Three nona-2,7-dienoic acid derivatives from saltern derived Micromonospora sp. FXY415

Abstract

Three new compounds, apocimycin A-C, were identified from a salternderived Micromonospora sp. strain FXY415, isolated from Dongshi saltern, Fujian, China. Their planar structures and relative configuration were confirmed mainly by analysis of 1D-and 2D-NMR spectra. Three compounds belong to 4, 6, 8 -trimythyl nona-2, 7-dienoic acid derivatives, apocimycin A also has a phenoxazine nucleus. Apocimycin A-C exhibited weak cytotoxic and antimicrobial activities. Our research showed again that microbial communities in extreme environments are potential resource in looking for new and bioactive led compounds.