Three order increase in scanning speed of space charge-controlled KTN deflector by eliminating electric field induced phase transition in nanodisordered KTN

Zhu, Wei; Chao, Ju Hung; Chen, Chang Jiang; Yin, Shizhuo; Hoffman, Robert C.

doi:10.1038/srep33143

Cited by 35 publications

(7 citation statements)

References 25 publications

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“…The sheer quantity of overlapping reading frames required in our laser based reading and writing of the DNA, necessitates the increase of scanning speeds to above the speed of movement of most molecules to a sufficient degree that their relative positions can be tracked. Studies into the 'overclocking' of crystals for laser scanning speed improvements of the order of 1000x will help this (Zhu et al 2016).…”

Section: Notes For Optimisationmentioning

confidence: 99%

Genetic and Molecular Scanning, Manipulation and Modification Device

Kitsune¹,

Alastor²,

Kelly³

et al. 2023

Laberation

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This invention relates to a combination of technologies being assembled in a manner enabling the scanning, manipulation, and modification of biological materials such as but not necessarily limited to Deoxyribonucleic Acid (hereafter referred to as 'DNA'), lipids, carbohydrates and proteins, and receipt or output of data (in formats that can be interpreted by computer systems and software) that pertain to these purposes.The device (here dubbed 'Geneticiser' or 'the device') is designed to be able to fulfill several use cases and solve these problems with minimal to no modification or alteration of it. The device is intended to utilize artificial intelligence, machine learning and/or similar technologies and methods to prevent issues, increase efficiency, and significantly save time.This document is set out in the format of a 'Defensive Publication' styled for both 'Open Patent' use (the earlier part of the document) and 'Whitepaper' or 'Detailed Paper' use (the later part mainly). It is an improved and expanded successor to the first defensive publication of the Original concept of the device, which was published via PubPub.org and made also available via a backup on the Vulpine Designs cloud server. Due to a series of unfortunate events, the original defensive publication is no longer available online at the time of writing. However, efforts are underway to restore the original defensive publication at PubPub.org (D. S. Davies 2017). The concept is based on an idea originally presented in the science fiction book, An Atom of Freedom (D. Davies 2012) which was originally published online at DeviantArt in 6-chapter intervals (D. S. Davies 2008). Background Problem 1: Genetic Disorders and CancerAt present, there are many cancer types and genetic disorders for which the pursuit of solutions and methods of treatment involve long and complex scientific investigations,

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Section: Notes For Optimisationmentioning

confidence: 99%

Genetic and Molecular Scanning, Manipulation and Modification Device

Kitsune¹,

Alastor²,

Kelly³

et al. 2023

Laberation

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“…After the first successful experiment and mechanism exploration of optical deflection in KTN crystal based on the quadratic electro-optical effect, kinds of optical beam splitter, optical switch, multi-dimensional scanning and ns magnitudes response have been designed and implemented. [12][13][14][15] According to the previous analysis of phase matching issues, the deflected angle of pump beam transits KTN crystal, which is put on voltage in the proposed scanning OPCPA, is given as below: [16] ∆θ m = θ m − θ m0 = − 9Ln 3 0 s i j 8d…”

Section: Theoretical Basis Of Phase-matched Scanning Opcpamentioning

confidence: 99%

Phase matched scanning optical parametric chirped pulse amplification based on pump beam deflection*

Ye¹,

Dong²,

Wu³

et al. 2021

Chinese Phys. B

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Combined with the optical beam deflection, a novel approach of phase matched broadband scanning optical parametric chirped pulse amplification (OPCPA) was proposed. For this scheme, there was no superfluous operations to the chirped signal pulse which propagated in a changeless direction straightforward, but the pump beam were deflected in space with time by passing through a KTN crystal, which was applied with varied driving voltage. The theories of phase matching of each chirped signal frequency based on pump beam deflection was analyzed detailedly. And the type-I amplification of chirped signal with 800 nm central wavelength and 20 nm bandwidth pumped by 532 nm in BBO crystal was simulated as a case in point. The simulation results showed that the spectral distribution of chirped signal pulse was almost the same as the initial form, i.e., there was nearly no narrowing on the amplified spectrum by using of the scanning OPCPA based on pump beam deflection. In addition, the simulations demonstrated that it was worth minimizing the voltage deviation applied to KTN crystal as much as possible for the sake of better waveform, larger bandwidth and higher conversion efficiency of amplified signal pulse in the proposed scanning OPCPA.

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“… 23 – 25 Although there is debate about the physical mechanisms involved, KTN devices have been shown to have nanosecond response times, limited primarily by the speed of drive electronics. 26 , 27 …”

Section: Introductionmentioning

confidence: 99%

Two-dimensional electro-optical multiphoton microscopy

Farinella,

Stanek,

Jayakumar

et al. 2024

Neurophoton.

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The development of genetically encoded fluorescent indicators of neural activity with millisecond dynamics has generated demand for ever faster two-photon (2P) imaging systems, but acoustic and mechanical beam scanning technologies are approaching fundamental limits. We demonstrate that potassium tantalate niobate (KTN) electro-optical deflectors (EODs), which are not subject to the same fundamental limits, are capable of ultrafast two-dimensional (2D) 2P imaging in vivo.Aim: To determine if KTN-EODs are suitable for 2P imaging, compatible with 2D scanning, and capable of ultrafast in vivo imaging of genetically encoded indicators with millisecond dynamics.Approach: The performance of a commercially available KTN-EOD was characterized across a range of drive frequencies and laser parameters relevant to in vivo 2P microscopy. A second KTN-EOD was incorporated into a dual-axis scan module, and the system was validated by imaging signals in vivo from ASAP3, a genetically encoded voltage indicator.Results: Optimal KTN-EOD deflection of laser light with a central wavelength of 960 nm was obtained up to the highest average powers and pulse intensities tested (power: 350 mW; pulse duration: 118 fs). Up to 32 resolvable spots per line at a 560 kHz line scan rate could be obtained with single-axis deflection. The complete dual-axis EO 2P microscope was capable of imaging a 13 μm by 13 μm field-of-view at over 10 kHz frame rate with ∼0.5 μm lateral resolution. We demonstrate in vivo imaging of neurons expressing ASAP3 with high temporal resolution. Conclusions:We demonstrate the suitability of KTN-EODs for ultrafast 2P cellular imaging in vivo, providing a foundation for future high-performance microscopes to incorporate emerging advances in KTN-based scanning technology.

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Three order increase in scanning speed of space charge-controlled KTN deflector by eliminating electric field induced phase transition in nanodisordered KTN

Cited by 35 publications

References 25 publications

Genetic and Molecular Scanning, Manipulation and Modification Device

Genetic and Molecular Scanning, Manipulation and Modification Device

Phase matched scanning optical parametric chirped pulse amplification based on pump beam deflection*

Two-dimensional electro-optical multiphoton microscopy

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