Three new steroidal saponins from the roots and rhizomes of Rohdea chinensis (Baker) N.Tanaka (synonym Tupistra chinensis Baker)

Abstract

Three new steroidal saponins from the roots and rhizomes of Rohdea chinensis (Baker) N.Tanaka (synonym Tupistra chinensis Baker)

Furostanol Saponins from Asparagus cochinchinensis and Their Cytotoxicity

“…The steroid saponins obtained from species of Liliaceae have shown the potential to significantly inhibit the proliferations of various human tumor cell lines in vitro [25][26][27][28][29]. Therefore, all isolated compounds were evaluated for their cytotoxicity against MHCC97H and H1299 by the MTT method.…”

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

“…T. chinensis, T. wattii, and T. yunnanensis are main sources of spirostanol and furostanol saponins. Sixty-five compounds were assigned as spirostanol saponins (Table 1 and Figure 2), 2,[7][8][9][10]21,22,24,28,[31][32][33]35,36,39 while compounds 85 to 150 are furostanol saponins (Table 1 and Figure 3). 5,8,10,18,22,24,31,35,37,[39][40][41][42][43][44][45][46][47] Taking spirostanol saponins into consideration, glycosylation generally happens at C-1, C-3, C-5, and C-24.…”

“…Based on physicochemical results and NMR spectral analysis, Song et al reported that the 65% EtOH extract of T. chinensis underground parts contained 2 new spirostanol saponins, (24S,25R)-1β-hydroxy-3β-[(β-Dglucopyranoside)oxy]-spirost-5-en-24-yl-β-D-glucopyranoside (34), and (24S)-spirost-25 (27)-en-1β,3β,4β,5β,6β,24β-hexahydroxy-24-O-β-D-glucopyranoside (59), in addition to 2 known ones, 3-epi-diosgenin-3-β-D-glucopyranoside (32), and 25(R)-1β-hydroxy-spirost-5-en-3α-yl-O-β-D-glucopyranoside [3-epi-ruscogenin-3-β-D-glucopyranoside] (35). 8 In 2016, Xiang et al reported that the 60% EtOH extract of T. chinensis rhizome was characterized by the presence of 18 new compounds, (25R)-5β-spirostan-1β,3β-diol-3-O-β-D-fructofuranosyl-(2→6)-β-D-glucopyranoside (46), (25R)-5β-spirostan-1β, 3α-diol-3-O-β-D-glucopyranoside (47) 9,10,22,39 Thus, the root and rhizome of T. chinensis may be thought of as a rich resource of new spirostanol saponins. In another phytochemical report, apart from the known compound rhodeasapogenin 1-(β-D-xylopyranoside) (44), the 95% EtOH extract of Chinese T. chinensis rhizome also contained one new steroidal saponin, tupichinin A (72).…”

“…4 Studies on Tupistra plants have shown therapeutically critical evidence, such as cytotoxic, anti-inflammatory, antimicrobial, and antidiabetic activities. [4][5][6][7][8][9][10] Regarding phytochemical reports, steroids, flavonoids, phenols, and aromatic derivatives can be considered as major secondary metabolites. [4][5][6][7][8][9][10] Although experimental reports are now abundant, none of the overviews has been discussed so far.…”

“…[4][5][6][7][8][9][10] Regarding phytochemical reports, steroids, flavonoids, phenols, and aromatic derivatives can be considered as major secondary metabolites. [4][5][6][7][8][9][10] Although experimental reports are now abundant, none of the overviews has been discussed so far. The current review aims to provide useful information on the phytochemistry and pharmacology of the genus Tupistra.…”