al. 2015

Biosci., Biotechnol. Res. Asia

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Methamphetamineis used to treat Attention-deficit hyperactivity disorder (ADHD) or obesity as Desoxyn. In this work, for the first time a microextraction technique was introduced to detection and measurement of methamphetamine in urine and plasma samples. Hollow ûber based liquid phase microextraction (HF-LPME) followed by high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detection was used for extraction of methamphetamine. The organic solvent consists of 1-Octanol immobilized in the pores of a hollow fiber wall. A pH gradient was applied to migrate analytes from the sample solution with pH 11.6, through the organic solvent membraneinto an acidic acceptor solution with pH 2.8which was located inside the lumen of hollow fiber. Extraction recoveries upper than90% were obtainedin different biological matrices which resulted in preconcentration factors upper than 131.5 and acceptable repeatability (3.4< RSD%(n=6)<3.9). The method offers good linearity with estimation of coefficient higher than 0.9850. Finally, it was applied tothe detection and determination of methamphetamine in human plasma and urine samples.

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Section: Choice Of the Organic Solventmentioning

confidence: 99%

Determination of Trace Amounts of Methamphetamine in Biological Samples by Hollow Fiber Liquid-phase Microextraction Followed by High Performance Liquid Chromatography

Darvish¹,

Qomi²,

Akhgari³

et al. 2015

Biosci., Biotechnol. Res. Asia

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“…R is the recovery of the extraction given as a percentage. 33 As shown in Table 3, the enrichment factors (EFs) were between 59 and 260.…”

Section: -5mentioning

confidence: 99%

Determination of Non-Steroidal Anti-Inflammatory Drugs in Human Urine Sample using HPLC/UV and Three Phase Hollow Fiber-Liquid Phase Microextraction (HF-LPME)

Byoung¹,

Myung

2013

Bulletin of the Korean Chemical Society

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Three phase hollow fiber-liquid phase microextraction (HF-LPME), which is faster, simpler and uses a more environmentally friendly sample-preparation technique, was developed for the analysis of Non-Steroidal AntiInflammatory Drugs (NSAIDs) in human urine. For the effective simultaneous extraction/concentration of NSAIDs by three phase HF-LPME, parameters (such as extraction organic solvent, pH of donor/acceptor phase, stirring speed, salting-out effect, sample temperature, and extraction time) which influence the extraction efficiency were optimized. NSAIDs were extracted and concentrated from 4 mL of aqueous solution at pH 3 (donor phase) into dihexyl ether immobilized in the wall pores of a porous hollow fiber, and then extracted into the acceptor phase at pH 13 located in the lumen of the hollow fiber. After the extraction, 5 µL of the acceptor phase was directly injected into the HPLC/UV system. Simultaneous chromatographic separation of seven NSAIDs was achieved on an Eclipse XDB-C18 (4.6 mm i.d. × 150 mm length, 5 µm particle size) column using isocratic elution with 0.1% formic acid and methanol (30:70) at a HPLC-UV/Vis system. Under optimized conditions (extraction solvent, dihexyl ether; pH donor , 3; pH acceptor , 13; stirring speed, 1500 rpm; NaCl salt, 10%; sample temperature, 60 o C; and extraction time, 45 min), enrichment factors (EF) were between 59 and 260. The limit of detection (LOD) and limit of quantitation (LOQ) in the spiked urine matrix were in the concentration range of 5-15 ng/mL and 15-45 ng/mL, respectively. The relative recovery and precision obtained were between 58 and 136% and below 15.7% RSD, respectively. The calibration curve was linear within the range of 0.015-0.96 ng/mL with the square of the correlation coefficient being more than 0.997. The established method can be used to analyse of NSAIDs of low concentration (ng/mL) in urine.

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“…Moreover, the combination of LC with tandem mass spectrometry (MS/MS) offers the greatest level of specificity and sensitivity for their analysis [5]. Considering the LC separation, the HILIC mode [5,6], mixed-mode [7] and porous graphitic carbon systems [8] were used but reversed-phase liquid chromatography on C18 silica was the method of choice for their separation [9][10][11]. However, their presence at low concentration in a matrix with a high level of interfering compounds constitutes a real challenge.…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, experts of the Scientific Advisory Board of the organization for the prohibition of chemical warfare considered that HF-LPME is a very promising technique and can be recommended as an operational procedure for on-site and off-site analysis [20]. Two-phase HF-LPME was applied for the extraction of AMPAs in combination with different derivatization agents such as propyl bromide [8], N-tertbutyldimethylsilyl-N-methyltrifluoroacetamid (MTBSTFA) [9] or 3,5 trifluoromethyl benzene diazomethane [10]. Nevertheless, while removing the constraints linked to the derivation step, higher EFs were obtained with the three-phase HFLPME.…”

Section: Introductionmentioning

confidence: 99%

Parallel artificial liquid membrane extraction of organophosphorus nerve agent degradation products from environmental samples

Bouchouareb

Combès

Pichon

2022

Analytica Chimica Acta

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Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples

Cited by 21 publications

References 42 publications

Determination of Trace Amounts of Methamphetamine in Biological Samples by Hollow Fiber Liquid-phase Microextraction Followed by High Performance Liquid Chromatography

Determination of Trace Amounts of Methamphetamine in Biological Samples by Hollow Fiber Liquid-phase Microextraction Followed by High Performance Liquid Chromatography

Determination of Non-Steroidal Anti-Inflammatory Drugs in Human Urine Sample using HPLC/UV and Three Phase Hollow Fiber-Liquid Phase Microextraction (HF-LPME)

Parallel artificial liquid membrane extraction of organophosphorus nerve agent degradation products from environmental samples

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