Three peptides from the ANF prohormone NH<sub>2</sub>- terminus are natriuretic and/or kaliuretic

Martín, Daniel Ruiz; Pevahouse, Joe B.; Trigg, David; Vesely, David L.; Buerkert, John

doi:10.1152/ajprenal.1990.259.4.f731-r

Cited by 14 publications

(36 citation statements)

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“…1). Within the 126 a.a. prohormone in the heart are four peptide hormones whose main biologic properties are blood pressure regulation and maintenance of plasma volume in animals [5][6][7][8][9][10][11] and humans [12][13][14][15][16]. These peptide hormones, numbered by their a.a. sequences beginning at the N-terminal end of the ANP prohormone, consist of the first 30 a.a. of the prohormone-that is, long acting natriuretic peptide (LANP), vessel dilator (a.a. 31-67), kaliuretic peptide (a.a. 79-98), and ANP (a.a. 99-126) [2,3].…”

Section: Cardiac Natriuretic Peptidesmentioning

confidence: 99%

“…Vessel dilator, however, enhanced sodium and FE Na more than kaliuretic peptide and more than ANP, nesiritide, ularitide, and LANP in persons with chronic CHF. Vessel dilator, LANP, and kaliuretic peptide-as opposed to ANP, ularitide, and nesiritide-have never caused a hypotensive episode when given to either healthy animals [6][7][8][9][10][11] or humans [12,13] or when given to humans with sodium and water retention [14][15][16].…”

Section: Kaliuretic Peptidementioning

confidence: 99%

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Urodilatin: A better natriuretic peptide?

Vesely

2007

Curr Heart Fail Rep

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The kidney natriuretic peptide urodilatin (ie, ularitide) decreases pulmonary capillary wedge pressure (PCWP) but does not cause diuresis in persons with congestive heart failure (CHF). Thirty-three percent of patients with CHF treated with 30 ng/kg/min ularitide develop hypotension with systolic blood pressures below 90 mmHg. Nesiritide and atrial natriuretic peptide lower PCWP and cause hypotension. They do not produce diuresis or natriuresis in patients with CHF. The best natriuretic peptide for treating CHF is the cardiac hormone vessel dilator which decreases PCWP and decreases systemic and pulmonary vascular resistance while simultaneously increasing cardiac output and cardiac index. What makes the vessel dilator markedly better than atrial natriuretic peptide, nesiritide, and ularitide for treatment of CHF is that it enhances sodium excretion fivefold and causes a fivefold enhanced diuresis in patients with CHF with its biologic effects lasting over 6 hours compared with less than 30 minutes for the above peptides.

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Section: Cardiac Natriuretic Peptidesmentioning

confidence: 99%

Section: Kaliuretic Peptidementioning

confidence: 99%

Urodilatin: A better natriuretic peptide?

Vesely

2007

Curr Heart Fail Rep

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“…Natriuretic peptides (NPs) or natriuretic factors (NFs) belong to a large hormonal protein family (Martin et al 1990, Vesely et al 1993 that was identified in vertebrate (Gering et al 1996, Takei 2001, various invertebrate species (Takei 2001), in Paramecium sp. (Takei 2001) and plants (Vesely and Giordano 1991, Billington et al 1997, Yang et al 1999c, Gering 1999, Vesley et aL 2001.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Plant signalling peptides

2003

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A b s t r a c tBiochemical and genetic studies have identified peptides that play crucial roles in plant growth and development, including defence mechanisms in response to wounding by pests, the control of cell division and expansion, and pollen self-incompatibility. The first two signalling peptides to be described in plants were tomato systemin and phytosulfokine (PSK). There is also biochemical evidence that natriuretic peptide-like molecules, immunologically-related to those found in animals, may exist in plants. Another example of signalling peptide is ENOD40, a product of a gene, which became active early in the root nodulation process following Rhizobium infection of legumes. Other predicted bioactive peptides or oligopeptides have been identified by means of genetic, rather then biochemical methods. The Arabidopsis CLAVATA3 protein is required for the correct organization of the shoot apical meristem and the pollen S determinant S-locus cysteine-rich protein (SCR also called S-locus protein 11, SP11).The plant signalling peptides discovered so far are involved in various processes and play an important role in communication between cells or organs, respectively. This review will focus on these peptides and their role in intercellular signalling.

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“…Pro ANF 1-30, pro ANF 31-67, pro ANF 79-98 and ANF each have blood pressure lowering and diuretic properties in humans (Vesely et al 1994a,b) and animals (Martin et al 1990). In addition, pro ANF 1-30, pro ANF 3 1-67 and ANF, but not pro ANF 79-98, enhance sodium excretion in both humans (Vesely et al 1994a,b) and animals (Martin et al 1990).…”

Section: Biological Activity Of Atrial N At Ri U Re Ti C Peptid E Smentioning

confidence: 99%

ATRIAL NATRIURETIC HORMONES ORIGINATING FROM THE N‐TERMINUS OF THE ATRIAL NATRIURETIC FACTOR PROHORMONE

Vesely

1995

Clin Exp Pharma Physio

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1. Four peptide hormones consisting of amino acids 1-30 (Long Acting Sodium Stimulator), 31-67 (Vessel Dilator), 79-98 (Kaliuretic Stimulator) and 99-126 (atrial Natriuretic Factor [ANF]) originate from the same 126 amino acid ANF prohormone. 2. Each of these four peptide hormones circulates as a distinct peptide with vessel dilator and long acting sodium stimulator circulating at 10- to 24-fold higher concentrations than ANF while kaliuretic stimulator circulates at a three-fold higher concentration than ANF. 3. Each of these peptide hormones is released with an increase in central volume causing stretch of the atrium of the heart and with rapid heart beats greater than 125 beats/min. 4. Each of these peptide hormones lowers blood pressure, causes a diuresis and enhances sodium and/or potassium excretion. 5. In disease states which retain sodium and water such as congestive heart failure (CHF), each of these atrial peptides increases in the circulation proportionately to the severity of sodium retention, but of the radioimmunoassays to each of these hormones only the vessel dilator radioimmunoassay differentiates between mild (class I) CHF and healthy individuals.

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Three peptides from the ANF prohormone NH₂- terminus are natriuretic and/or kaliuretic

Cited by 14 publications

References 0 publications

Urodilatin: A better natriuretic peptide?

Urodilatin: A better natriuretic peptide?

Plant signalling peptides

ATRIAL NATRIURETIC HORMONES ORIGINATING FROM THE N‐TERMINUS OF THE ATRIAL NATRIURETIC FACTOR PROHORMONE

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Three peptides from the ANF prohormone NH2- terminus are natriuretic and/or kaliuretic

Cited by 14 publications

References 0 publications

Urodilatin: A better natriuretic peptide?

Urodilatin: A better natriuretic peptide?

Plant signalling peptides

ATRIAL NATRIURETIC HORMONES ORIGINATING FROM THE N‐TERMINUS OF THE ATRIAL NATRIURETIC FACTOR PROHORMONE

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Three peptides from the ANF prohormone NH₂- terminus are natriuretic and/or kaliuretic