Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity

Abstract

Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.

Swertia L.: A comprehensive review of its genetic relationship, chemical compositions, pharmacological effects, toxicities, and applications

“…Xanthones are commonly found in several medicinal plants of Swertia L. They are present in relatively high concentrations and have a complex composition and specific structures (Wu, Li, et al, 2017; Wu, Sheng, et al, 2017). And 16 Xanthones have been isolated from S. chirayita , S. mussotii , and S. speciosa , especially S. mussotii (He et al, 2017).…”

“…Is abundant and widespread in Asia, North America, and Africa (Xu et al, 2017). As a commonly used ethnic medicine, Swertia L. is widely distributed in Sichuan, Yunnan, and Xizang in China (Li, Zhao, et al, 2017; Wu, Li, et al, 2017; Wu, Sheng, et al, 2017). Meanwhile, Swertia L. belongs to one of the critical sources of medicinal plants, and the herbs of this genus have been recorded in the classical books of Yue Wang Yao Zhen, Si Bu Yi Dian, Lan Liu Li, and Jing Zhu Ben Cao owing to their prominent efficacy (Liu et al, 2015; Liu et al, 2011).…”