Three Outbreak-causing<i>Neisseria meningitidis Serogroup</i>C Clones, Brazil1

Barroso, David E.; Castiñeiras, Terezinha Marta Pereira Pinto; Freitas, Fernanda; Marsh, Jane W.; Krauland, Mary G.; Tulenko, Mary M.; Fonseca, Érica L.; Vicente, Ana Carolina Paulo; Rebelo, Maria Cristina; Cerqueira, Elaine O.; Xavier, Adriano C.; Cardozo, Ana P.C.M.; Silva, Simone E.M. da; Harrison, Lee H.

doi:10.3201/eid1911.130610

Cited by 10 publications

(6 citation statements)

References 10 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MenC cc 103 has caused epidemics in two refineries in São Paulo, located in the southeast of the country, and was also described as the cause of an outbreak in the northeast of the country ( 10 , 17 ). Strain N79/96 cc 8 is a prototype strain of Rio de Janeiro’s outbreak occurred in the 1990’s ( 18 ). Of note, since 2002, serogroup C prevalence has overtaken serogroup B cases in most regions of Brazil.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of bactericidal antibodies against serogroup B and C Meningococci in a University Hospital

Gioia

Lemos

Gorla

et al. 2017

Braz J Med Biol Res

View full text Add to dashboard Cite

Meningococcus serogroup B (MenB), clonal complex 32 (cc 32), was the Brazilian epidemic strain of meningococcal disease (MD) in the 1990’s. Currently, meningococcus serogroup C (MenC), cc 103, is responsible for most of the cases of the disease in Brazil. The aim of this study was to investigate the seroprevalence of bactericidal antibody (SBA) against representative epidemic strains of MenC, (N753/00 strain, C:23:P1.22,14-6, cc103) and MenB, (Cu385/83 strain, B:4,7:P1.15,19, cc32) in students and employees of a university hospital in the State of Rio Grande do Sul (RS, Brazil). A second MenC strain (N79/96, C:2b:P1.5-2,10, cc 8) was used as a prototype strain of Rio de Janeiro’s outbreak that occurred in the 1990’s. Our previous study showed a 9% rate of asymptomatic carriers in these same individuals. A second goal was to compare the SBA prevalence in meningococcal carriers and non-carriers. Fifty-nine percent of the studied population showed protective levels of SBA titers (log2≥2) against at least one of the three strains. About 40% of the individuals had protective levels of SBA against N753/00 and Cu385/83 strains. Nonetheless, only 22% of the individuals showed protective levels against N79/96 strain. Significantly higher antibody levels were seen in carriers compared to non-carriers (P≤0.009). This study showed that, similar to other States in Brazil, a MenC (23:P1.22,14-6, cc103) strain with epidemic potential is circulating in this hospital. Close control by the Epidemiological Surveillance Agency of RS of the number of cases of MD caused by MenC strains in the State is recommended to prevent a new disease outbreak.

show abstract

Section: Discussionmentioning

confidence: 99%

Seroprevalence of bactericidal antibodies against serogroup B and C Meningococci in a University Hospital

Gioia

Lemos

Gorla

et al. 2017

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Tauil et al [110] evaluated the effect of MCC vaccine introduction on the specific age group reporting that, although children <2 years of age showed an elevated risk to die for MD, these rates were lower than those reported by other investigations [82]. Currently, these serogroup C clones, and especially cc103, constitute the main cause of endemic meningococcal disease in Brazil [109]. As for Chile, during 2010-2011, Barra et al [84] did not observe changes in serogroup C incidence, reporting an average of 11.5%.…”

Section: Serogroup C Meningococcal Disease Epidemiologymentioning

confidence: 91%

“…In Brazil, the last epidemic caused by serogroup C was reported in 1994 [109]. After a vaccination campaign with serogroup C polysaccharide, a reduction in serogroup C disease cases was observed, but they increased again in 2000.…”

Section: Serogroup C Meningococcal Disease Epidemiologymentioning

confidence: 98%

“…In particular, during the period 2003-2012, three hyperinvasive clonal complexes cc11, cc32 and cc103 were identified and associated with endemic disease, outbreaks and high CFR. Potentially, all the MM cases could be prevented through serogroup C meningococcal vaccine [109]. In order to control these outbreaks in 2010 MCC and meningococcal A/C polysaccharide vaccines were introduced in routine vaccinations restricted to children <2 years old [82,109] and recommended for people ‡ 2 years of age [82], respectively.…”

Section: Serogroup C Meningococcal Disease Epidemiologymentioning

confidence: 99%

“…Potentially, all the MM cases could be prevented through serogroup C meningococcal vaccine [109]. In order to control these outbreaks in 2010 MCC and meningococcal A/C polysaccharide vaccines were introduced in routine vaccinations restricted to children <2 years old [82,109] and recommended for people ‡ 2 years of age [82], respectively. Any mass vaccination program involved adolescents [110].…”

Section: Serogroup C Meningococcal Disease Epidemiologymentioning

confidence: 99%

See 2 more Smart Citations

Neisseria meningitidisinfection: who, when and where?

Gianchecchi

Torelli

Piccini

et al. 2015

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

Neisseria meningitidis is a Gram-negative β-proteobacterium responsible for an endemic worldwide infection. The epidemiology and serogroup distribution can change very quickly. The incidence of meningitis infection varies from very rare to more than 1000 cases per 100,000 of the population yearly. The carriage of N. meningitidis, which represents an exclusive human commensal, is asymptomatic, but in rare cases bacteria proliferate in the CNS and rapidly lead to the death of the affected subjects. Host genetic factors, such as single nucleotide polymorphisms, can promote meningococcal disease, being able to influence the individual predisposition to the pathology. Although a reduction in meningococcal disease has been observed in Europe, a continuous surveillance is necessary to control any possible outbreaks of new hypervirulent clones into populations that could modify the epidemiology of meningococcal infections and the clinical spectrum of affected subjects.

show abstract