Three New Trisaccharides Obtained from Human Blood-Group A, B, H and Lea Substances: Possible Sugar Sequences in the Carbohydrate Chains

Rege, Vaijayanti P.; Painter, Terence; Watkins, Winifred M.; Morgan, W. T. J.

doi:10.1038/200532a0

Cited by 103 publications

(24 citation statements)

References 28 publications

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“…It is proposed that the son's genotype is A2BjAx and his phenotype, consequently, A2B. Although this discussion has assumed that A and B substances are under the control of genes at a single locus, biochemical evidence indicates that, whereas A substance contains the disaccharide Nacetylgalactosaminoyl-galactose, B substance contains galactosylgalactose [14], and it could be argued that, since two different bio chemical syntheses are involved, two enzymes of different specificities and, consequently, two gene loci, are concerned, as suggested, on other grounds, by Bodmer and Parsons [4]. However, if two separate gene loci are involved, it would be expected that recombina tion between the A and B genes would produce both AXB and A2B configurations and that, providing there were no selective differences, these would exist in the ratio of the A1 and A2 gene frequencies.…”

mentioning

confidence: 99%

Modification of Bernstein’s Multiple Allele Theory for the Inheritance of the ABO Blood Groups in the Light of Modern Genetical Concepts

Boettcher¹

1966

Vox Sanguinis

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mentioning

confidence: 99%

Modification of Bernstein’s Multiple Allele Theory for the Inheritance of the ABO Blood Groups in the Light of Modern Genetical Concepts

Boettcher¹

1966

Vox Sanguinis

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“…Blood group substances are formed by the sequential addition of specific monosaccharides to carbohydrates of glycoproteins and glycolipids. The structures are based on two backbone sequences: Type 1 (containing GaI-~-I-3-GlcNAc units), and Type 2 (containing Gal-~-I-4-GlcNAc units) to which L-fucose and, in some cases, GalNAc or D-Gal are added to produce various blood group specificities (Rege et al, 1963). Antigen O(H) is formed by the addition of Fuc to the terminal Gal of a glycolipid or glycoprotein backbone structure by the action of H Fuc transferase.…”

Section: Discussionmentioning

confidence: 99%

Studies of lectin binding to the human cervix uteri: I. Normal cervix

1989

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Lectins of Bauhinia purpurea (BPA), Canavalin ensiformis (Con A), Griffonia simplicifolia I (GS I), Griffonia simplicifolia II (GS II), Maclura pomifera (MPA), Arachis hypogaea (PNA), Glycine max (SBA), Ulex europaeus I (UEA I) and Triticum vulgaris (WGA) were used to evaluate cell surface carbohydrates in formalin-fixed paraffin-embedded tissue sections of normal human cervix uteri. Consistent patterns of staining of the squamous epithelium were obtained in all 30 cases with BPA, GS II, MPA, PNA, SBA and WGA. A variable distribution of lectin binding was seen in squamous epithelium with Con A, GS I and UEA I. The patterns of GS I and GS II binding reflected squamous epithelial maturation. Columnar epithelium did not stain with GS II, stained variably with Con A, and stained consistently with the remaining seven lectins in all cases. No association between lectin binding and blood group or phase of the menstrual cycle was found. These findings may be used as a baseline for evaluation of lectin binding in both preinvasive and invasive lesions of the cervix uteri.

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“…[2] The ABO histo-blood group system can be further subtyped according to the carbohydrate residue present at the reducing end, into what is now referred to as type I through to type VI (Table 1). [4,11,12] To date, limited studies have been done to determine the biological importance of these structural subtypes. However, those studies that have been carried out suggest, not surprisingly, that these structural differences * Dedicated to Professor Robert V. Stick on the occasion of his retirement.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of ABO Histo-Blood Group Type V and VI Antigens

Meloncelli

Lowary

2009

Aust. J. Chem.

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The ABO histo-blood group antigens have long been of interest to chemists, biochemists, and evolutionary biologists. However, to date, a complete synthesis of all ABO histo-blood group antigens has not been conducted, despite the potential for such a panel to provide a more detailed understanding of the biological roles of these glycan motifs. Here we report the chemical synthesis of the A, B, and H type V and VI antigens in multi-milligramme quantities as part of an overall goal to prepare all 18 A, B, and H antigens. The A and B type V and VI antigens were prepared with a 7-octen-1-yl linker, to enable future conjugation to a protein or solid support. The H type V and VI antigens were prepared as the octyl glycoside, to facilitate detailed enzyme kinetics studies.

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Three New Trisaccharides Obtained from Human Blood-Group A, B, H and Lea Substances: Possible Sugar Sequences in the Carbohydrate Chains

Cited by 103 publications

References 28 publications

Modification of Bernstein’s Multiple Allele Theory for the Inheritance of the ABO Blood Groups in the Light of Modern Genetical Concepts

Modification of Bernstein’s Multiple Allele Theory for the Inheritance of the ABO Blood Groups in the Light of Modern Genetical Concepts

Studies of lectin binding to the human cervix uteri: I. Normal cervix

Synthesis of ABO Histo-Blood Group Type V and VI Antigens

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