Three peptides from the ANF prohormone NH₂- terminus are natriuretic and/or kaliuretic

Abstract

Pages 1401-1408: Daniel R. Martin, Joe B. Pevahouse, David J. Trigg, David L. Vesely, and John E. Buerkert. “Three peptides from the ANF prohormone NH2- terminus are natriuretic and/or kaliuretic.” Pages 1404 and 1406, Tables 2 and 3, respectively: in the boxhead, the units for UNaV should be μeq·min-1·g kidney wt-1.

Atrial natriuretic peptide(31-67) inhibits Na+ transport in rabbit inner medullary collecting duct cells. Role of prostaglandin E2.

“…Finally, infusion ofsynthetic ANP(31 67) into rats proves it to be natriuretic and diuretic, similar in potency to ANP(w126) (11 (12)(13)(14)(15). Inhibition of these Na+ channels is believed to cause reduced Na+ reabsorption, leading to natriuresis (3,12,15).…”

Neuroendocrine control of body fluid homeostasis

“…Consequently, we concluded that OT and ANP can account for the decrease in potassium excretion when there is a reduction in ANP release. This view may need modification with the recent discovery of a kaliuretic peptide, which produces kaliuresis with little or no natriuresis, and is the 20-amino acid peptide amino terminal extension of ANP (52).…”

Increased Release of Kaliuretic Peptide during Immersion-Induced Central Hypervolemia in Cirrhotic Humans

“…and renal hemodynamic effects, thus suggesting a role for ANF in the pathogenesis of sodium-retaining states [6][7][8], Previous studies from our laboratory have demonstrated that diminished renal responsiveness to ANF contributes in part to the sodium retention that accompanies cirrhosis [9], The peak urinary sodium excretion (Un3V) in cirrhot ic subjects varies independently of both basal ANF and degree of ANF augmentation induced by head-out water immersion, however, suggesting that other factors in addi tion to ANF are involved in the sodium retention ob served in cirrhosis [9], Kaliuretic peptide is a newly characterized peptide hormone consisting of amino acids 79-98 of the ANF prohormone ( fig. 1) [10][11][12]. This peptide has the stron-gest potassium-excreting properties in animals [11] and humans [12.…”

“…1) [10][11][12]. This peptide has the stron-gest potassium-excreting properties in animals [11] and humans [12. 13] of all the atrial natriuretic peptides.…”