Three New Limonoids from Cipadessa cinerascens.

Abstract

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Analysis of cipadesin limonoids from Cipadessa cinerascens using electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry and quantum chemical calculations

“…HPLC grade methanol was obtained from Fisher Scientific (Pittsburgh, PA, USA), deuterated methanol from Merck (Andover, MA, USA), ammonium acetate from Guoyao (Chengdu, SC, PRC) and mass calibrant ion standards from Agilent Technologies (Santa Clara, CA, USA). Cipadesins A–F were isolated from leaves and barks of Cipadessa cinerascens . All the samples were dissolved in MeOH for MS analysis.…”

“…Cipadesins A-F were isolated from leaves and barks of Cipadessa cinerascens. [2,3] All the samples were dissolved in MeOH for MS analysis. The deuterium-labeling experiments of cipadesin E (1), cipadesin F (3) and cipadesin B (4) were carried out by incubation of 0.1 mg samples in 2 mL CD 3 OD for 24 h, respectively.…”

“…In our laboratory, six limonoids possessing unique skeletons, that is cipadesins A–F (Fig. ), were isolated from cipadessa cinerascens . Some limonoids possessing similar structures to cipadesins D–F have shown biological activity .…”

“…Limonoids, a class of tetranortriterpenoids, are mainly found in plants belonging to the families Rutaceae and Meliaceae. [1][2][3][4][5][6][7] They exhibit various biological effects, such as insect antifeedant and growth regulating activities, [8] antimicrobial activity, [9] potent cell adhesion inhibitory effects, [10] antimalarial activity against Plasmodium falciparum, [11] anticancer activities, [12,13] and antioxidant activity. [14] The potential application brings the need for reliable, fast and low-cost analysis of this class of compounds.…”

“…1), were isolated from cipadessa cinerascens. [2,3] Some limonoids possessing similar structures to cipadesins D-F have shown biological activity. [4,11] The potential application prospect and unique skeleton prompted us to study the structural characterization of these compounds using MS. To our knowledge, these compounds have not been studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS).…”